Time dependence studies on giant magnetoresistive Co/Cu multilayers

Time dependence studies consisting of applying current steps at fixed applied fields have been carried out on bilinear and biquadratic giant magnetoresistive (GMR) Co/Cu multilayers in a temperature controlled environment. It has been shown that the voltage responses to current steps of these aged multilayers are greater in magnitude before field cycling compared to those made after field cycling. Normalized voltage measurements for some samples suggest a magnetic viscosity effect due to a current step at zero-field is present and before field cycling. The effect is reduced after field cycling. This behavior suggests that the effect being seen is purely magnetic in origin, as only the field is being varied. A ln( ) type function has been curve fitted to the zero field voltage response to a current step before field cycling. Voltage measurements made on the Co/Cu films at different field values show that as the applied fields are increased the voltage response has a reduced ln(t) character

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, which amplified the signaling of MC3R, a key nutritional sensor. Shared signals with menopause timing at genes involved in DNA damage response suggest that the ovarian reserve might signal centrally to trigger puberty. We also highlight body size-dependent and independent mechanisms that potentially link reproductive timing to later life disease

Offender profiles and crime scene patterns in Belgian sexual murders

This chapter reports on an original empirical study into the demographic and behavioral characteristics of 33 Belgian sexual murderers. The analysis of these offenders and their crimes identified two broad offense templates that typically characterize these crimes. These were, respectively, labeled ‘‘opportunistic-impulsive’’ and ‘‘sadist-calculator.’’ The similarities these templates bear to other international models in the area of sexual murder are also considered

Functional C1-inhibitor diagnostics in hereditary angioedema: Assay evaluation and recommendations

International audienceHereditary angioedema (HAE) is an autosomal dominant disease characterized by recurrent episodes of potentially life-threatening angioedema. The most widespread underlying genetic deficiency is a heterozygous deficiency of the serine protease inhibitor C1 esterase inhibitor (C1-Inh). In addition to low C4 levels, the most important laboratory parameter for correct diagnosis of HAE or angioedema due to acquired C1-Inh deficiency is reduced C1-Inh function (fC1-Inh). No direct recommendations about the assays for fC1-Inh or sample handling conditions are available, although this would prove especially useful when a laboratory first starts to offer assays on fC1-Inh for HAE diagnosis. In the present study we evaluated the performance of fC1-Inh assays in the 15 different laboratories that are specialised in HAE diagnostics and assessed inter-laboratory variation with each laboratory using their own assays and standards. A double-blind survey was conducted using plasma/serum samples from healthy donors and HAE patients and the uniformity of HAE diagnosis was evaluated. It can be concluded that the diagnosis of fC1-Inh deficiency was made correctly in most cases in this survey. We can recommend the chromogenic assay for the determination of fC1-Inh, while the complex ELISA needs further investigation