22 research outputs found
Synthesis of 1-Substituted Indole-3-Carboxaldehyde related to Acyclic Nucleosides and their Condensed Pyrenyl Derivatives
Synthesis Of Novel Substituted Pyrazolines And Isoxazolines Containing Indole And Coumarines
Ofloxacin ocular inserts: Design, Formulation and Evaluation
In developing a drug delivery strategy, issues of absorption,
distribution, metabolism, and elimination must be considered. The eye
presents unique opportunities and challenges when it comes to the
delivery of pharmaceuticals. While absorption by this route is
bungling, there are few side effects with conventional ocular dosage
forms. Hence, ocular inserts were prepared with prolonged release of
drug and minimum swelling within cul-de-sac using ofloxacinas a model
drug; and hydroxy propyl methyl cellulose, methyl cellulose, poly vinyl
pyrrolidone and poly vinyl alcohol as polymers. PEG-400 was
incorporated as plasticizer. The main purpose of the study was to
deliver the drug in zero order kinetics. Solvent casting technique was
followed to prepare ofloxacin ocular films. Eight formulations were
formulated and subjected to various physicochemical evaluations. Ocular
inserts prepared were smooth and passed all the evaluation tests
performed. Formulation OF2 shows a maximum cumulative percentage drug
release of 91.27 % at the end of 24 hours. Ocuserts formulated also
passed the test for sterility. They showed zero-order release of the
drug in the in vitro and in vivo release studies. The drug in the films
was found to be active against selected microorganisms as was proved by
microbial efficacy studies. A high correlation coefficient was found
between in vitro and in vivo release rate studies. Shelf-life of the
product was found to be more than one year.The results of in vitro, in
vivo, kinetic treatment (zero order and Korsemeyer s regression
values) and rate constant k value suggest that OF2 was the
best formulation among the formulations studied for formulating
ofloxacin ocular insert