Relational geographies of urban unsustainability: The entanglement of Californias housing crisis with WUI growth and climate change.

One of Californias most pressing social and environmental challenges is the rapid expansion of the wildlands-urban interface (WUI). Multiple issues associated with WUI growth compared to more dense and compact urban form are of concern-including greatly increased fire risk, greenhouse gas emissions, and fragmentation of habitat. However, little is understood about the factors driving this growth in the first place and, specifically, its relationship to urban-regional housing dynamics. This paper connects work in urban social science, urban and regional planning, and natural sciences to highlight the potential role of housing crises in driving displacement from the urban core to relatively more affordable exurbs, and with this, WUI growth. We analyze this relationship in California, which leads the nation in lack of affordable housing, scale of WUI growth, and many associated WUI hazards, including wildfire. We offer three related arguments: first, that Californias affordable housing crisis, with its effect of driving migration to exurban areas, should be recognized as a significant urban form-related sustainability challenge; second, that to understand this challenge scholars must expand the spatial scale and analytic toolkit of both urban and WUI analysis through relational, mixed methods research; and third, that political and programmatic efforts to address Californias housing crisis should undergird efforts to address WUI growth and climate change. Ultimately, we argue that expanding access to affordable urban housing can produce a more sustainable and just urban form that mitigates WUI-related climate and environmental impacts and reduces the vulnerability of growing numbers of WUI residents living in harms way

Designing Politics: the limits of design

What are the limits of design in addressing the political and/or when has design not been enough? A collection of thought pieces written by Theatrum Mundi’s Designing Politics Working Group following a workshop at the Villa Vassilieff in Paris on 25th May 2016. This working group is supported by the Global Cities Chair at the Fondation Maison des Sciences de l’Homme in Paris

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

More than Exception: Categories and the Problem of “Nature” in the Ruhr

This essay reflects on the conceptualisation of the Ruhr region as an urban and historical research object in English-language scholarship and the effects of this understanding on historical social analysis. It focuses particularly on how signs of “nature” – in the form of green space incorporated into industrial workers’ colony housing (Arbeitersiedlungen) around the turn of the last century – have been seen as “exceptions” in an industrial environment, and are subsequently interpreted as indicators of anti-modern values or pre-industrial ideals. I argue that this is the result of the production-centric frame that has dominated urban and historical analysis in the Ruhr, and suggest an alternative interpretation. These are new uses of green space that emerged through industrialisation and urbanisation, and that reflect a modern sensibility towards “nature”: one in which these material referents become legible as vehicles for social goods

Building more epistemically inclusive and environmentally equitable universities

Abstract: Higher educational institutions tend to draw from mainstream approaches to environmentalism that reinforce race, class, and gender hierarchies around who constitutes “an environmentalist” and what activities constitute “environmentalism.” As a result, students of color and students from other marginalized backgrounds who often experience environmental degradation and catastrophe firsthand do not often see their experiences reflected in universities’ environmental programming, curricula, or research. Furthermore, faculty and staff who center issues of race, equity, power, and justice when addressing environmental topics tend to work in isolation from one another and their efforts are not well-coordinated. In this paper, we draw from the concept of “epistemic exclusion” (Settles et al. J Divers High Educ 14:493, 2021; J High Educ 93:31–55, 2022) to explain hidden biases that systematically devalue scholarship that does not fit mainstream parameters. We describe a research project focused on building more equity-centered environmental efforts at the University of California, Santa Cruz. We find that faculty and staff across divisions want to engage in more epistemically inclusive and equity-centered environmental work, but lack the institutional support and resources (e.g., knowledge, funding, time, incentives) to do so. Interestingly, only a few responses focused on the barriers and biases related to epistemic exclusion. Our findings suggest that more awareness is needed to identify, analyze, and challenge these less visible barriers to substantively work towards greater inclusivity in environmentalism

Missing the Housing for the Trees: Equity in Urban Climate Planning

This paper examines equity’s incorporation into Climate Action Plans (CAPs), an increasingly important part of the urban sustainability planning landscape. We conduct a content analysis of 170 California CAPs and compare the plans’ treatment of equity to city characteristics such as size and income inequality. We find that equity language correlates with an increased presence of more systemic policy interventions, such as dense and/or affordable housing, in CAPs. However, the majority of CAPs “miss the housing for the trees,” with green policy agendas, such as trees and open space, remaining more dominant. We also find little association between local inequalities and how CAPs incorporate equity goals

Planetary urbanization.

In the early 1970s, a young Marxist sociologist named Manuel Castells, then living in exile in Paris, began his soon-to-be-classic intervention, The Urban Question, by declaring his "astonishment" that debates on "urban problems" were becoming "an essential element in the policies of governments, in the concerns of the mass media and, consequently, in the everyday life of a large section of the population" (1977 [1972]: 1). For Castells, this astonishment was born of his orthodox Marxist assumption that the concern with urban questions was ideological. The real motor of social change, he believed, lay elsewhere, in working-class action and anti-imperialist mobilization. On this basis, Castells proceeded to deconstruct what he viewed as the prevalent "urban ideology" under postwar managerial capitalism: his theory took seriously the social construction of the urban phenomenon in academic and political discourse, but ultimately derived such representations from purportedly more foundational processes associated with capitalism and the state's role in the reproduction of labor power. Four decades after Castells's classic intervention, it is easy to confront early twenty-first-century discourse on urban questions with a similar sense of astonishment -not because it masks the operations of capitalism but because it has become one of the dominant metanarratives through which our current planetary situation is interpreted, both in academic circles and in the public sphere. Today advanced interdisciplinary education in urban social science, planning, and design T W E N T Y-F I R S T-C E N T U R Y U R B A N I S M This essay builds on many years of discussion and ongoing collaborative work with Christian Schmid of the ETH Zurich. I am grateful to Travis Bost and Nikos Katsikis of the Harvard Graduate School of Design for assistance with ideas and images. Research support was generously provided by the Weatherhead Center for International Affairs, Harvard University. Hillary Angelo, Eric Klinenberg, Peter Marcuse, Margit Mayer, Jen Petersen, Xuefei Ren, and David Wachsmuth provided invaluable feedback on earlier versions of the text. They are of course absolved of responsibility for its remaining limitations and blind spots

Meta-genome-wide association studies identify a locus on chromosome 1 and multiple variants in the MHC region for serum C-peptide in type 1 diabetes

Aims/hypothesis The aim of this study was to identify genetic variants associated with beta cell function in type 1 diabetes, as measured by serum C-peptide levels, through meta-genome-wide association studies (meta-GWAS). Methods: We performed a meta-GWAS to combine the results from five studies in type 1 diabetes with cross-sectionally measured stimulated, fasting or random C-peptide levels, including 3479 European participants. The p values across studies were combined, taking into account sample size and direction of effect. We also performed separate meta-GWAS for stimulated (n = 1303), fasting (n = 2019) and random (n = 1497) C-peptide levels. Results: In the meta-GWAS for stimulated/fasting/random C-peptide levels, a SNP on chromosome 1, rs559047 (Chr1:238753916, T>A, minor allele frequency [MAF] 0.24–0.26), was associated with C-peptide (p = 4.13 × 10−8), meeting the genome-wide significance threshold (p T, MAF 0.07–0.10, p = 8.43 × 10−8). In the stimulated C-peptide meta-GWAS, rs61211515 (Chr6:30100975, T/–, MAF 0.17–0.19) in the MHC region was associated with stimulated C-peptide (β [SE] = − 0.39 [0.07], p = 9.72 × 10−8). rs61211515 was also associated with the rate of stimulated C-peptide decline over time in a subset of individuals (n = 258) with annual repeated measures for up to 6 years (p = 0.02). In the meta-GWAS of random C-peptide, another MHC region, SNP rs3135002 (Chr6:32668439, C>A, MAF 0.02–0.06), was associated with C-peptide (p = 3.49 × 10−8). Conditional analyses suggested that the three identified variants in the MHC region were independent of each other. rs9260151 and rs3135002 have been associated with type 1 diabetes, whereas rs559047 and rs61211515 have not been associated with a risk of developing type 1 diabetes. Conclusions/interpretation We identified a locus on chromosome 1 and multiple variants in the MHC region, at least some of which were distinct from type 1 diabetes risk loci, that were associated with C-peptide, suggesting partly non-overlapping mechanisms for the development and progression of type 1 diabetes. These associations need to be validated in independent populations. Further investigations could provide insights into mechanisms of beta cell loss and opportunities to preserve beta cell function. Electronic supplementary material The online version of this article (10.1007/s00125-018-4555-9) contains peer-reviewed but unedited supplementary material, which is available to authorised users