Decreased plasma postheparin lipolytic activity in systemic lupus erythematosus

Plasma postheparin lipolytic activity (PHLA) was measured on 50 patients with systemic lupus erythematosus (SLE). Plasma PHLA was significantly decreased in SLE patients. This decrease was most striking in the acute phase of the disease. There was a close relationship between decreased PHLA and immunologic factors indicative of the acute phase of SLE. These immunologic factors included shaggy antinuclear antibody pattern, low serum complement titer, high DNA antibody titer, mixed cryoglobulin and lumpy glomerular pattern by immunofluorescent staining.</p

Absence of a liver-specific membrane protein in a strain of Chang cells

A strain of Chang cells, derived from a human liver line, was examined for the presence of a liver-specific membrane protein (LSP), as described by Meyer zum Buschenfelde. Indirect immunofluorescence and antisera to human, rat, and rabbit LSP were used to demonstrate that LSP was present on isolated human, rat, and rabbit hepatocytes but not on the Chang cells. The results indicate that these Chang cells do not possess the LSP. The use of Chang cells in the studies of liver immunopathology may not reflect a valid correlation with organ-specific events relevant to the LSP.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22558/1/0000103.pd

Acinar pancreatic tumor with metastatic fat necrosis

This report deals with a pancreatic tumor associated with metastatic fat necrosis. Our patient displayed the full gamut of nodular panniculitis, polyarthritis, fever, eosinophilia, hyperlipasemia, lytic bones lesions, and marrow fat necrosis. The rheumatologic features are reviewed. Elevated serum lipase is a most helpful laboratory confirmation. The tumor in our patient presented a difficult problem in classification. Although the appearance under light microscopy was most compatible with islet cell carcinoma or islet cell carcinoid, the ultrastructural characteristics were those of acinar carcinoma.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44384/1/10620_2005_Article_BF01071911.pd

In vitro morphological studies on antibody-dependent nonimmune lymphocyte-mediated cytotoxicity in chronic active liver disease

Using an in vitro system of antibody-dependent cellular cytotoxicity (ADCC), the killing effect of chronic liver disease sera on target Chang cells, mediated by effector nonimmune lymphocytes (NLy), was studied. NLy destroyed Chang cells in monolayers pretreated with sera of patients with chronic active liver disease (CALD). Sera from these patients with CALD, after receiving steroid therapy, demonstrated a significant decrease of the cytotoxic action of NLy. The target cells treated with sera of normal subjects or patients with chronic persistent hepatitis were only minimally affected. Morphological observations of the cytotoxic action in a CALD serum-treated group showed intimate contact between NLy and the target cells in the areas of the plaques, where large numbers of the target Chang cells were injured and were closely associated with effector NLy. The Chang cells developed cytoplasmic swelling. The surface became ruffled, and intracytoplasmic organelles displayed vesicular degeneration. Thereafter, cell rupture and fragmentation occurred. The sera in patients with CALD appear to possess a membrane reactive factor, presumably antibody, against the surface membrane of Chang cells. This immunological mode of reaction between the effectors and target cells (ADCC) may be important in the perpetuation and pathogenesis of hepatocyte death in CALD.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44386/1/10620_2005_Article_BF01073183.pd

スイラシトウサイボウブンピキジョニカンスルデンシケンビキョウテキケンキュウ

京都大学0048新制・課程博士医学博士甲第664号医博第281号新制||医||115(附属図書館)1354UT51-51-L98京都大学大学院医学研究科病理系専攻(主査)教授 岡本 耕造, 教授 早石 修, 教授 翠川 修学位規則第5条第1項該当Kyoto UniversityDA

Bilateral Simultaneous Oblique MR Imaging of the Proximal Femur

Oblique axial and oblique coronal MR images parallel to the femoral neck provide more valuable information concerning the proximal femur than orthogonal images. The main disadvantage of the unilateral oblique imaging is that the imaging time is significantly increased when both hips need to be imaged. If the bilateral oblique imaging is performed simultaneously, this increase in imaging time is eliminated because the scanning time for the bilateral oblique imaging and the orthogonal imaging is the same