Repeatability and Agreement of Macular Thickness Measurements Obtained with Two Different Scan Modes of the Optovue RTVue Optical Coherence Tomography Device

Objectives:To evaluate the repeatability and agreement of macular thickness measurements obtained with E-MM5 and MM6, two different scan modes, on the Optovue RTVue optic coherence tomography (OCT) device.Materials and Methods:Three consecutive macular thickness measurements in 30 healthy volunteers were taken using the OCT device E-MM5 and MM6 scan modes. The repeatability and agreement of these measurements obtained from the two scan modes and divided into nine anatomical regions based on early treatment diabetic retinopathy study were subjected to statistical analysis.Results:The mean age of the participants was 29.7±6.39 years. Intraclass correlation (all ICC values ≥0.86) and coefficient of variation (all coefficient of variation values ≤2%) analyses of consecutive OCT measurements in the nine regions of the macula obtained in both E-MM5 and MM6 scan modes gave high repeatability rates. Mean macular thickness values in the foveal region were 243.76±21.79 μm in E-MM5 mode and 247.04±19.83 μm in MM6 mode (p=0.543). Values for measurements obtained in E-MM5 and MM6 scan modes in parafoveal macular regions were also statistically similar (p>0.05 for all). However, a statistically significant difference was observed between the two modes in perifoveal macular measurements, except in the superior region.Conclusion:The Optovue RTVue OCT device gives highly repeatable measurement results for macular thicknesses in both E-MM5 and MM6 scan modes. However, it should be considered that measurements performed in E-MM5 and MM6 modes give different results in perifoveal regions

Evaluation of Retinal Changes Using Optical Coherence Tomography in a Pediatric Case of Susac Syndrome

Susac syndrome is a rare occlusive vasculopathy affecting the retina, inner ear and brain. The cause is unknown, although it generally affects young women. This syndrome can be difficult to diagnose because its signs can only be revealed by detailed examination. These signs are not always concomitant, but may appear at different times. This report describes a pediatric case who was diagnosed with Susac syndrome when retinal lesions were identified in the inactive period with the help of optical coherence tomography (OCT). The purpose of this case report is to emphasize the importance of OCT in clarifying undefined retinal changes in Susac syndrome

Pulsatile Ocular Blood Flow Analysis in Cases with Primary Open-angle Glaucoma, Ocular Hypertension and Normotensive Glaucoma

Pur po se: To investigate the pulsatile ocular blood flow (POBF) levels in cases with primary open-angle glaucoma (POAG), ocular hypertension (OHT) and normotensive glaucoma (NTG). Ma te ri al and Met hod: Totally 99 eyes of 30 POAG (Group 1), 21 OHT (Group 2), 23 NTG (Group 3) and 25 control (Group 4) cases were included in this study. In all cases, intraocular pressure (IOP) and POBF levels were measured by ocular blood flow analyzer. Differences between groups were analyzed statistically. Re sults: The mean ages of the groups were 54.37±8.05; 52.57±7; 52.26±6.08; and 51.96±10.28, respectively. While the average IOP levels of groups were 16.91±3.91; 24.05+2.11; 14.48±2.15; and 17.47±3.64 mmHg, respectively (p<0.0001), the mean POBF levels of groups were 16.15±5.14; 16.64±4.06; 15.95±4.48; 20.11±4.12 μl/s, respectively (p=0.004). There was statistically significant difference for both IOP and POBF between Group 3 and Group 4. For only IOP, there was statistically significant difference between Group 1 and Group 3 as well as between Group 2 and Groups 1, 3 and 4. There was also significant difference for only POBF between Group 1 and Group 4. In the whole study group, POBF levels did not demonstrate a significant correlation with age and IOP levels (p=0.39 and p=0.812, respectively). Dis cus si on: The levels of POBF were found to be lower in cases with POAG and NTG compared to control cases. This finding supports the vascular theory in glaucomatous optic nerve damage and can be used as a guide in the etiopathogenesis of glaucoma. (Turk J Ophthalmol 2012; 42: 125-3