Reduced gravity simulator Patent

Cable suspension and inclined walkway system for simulating reduced or zero gravity environment

Recombination lifetimes in gamma-irradiated P-type float zone silicon

Electron decay rate and absorption cross sections for electron holes and recombination in gamma irradiated n-type silico

Recombination lifetimes in gamma-irradiated silicon

Recombination lifetimes of minority carriers measured as function of temperature in silicon before and after irradiation by cobalt 60 gamma ray

Technique simulates effect of reduced gravity

To simulate the effects of lunar gravity, an arrangement of near-vertical cables has been devised. These suspend the test subject perpendicular to an inclined walkway to give the effect of reduced gravitational pull

High Resolution Laser Ultrasound Detection of Metal Defects

The standard for sensitive detection and resolution of defects in metal components is scanned focused immersion inspection to produce C-scans. Laser ultrasound, although successfully applied to composite inspection, has previously not produced comparable results in this arena

A Technique for Simulating Conditions of Walking and Performing Other Self-Locomotive Activities on the Lunar Terrain

One of the most important and probably the most interesting phase of a manned lunar mission will be the time the astronauts spend outside their vehicle on the moon's surface taking scientific measurements, exploring the surface features, surveying possible sites for a lunar base, inspecting their vehicle and preparing it for their return trip. Because the lunar gravity is only one-sixth that of the earth gravity, the explorers undoubtedly will have to adjust their accustomed methods of walking, climbing, jumping and performing other self-locomotive activities in order to carry out these various tasks. In as much as the over-all success of the lunar mission will depend to a large extent upon the self-reliance of the explorers, it will be necessary to have extensive knowledge of the effects of the moon's reduced gravity on the physical capabilities of man and of man's ability to adopt to the new environment prior to the planning and execution of the mission. At the present time there is a dearth of information on this subject due primarily to the lack of a practical technique for simulating the reduced gravity. Several techniques such as immersion in water and riding in an airplane flying a Keplerian trajectory have been used for zero-g or weightlessness studies to determine the physical capabilities of man but these techniques are limited in their usefulness either by restrictions imposed by the viscous effect of the water or by the short duration and small test area available in an airplane. Consequently, an effort was made at the NASA Langley Research Center to devise a new technique that would provide a realistic simlation of a reduced gravity for unlimited periods of time and allow freedom of movement over considerable distances. This paper concerns itself with a discussion of the newly developed simulation technique and a presentation of some preliminary results which were obtained utilizing a working model based on this scheme

APOE ε4 and exercise interact in a sex-specific manner to modulate dementia risk factors

Abstract Introduction: Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for Alzheimer\u27s disease and related dementias (ADRDs), affecting many different pathways that lead to cognitive decline. Exercise is one of the most widely proposed prevention and intervention strategies to mitigate risk and symptomology of ADRDs. Importantly, exercise and APOE ε4 affect similar processes in the body and brain. While both APOE ε4 and exercise have been studied extensively, their interactive effects are not well understood. Methods: To address this, male and female APOE ε3/ε3, APOE ε3/ε4, and APOE ε4/ε4 mice ran voluntarily from wean (1 month) to midlife (12 months). Longitudinal and cross-sectional phenotyping were performed on the periphery and the brain, assessing markers of risk for dementia such as weight, body composition, circulating cholesterol composition, murine daily activities, energy expenditure, and cortical and hippocampal transcriptional profiling. Results: Data revealed chronic running decreased age-dependent weight gain, lean and fat mass, and serum low-density lipoprotein concentration dependent on APOE genotype. Additionally, murine daily activities and energy expenditure were significantly influenced by an interaction between APOE genotype and running in both sexes. Transcriptional profiling of the cortex and hippocampus predicted that APOE genotype and running interact to affect numerous biological processes including vascular integrity, synaptic/neuronal health, cell motility, and mitochondrial metabolism, in a sex-specific manner. Discussion: These data in humanized mouse models provide compelling evidence that APOE genotype should be considered for population-based strategies that incorporate exercise to prevent ADRDs and other APOE-relevant diseases

Take the Monkey and Run

The common marmoset (Callithrix jacchus) is a small, New World primate that is used extensively in biomedical and behavioral research. This short-lived primate, with its small body size, ease of handling, and docile temperament, has emerged as a valuable model for aging and neurodegenerative research. A growing body of research has indicated exercise, aerobic exercise especially, imparts beneficial effects to normal aging. Understanding the mechanisms underlying these positive effects of exercise, and the degree to which exercise has neurotherapeutic effects, is an important research focus. Thus, developing techniques to engage marmosets in aerobic exercise would have great advantages

The APOEε3/ε4 Genotype Drives Distinct Gene Signatures in the Cortex of Young Mice

Introduction: Restrictions on existing APOE mouse models have impacted research toward understanding the strongest genetic risk factor contributing to Alzheimer\u27s disease (AD) and dementia, APOEε4 , by hindering observation of a key, common genotype in humans - APOEε3/ε4 . Human studies are typically underpowered to address APOEε4 allele risk as the APOEε4/ε4 genotype is rare, which leaves human and mouse research unsupported to evaluate the APOEε3/ε4 genotype on molecular and pathological risk for AD and dementia. Methods: As a part of MODEL-AD, we created and validated new versions of humanized APOEε3/ε3 and APOEε4/ε4 mouse strains that, due to unrestricted breeding, allow for the evaluation of the APOEε3/ε4 genotype. As biometric measures are often translatable between mouse and human, we profiled circulating lipid concentrations. We also performed transcriptional profiling of the cerebral cortex at 2 and 4 months (mos), comparing APOEε3/ε4 and APOEε4/ε4 to the reference APOEε3/ε3 using linear modeling and WGCNA. Further, APOE mice were exercised and compared to litter-matched sedentary controls, to evaluate the interaction between APOEε4 and exercise at a young age. Results: Expression of human APOE isoforms were confirmed in APOEε3/ε3, APOEε3/ε4 and APOEε4/ε4 mouse brains. At two mos, cholesterol composition was influenced by sex, but not APOE genotype. Results show that the APOEε3/ε4 and APOEε4/ε4 genotype exert differential effects on cortical gene expression. APOEε3/ε4 uniquely impacts \u27hormone regulation\u27 and \u27insulin signaling,\u27 terms absent in APOEε4/ε4 data. At four mos, cholesterol and triglyceride levels were affected by sex and activity, with only triglyceride levels influenced by APOE genotype. Linear modeling revealed APOEε3/ε4 , but not APOEε4/ε4 , affected \u27extracellular matrix\u27 and \u27blood coagulation\u27 related terms. We confirmed these results using WGCNA, indicating robust, yet subtle, transcriptional patterns. While there was little evidence of APOE genotype by exercise interaction on the cortical transcriptome at this young age, running was predicted to affect myelination and gliogenesis, independent of APOE genotype with few APOE genotype-specific affects identified. Discussion: APOEε4 allele dosage-specific effects were observed in circulating lipid levels and cortical transcriptional profiles. Future studies are needed to establish how these data may contribute to therapeutic development in APOEε3/ε4 and APOEε4/ε4 dementia patients