Introduction to The Chinese and the Iron Road

Excerpt from The Chinese and the Iron Road: Building the Transcontinental Railroad, edited by Gordon H. Chang and Shelley Fisher Fishkin, with Hilton Obenzinger and Roland Hs

Teenagers’ understandings of and attitudes towards vaccines and vaccine-preventable diseases: a qualitative study

<p>Background: To examine immunisation information needs of teenagers we explored understandings of vaccination and vaccine-preventable diseases, attitudes towards immunisation and experiences of immunisation. Diseases discussed included nine for which vaccines are currently offered in the UK (human papillomavirus, meningitis, tetanus, diphtheria, polio, whooping cough, measles, mumps and rubella), and two not currently included in the routine UK schedule (hepatitis B and chickenpox).</p> <p>Methods Twelve focus groups conducted between November 2010 and March 2011 with 59 teenagers (29 girls and 30 boys) living in various parts of Scotland.</p> <p>Results Teenagers exhibited limited knowledge and experience of the diseases, excluding chickenpox. Measles, mumps and rubella were perceived as severe forms of chickenpox-like illness, and rubella was not associated with foetal damage. Boys commonly believed that human papillomavirus only affects girls, and both genders exhibited confusion about its relationship with cancer. Participants considered two key factors when assessing the threat of diseases: their prevalence in the UK, and their potential to cause fatal or long-term harm. Meningitis was seen as a threat, but primarily to babies. Participants explained their limited knowledge as a result of mass immunisation making once-common diseases rare in the UK, and acknowledged immunisation's role in reducing disease prevalence.</p> <p>Conclusions While it is welcome that fewer teenagers have experienced vaccine-preventable diseases, this presents public health advocates with the challenge of communicating benefits of immunisation when advantages are less visible. The findings are timely in view of the Joint Committee on Vaccination and Immunisation's recommendation that a booster of meningitis C vaccine should be offered to teenagers; that teenagers did not perceive meningitis C as a significant threat should be a key concern of promotional information. While teenagers’ experiences of immunisation in school were not always positive, they seemed enthusiastic at the prospect of introducing more vaccines for their age group.</p&gt

Eta invariants as sliceness obstructions and their relation to Casson-Gordon invariants

We give a useful classification of the metabelian unitary representations of pi_1(M_K), where M_K is the result of zero-surgery along a knot K in S^3. We show that certain eta invariants associated to metabelian representations pi_1(M_K) --> U(k) vanish for slice knots and that even more eta invariants vanish for ribbon knots and doubly slice knots. We show that our vanishing results contain the Casson-Gordon sliceness obstruction. In many cases eta invariants can be easily computed for satellite knots. We use this to study the relation between the eta invariant sliceness obstruction, the eta-invariant ribbonness obstruction, and the L^2-eta invariant sliceness obstruction recently introduced by Cochran, Orr and Teichner. In particular we give an example of a knot which has zero eta invariant and zero metabelian L^2-eta invariant sliceness obstruction but which is not ribbon.Comment: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol4/agt-4-39.abs.htm

Proximal genomic localization of STAT1 binding and regulated transcriptional activity

BACKGROUND: Signal transducer and activator of transcription (STAT) proteins are key regulators of gene expression in response to the interferon (IFN) family of anti-viral and anti-microbial cytokines. We have examined the genomic relationship between STAT1 binding and regulated transcription using multiple tiling microarray and chromatin immunoprecipitation microarray (ChIP-chip) experiments from public repositories. RESULTS: In response to IFN-γ, STAT1 bound proximally to regions of the genome that exhibit regulated transcriptional activity. This finding was consistent between different tiling microarray platforms, and between different measures of transcriptional activity, including differential binding of RNA polymerase II, and differential mRNA transcription. Re-analysis of tiling microarray data from a recent study of IFN-γ-induced STAT1 ChIP-chip and mRNA expression revealed that STAT1 binding is tightly associated with localized mRNA transcription in response to IFN-γ. Close relationships were also apparent between STAT1 binding, STAT2 binding, and mRNA transcription in response to IFN-α. Furthermore, we found that sites of STAT1 binding within the Encyclopedia of DNA Elements (ENCODE) region are precisely correlated with sites of either enhanced or diminished binding by the RNA polymerase II complex. CONCLUSION: Together, our results indicate that STAT1 binds proximally to regions of the genome that exhibit regulated transcriptional activity. This finding establishes a generalized basis for the positioning of STAT1 binding sites within the genome, and supports a role for STAT1 in the direct recruitment of the RNA polymerase II complex to the promoters of IFN-γ-responsive genes

Noncommutative knot theory

The classical abelian invariants of a knot are the Alexander module, which is the first homology group of the the unique infinite cyclic covering space of S^3-K, considered as a module over the (commutative) Laurent polynomial ring, and the Blanchfield linking pairing defined on this module. From the perspective of the knot group, G, these invariants reflect the structure of G^(1)/G^(2) as a module over G/G^(1) (here G^(n) is the n-th term of the derived series of G). Hence any phenomenon associated to G^(2) is invisible to abelian invariants. This paper begins the systematic study of invariants associated to solvable covering spaces of knot exteriors, in particular the study of what we call the n-th higher-order Alexander module, G^(n+1)/G^(n+2), considered as a Z[G/G^(n+1)$-module. We show that these modules share almost all of the properties of the classical Alexander module. They are torsion modules with higher-order Alexander polynomials whose degrees give lower bounds for the knot genus. The modules have presentation matrices derived either from a group presentation or from a Seifert surface. They admit higher-order linking forms exhibiting self-duality. There are applications to estimating knot genus and to detecting fibered, prime and alternating knots. There are also surprising applications to detecting symplectic structures on 4-manifolds. These modules are similar to but different from those considered by the author, Kent Orr and Peter Teichner and are special cases of the modules considered subsequently by Shelly Harvey for arbitrary 3-manifolds.Comment: Published by Algebraic and Geometric Topology at http://www.maths.warwick.ac.uk/agt/AGTVol4/agt-4-19.abs.htm

Diagnosing foot infection in diabetes

Infection represents the presence of an inflammatory response and tissue injury due to the interaction of the host with multiplying bacteria. The disease spectrum is a consequence of the variability in these interactions. Diabetes, because of its effects on the vascular, neurological, and immune systems, can compromise the local and systemic response to infection, potentially masking the typical clinical features and hindering diagnosis. The early recognition of infection, particularly osteomyelitis, is paramount in the management of diabetic foot disease. Careful clinical appraisal remains the cornerstone of the assessment. Hematologic, biochemical, and radiological investigations are important aids in assessing the severity of infection. Microbiological assessment, particularly in more severe infection, requires good-quality samples, combined with rapid transport in an appropriate medium and effective communication with the laboratory. A focused, systematic approach to the accurate diagnosis and treatment of infection, combined with careful monitoring, ensures the maintenance of optimal management

Dust-temperature of an isolated star-forming cloud: Herschel observations of the Bok globule CB244

We present Herschel observations of the isolated, low-mass star-forming Bok globule CB244. It contains two cold sources, a low-mass Class 0 protostar and a starless core, which is likely to be prestellar in nature, separated by 90 arcsec (~ 18000 AU). The Herschel data sample the peak of the Planck spectrum for these sources, and are therefore ideal for dust-temperature and column density modeling. With these data and a near-IR extinction map, the MIPS 70 micron mosaic, the SCUBA 850 micron map, and the IRAM 1.3 mm map, we model the dust-temperature and column density of CB244 and present the first measured dust-temperature map of an entire star-forming molecular cloud. We find that the column-averaged dust-temperature near the protostar is ~ 17.7 K, while for the starless core it is ~ 10.6K, and that the effect of external heating causes the cloud dust-temperature to rise to ~ 17 K where the hydrogen column density drops below 10^21 cm^-2. The total hydrogen mass of CB244 (assuming a distance of 200 pc) is 15 +/- 5 M_sun. The mass of the protostellar core is 1.6 +/- 0.1 M_sun and the mass of the starless core is 5 +/- 2 M_sun, indicating that ~ 45% of the mass in the globule is participating in the star-formation process.Comment: Accepted for A&A Herschel Special Issue; 5 pages, 2 figure