Population-wide persistent hemostatic changes after vaccination with ChAdOx1-S

Various vaccines were developed to reduce the spread of the Severe Acute Respiratory Syndrome Cov-2 (SARS-CoV-2) virus. Quickly after the start of vaccination, reports emerged that anti-SARS-CoV-2 vaccines, including ChAdOx1-S, could be associated with an increased risk of thrombosis. We investigated the hemostatic changes after ChAdOx1-S vaccination in 631 health care workers. Blood samples were collected 32 days on average after the second ChAdOx1-S vaccination, to evaluate hemostatic markers such as D-dimer, fibrinogen, α2-macroglobulin, FVIII and thrombin generation. Endothelial function was assessed by measuring Von Willebrand Factor (VWF) and active VWF. IL-6 and IL-10 were measured to study the activation of the immune system. Additionally, SARS-CoV-2 anti-nucleoside and anti-spike protein antibody titers were determined. Prothrombin and fibrinogen levels were significantly reduced after vaccination (−7.5% and −16.9%, p < 0.0001). Significantly more vaccinated subjects were outside the normal range compared to controls for prothrombin (42.1% vs. 26.4%, p = 0.026) and antithrombin (23.9% vs. 3.6%, p = 0.0010). Thrombin generation indicated a more procoagulant profile, characterized by a significantly shortened lag time (−11.3%, p < 0.0001) and time-to-peak (−13.0% and p < 0.0001) and an increased peak height (32.6%, p = 0.0015) in vaccinated subjects compared to unvaccinated controls. Increased VWF (+39.5%, p < 0.0001) and active VWF levels (+24.1 %, p < 0.0001) pointed toward endothelial activation, and IL-10 levels were significantly increased (9.29 pg/mL vs. 2.43 pg/mL, p = 0.032). The persistent increase of IL-10 indicates that the immune system remains active after ChAdOx1-S vaccination. This could trigger a pathophysiological mechanism causing an increased thrombin generation profile and vascular endothelial activation, which could subsequently result in and increased risk of thrombotic events

'Silence bleeds': Hamlet across borders : The Shakespearean Adaptations of Sulayman Al-Bassam

Original article can be found at: http://www.informaworld.com/smpp/title~content=t713734315~db=all Copyright Informa / Taylor and FrancisThis article addresses the writing and performance work of Anglo-Kuwaiti director Sulayman Al-Bassam, tracing the development of his various adaptations of Shakespeare's Hamlet into English and Arabic 'cross-cultural' versions between 2001 and 2007. Al-Bassam's work presents English as a 'language in translation'. His works move from early modern to modern English, from Arabized English to Arabic, from one linguistic and geographical location to another, their forms moulded and remoulded by complex cultural pressures. The study focuses on specific examples from three adaptations to show in practice how in these works English is 'constantly crossed, challenged and contested'Peer reviewedFinal Accepted Versio

Sometimes I Start out a Sentence in French et je la terminerai en anglais. Interference and Code-Switching in Louisiana

La langue française fut le parler d'usage en Louisiane until the arrival of the Carpet Baggers and their Yankee Constitution in 1868 established an anglophone bridgehead on which future generations were quick to build. By the 1930s, the offshore oil industry had caused anglo immigration to penetrate even the most fiercely francophone areas of the state : the result was the gradual breakdown of the French language. Nevertheless, the idea remains that Louisiana is a « French » state. Yet Louisi..

Translation, poetics and the stage : six French Hamlets.

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