11 research outputs found

    Cultural Heritage Digital Libraries: Needs and Components

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    This paper describes preliminary conclusions from a long-term study of cultural heritage digital collections. First, those features most important to cultural heritage digital libraries are described. Second, we list those components that have proven most useful in boot-strapping new collections

    A Genomic Regulatory Network for Development

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    Original article can be found at: http://www.sciencemag.org/ Copyright American Association for the Advancement of Science. [Full text of this article is not available in the UHRA]Development of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.Peer reviewe

    The Developmental Origins of Animal Bodyplans

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