Automotive Stirling engine development program

The study of high power kinematic Stirling engines for transportation use, testing of Mod I and Mod II Stirling engines, and component development activities are summarized. Mod II development testing was performed to complete the development of the basic engine and begin characterization of performance. Mod I engines were used for Mod II component development and to obtain independent party (U.S. Air Force) evaluation of Stirling engine vehicle performance

Sofosbuvir and Daclatasvir Combination Therapy in a Liver Transplant Recipient With Severe Recurrent Cholestatic Hepatitis C

Recurrent HCV infection following liver transplantation can lead to accelerated allograft injury that is difficult to treat with interferon. The aim of this study is to describe the first ever use of an interferon‐free, all oral regimen in a liver transplant recipient with severe recurrent HCV. A 54‐year‐old male with HCV genotype 1b developed severe cholestatic HCV at 6 months posttransplant with ascites, AST 503 IU/mL, alkaline phosphatase of 298 IU/mL, HCV RNA of 12 000 000 IU/mL, and histological cholestasis with pericellular fibrosis. Sofosbuvir, an HCV polymerase inhibitor (400 mg/day), and daclatasvir, an HCV NS5A replication complex inhibitor (60 mg/day), were co‐administered for 24 weeks. Within 4 weeks of initiating treatment, serum HCV RNA levels became undetectable and liver biochemistries normalized with concomitant resolution of ascites. The patient achieved a sustained virological response with undetectable HCV RNA at 9 months posttreatment. During and following treatment, the daily dose and blood level of tacrolimus remained stable and unchanged. The rapid and sustained suppression of HCV replication in this liver transplant recipient provides great promise for the use of combination oral antiviral regimens in other immunosuppressed and interferon refractory HCV patients. A patient with severe cholestatic hepatitis C virus genotype 1b infection at nine months after liver transplantation was successfully treated with a six‐month course of oral sofosbuvir in combination with daclatasvir and remains HCV RNA negative during posttreatment follow‐up with improved liver biochemistries and health.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/98302/1/ajt12209.pd

Movements and habitat use of native and invasive piscivorous fishes in a temperate and channelized lowland river

Lowland temperate rivers provide important habitats for piscivorous fishes, but with their year-round spatial and temporal habitat use is often poorly understood, including their use of off-channel habitats. Here, the movements and habitat use of the piscivorous native Northern pike Esox lucius and invasive pikeperch Sander lucioperca were investigated using acoustic telemetry in the highly regulated (through impoundment) lower River Severn, Western England over a 12-month period, where off-channel habitat availability was limited to a single boat marina. The movements of both species varied with season and temperature, with both species moving greater distances in spring. Increasing water temperatures up to 15 °C resulted in a higher frequency of movements of both species, but movements then decreased at temperatures higher than this. Northern pike detections in the river increased in periods of lower river discharge and warmer temperatures, with the off-channel refuge providing an important habitat all year round (78% of detections occurred there). While 63% of pikeperch detections also occurred in the marina, 89% of these detections occurred between December and April. These results thus emphasise the importance of this limited off-channel habitat as potential spawning locations for invasive pikeperch and foraging areas for native Northern pike

Individual variability in the movement ecology of Northern pike Esox lucius in a highly connected wetland system

Maintaining hydrological connectivity is important for sustaining freshwater fish populations as the high habitat connectivity supports large-scale fish movements, enabling individuals to express their natural behaviours and spatial ecology. Northern pike Esox lucius is a freshwater apex predator that requires access to a wide range of functional habitats across its lifecycle, including spatially discrete foraging and spawning areas. Here, pike movement ecology was assessed using acoustic telemetry and stable isotope analysis in the River Bure wetland system, eastern England, comprising of the Bure mainstem, the River Ant and Thurne tributaries, plus laterally connected lentic habitats, and a system of dykes and ditches. Of 44 tagged pike, 30 were tracked for over 100 days, with the majority of detections being in the laterally connected lentic habitats and dykes and ditches, but with similar numbers of pike detected across all macrohabitats. The movement metrics of these pike indicated high individual variability, with total ranges to over 26 km, total movements to over 1182 km and mean daily movements to over 2.9 km. Pike in the Thurne tributary were more vagile than those in the Ant and Bure, and with larger Thurne pike also having relatively high proportions of large-bodied and highly vagile common bream Abramis brama in their diet, suggesting the pike movements were potentially related to bream movements. These results indicate the high individual variability in pike movements, which was facilitated here by their access to a wide range of connected macrohabitats due to high hydrological connectivity

Insights into toxic prymnesium parvum blooms:The role of sugars and algal viruses

Prymnesium parvum is a toxin-producing microalga that causes harmful algal blooms globally, which often result in large-scale fish kills that have severe ecological and economic implications. Although many toxins have previously been isolated from P. parvum, ambiguity still surrounds the responsible ichthyotoxins in P. parvum blooms and the biotic and abiotic factors that promote bloom toxicity. A major fish kill attributed to P. parvum occurred in Spring 2015 on the Norfolk Broads, a low-lying set of channels and lakes (Broads) found on the East of England. Here, we discuss how water samples taken during this bloom have led to diverse scientific advances ranging from toxin analysis to discovery of a new lytic virus of P. parvum, P. parvum DNA virus (PpDNAV-BW1). Taking recent literature into account, we propose key roles for sialic acids in this type of viral infection. Finally, we discuss recent practical detection and management strategies for controlling these devastating blooms

Process evaluation results from the HEALTHY physical education intervention

Process evaluation is an assessment of the implementation of an intervention. A process evaluation component was embedded in the HEALTHY study, a primary prevention trial for Type 2 diabetes implemented over 3 years in 21 middle schools across the United States. The HEALTHY physical education (PE) intervention aimed at maximizing student engagement in moderate-to-vigorous physical activity through delivery of structured lesson plans by PE teachers. Process evaluation data collected via class observations and interventionist interviews assessed fidelity, dose delivered, implementor participation, dose received and barriers. Process evaluation results indicate a high level of fidelity in implementing HEALTHY PE activities and offering 225 min of PE every 10 school days. Concerning dose delivered, students were active for approximately 33 min of class, representing an average of 61% of the class time. Results also indicate that PE teachers were generally engaged in implementing the HEALTHY PE curriculum. Data on dose received showed that students were highly engaged with the PE intervention; however, student misbehavior was the most common barrier observed during classes. Other barriers included teacher disengagement, large classes, limited gym space and poor classroom management. Findings suggest that the PE intervention was generally implemented and received as intended despite several barriers

Rationale, design and methods for process evaluation in the HEALTHY study

The HEALTHY study was a multi-site randomized trial designed to determine whether a 3-year school-based intervention targeting nutrition and physical activity behaviors could effectively reduce risk factors associated with type 2 diabetes in middle school children. Pilot and formative studies were conducted to inform the development of the intervention components and the process evaluation methods for the main trial. During the main trial, both qualitative and quantitative assessments monitored the fidelity of the intervention and motivated modifications to improve intervention delivery. Structured observations of physical education classes, total school food environments, classroom-based educational modules, and communications and promotional campaigns provided verification that the intervention was delivered as intended. Interviews and focus groups yielded a multidimensional assessment of how the intervention was delivered and received, as well as identifying the barriers to and facilitators of the intervention across and within participating schools. Interim summaries of process evaluation data were presented to the study group as a means of ensuring standardization and quality of the intervention across the seven participating centers. Process evaluation methods and procedures documented the fidelity with which the HEALTHY study was implemented across 21 intervention schools and identified ways in which the intervention delivery might be enhanced throughout the study

Streamlined Calibrations of the ATLAS Precision Muon Chambers for Initial LHC Running

The ATLAS Muon Spectrometer is designed to measure the momentum of muons with a resolution of dp/p = 3% and 10% at 100 GeV and 1 TeV momentum respectively. For this task, the spectrometer employs 355,000 Monitored Drift Tubes (MDTs) arrayed in 1200 Chambers. Calibration (RT) functions convert drift time measurements into tube-centered impact parameters for track segment reconstruction. RT functions depend on MDT environmental parameters and so must be appropriately calibrated for local chamber conditions. We report on the creation and application of a gas monitor system based calibration program for muon track reconstruction in the LHC startup phase.Comment: 25 pages, 21 figure

Social factors related to the clinical severity of influenza cases in Spain during the A(H1N1)2009 virus pandemic

Background During the 2009 influenza pandemic, a change in the type of patients most often affected by influenza was observed. The objective of this study was to assess the role of individual and social determinants in hospitalizations due to influenza A (H1N1) 2009 infection. Methods We studied hospitalized patients (cases) and outpatients (controls) with confirmed influenza A (H1N1) 2009 infection. A standardized questionnaire was used to collect data. Variables that might be related to the hospitalization of influenza cases were compared by estimation of the odds ratio (OR) and 95% confidence intervals (CI) and the variables entered into binomial logistic regression models. Results Hospitalization due to pandemic A (H1N1) 2009 influenza virus infections was associated with non-Caucasian ethnicity (OR: 2.18, 95% CI 1.17 − 4.08), overcrowding (OR: 2.84, 95% CI 1.20 − 6.72), comorbidity and the lack of previous preventive information (OR: 2.69, 95% CI: 1.50 − 4.83). Secondary or higher education was associated with a lower risk of hospitalization (OR 0.56, 95% CI: 0.36 − 0.87) Conclusions In addition to individual factors such as comorbidity, other factors such as educational level, ethnicity or overcrowding were associated with hospitalization due to A (H1N1) 2009 influenza virus infections

Acoustic telemetry reveals strong spatial preferences and mixing during successive spawning periods in a partially migratory common bream population

Partial migration, whereby a population comprises multiple behavioural phenotypes that each have varying tendencies to migrate, is common among many animals. Determining the mechanisms by which these phenotypes are maintained is important for understanding their roles in population structure and stability. The aim here was to test for the temporal and spatial consistency of migratory phenotypes in a common bream Abramis brama (‘bream’) population, and then determine their social preferences and extent of mixing across three successive annual spawning periods. The study applied passive acoustic telemetry to track the movements of bream in the River Bure system of the Norfolk Broads, a lowland wetland comprising highly connected riverine and lacustrine habitats. Analyses revealed that individual migratory phenotype was highly consistent across the three years, but this was not predicted by fish sex or length at tagging. During the annual spawning periods, network analyses identified off-channel areas visited by both resident and migrant fish that, in non-spawning periods, were relatively independent in their space use. Within these sites, the co-occurrence of bream was non-random, with individuals forming more preferred and avoided associations than expected by chance. These associations were not strongly predicted by similarity in fish length, sex or behavioural phenotype, indicating that the resident and migrant phenotypes mixed during their annual spawning periods. The results suggested these different phenotypes, with spatially distinct resource use in non-spawning periods, comprised a single metapopulation, with this having important implications for the management of this wetland resource