Is there a role for cervicography in the detection of premalignant lesions of the cervix uteri?

The characteristics of cervicography and the Papanicolaou smear test have been compared for the detection of cervix lesions classified as CIN I or more. A total of 4,015 women were entered into the study. The sensitivity of cervicography is significantly higher (McNemar test, P < 0.0001), but its specificity remains significantly lower (McNemar test, P < 0.0001), and its higher sensitivity does not apply to lesions classified as CIN II or more (high-grade lesions). Hence, if patients with a positive screen result are to be referred for colposcopy-biopsy, cervicography is not a suitable alternative to the smear test for the screening of cervical cancer. However, cervicography can be envisaged as a complementary tool to the smear test because of (a) its higher capability to detect high-grade lesions among women less than 35 years old and (b) its potential superiority in following low-grade lesions. It may also serve as a tool for quality assurance audit of the smear test

Quantification of glands and fat in breast tissue: An experimental determination

In breast surgery and anatomy, the composition of the breast itself could vary from patient to patient due to respective proportions of glandular and fatty tissue. There is no easy and reliable way to predict these proportions. The purpose of this study was to evaluate the respective proportions of glands and fat in breasts. By analysing mastectomy specimens we were able to quantify the amounts of glandular and fatty tissue in the resected breasts. Twenty one breasts were studied following mastectomy for pure in situ carcinomas. The total volume and weight of the specimens were recorded and completed by specific densities of glandular and fatty tissue for each breast. This group was submitted to a calculation of proportions of glands and fat. The percentage of fat volume in the total breast volume varied from 7 to 56% and the percentage of fat weight in the total breast weight varied from 3.6 to 37.6%. This great variability in the respective proportions of fat and glands in the evaluated specimens was not significantly correlated to age and body mass index.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Le cancer du sein: à propos des "In Situ".

Since the introduction of screening mammography, the proportion of ductal carcinoma in situ (DCIS) has significantly increased. Their early detection result in the majority of the cases in an exclusive radiologic expression and a histopathologic measure inferior to 20 mm. Newly formulated proposals of histologic classifications may permit in the future to identify subtypes of DCIS with a different clinical behaviour and prognosis. In analogy to the treatment's evolution for invasive mammary cancers, the concept of conservative breast surgery is evaluated in prospective randomized trials, together with the impact of adjuvant radiotherapy. Preliminary results report high survival rates, despite a considerable number of local recurrences. Radiotherapy seems not to reduce proportionally the risk for non-invasive and invasive recurrences.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Palliative chest wall reconstruction [2]

SCOPUS: le.jinfo:eu-repo/semantics/publishe

Immediate breast reconstruction with saline-filled implants: no interference with the oncologic outcome?

The possible adverse effects on cancer control due to immediate breast reconstruction have been addressed recently for both silicone-filled implants and flap reconstruction. To evaluate those possible effects after immediate breast reconstruction with saline-filled implants, 49 patients reconstructed with saline-filled breast implants at the Jules Bordet Cancer Institute were studied. Selection was only based on the possibility to find a matched patient. These patients were matched with a control group of 49 matched women with breast cancer treated in the same center by mastectomy without any type of breast reconstruction. The two groups were comparable according to age at diagnosis (within 3 years), year of diagnosis (same year), stage of the tumor, histology, and nodal status. The only difference between the two groups was that radiation therapy was applied to some of the patients who were not reconstructed (due to tumor location). The results show, in terms of local recurrences, distant metastasis, and deaths, no significant difference between the two groups, even for the irradiated patients, within a mean follow-up period of 72 months (range, 24 to 108) months.Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Immediate breast reconstruction with implants and adjuvant chemotherapy: a good option?

Immediate breast reconstruction using implants is a currently practiced intervention. However, it is exposed to the potential adverse effects of adjuvant therapies necessitated for cancer control. Patients with implants, receiving adjuvant chemotherapy, were compared with those not necessitating chemotherapy to evaluate the real impact of this combination of treatment modalities on the final outcome. Cosmetic results were not influenced by the adjunction of chemotherapy, but a higher rate of implant infection was observed in the chemotherapy group (10.7% versus 1.5% p = 0.0084). This observation needs to be kept in mind when selecting patients for immediate breast reconstruction with implants.Comparative StudyJournal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Mise au point: cancer du sein et grossesse. Revue de la littérature.

The pregnancy-associated breast cancer seems to have become increasingly common with a high frequency of advanced breast cancer with axillary node metastases and so associated with poor prognosis.English AbstractJournal ArticleReviewSCOPUS: re.jinfo:eu-repo/semantics/publishe

Chest coverage and reconstruction after recurrence of breast cancer

Large local recurrences of breast cancer require wide surgical excision and subsequent defect reconstruction. Fifteen patients having such resection and cover with pedicled flaps were reviewed. The flaps included 14 latissimus dorsi muscle, 2 rectus abdominis muscle and 1 pectoralis major muscle flap. There was only one local complication without delay in complete healing. The mean hospital stay was 11 days. All patients had dissemination of the disease in the follow-up period and 13 died of the disease (mean delay from reconstruction being 27 months). In such cases, the use of the latissimus dorsi muscle flap, if the thoracodorsal artery is present, seems to offer good tissue cover with little morbidity and allows for a quick recovery, which is mandatory since these patients have a short life expectancy. © Springer-Verlag 2002.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Approche diagnostique et thérapeutique minimaliste des cancers du sein débutant

info:eu-repo/semantics/publishe

III.3 Tamoxifen and endometrium: Preliminary results of a follow-up study

SCOPUS: cp.jinfo:eu-repo/semantics/publishe