Is the Neuraminidase Inhibitor Tamiflu Effective in the Treatment of Influenza?

Influenza is a disease that has caused the deaths of tens of millions people in the last century alone. The influenza neuraminidase protein is essential in the mechanism infection. It enables the virus to leave the infected cell and proliferate. Antiviral neuraminidase inhibitor drugs can be used for treatment. The drug Tamiflu is the standard of care for both treatment and prophylaxis of influenza. The Cochrane reports of 2009 and 2014 conclude that evidence is lacking to support this. Numerous bodies disagree. Cochrane also question the accuracy and credibility of many studies and agencies in support of Tamiflu. This paper explores the issues

MET: An Experimental System for Malicious Email Tracking

Despite the use of state of the art methods to protect against malicious programs, they continue to threaten and damage computer systems around the world. In this paper we present MET, the Malicious Email Tracking system, designed to automatically report statistics on the flow behavior of malicious software delivered via email attachments both at a local and global level. MET can help reduce the spread of malicious software worldwide, especially self-replicating viruses, as well as provide further insight toward minimizing damage caused by malicious programs in the future. In addition, the system can help system administrators detect all of the points of entry of a malicious email into a network. The core of MET's operation is a database of statistics about the trajectory of email attachments in and out of a network system, and the culling together of these statistics across networks to present a global view of the spread of the malicious software. From a statistical perspective sampling only a small amount of traffic (for example, .1 %) of a very large email stream is sufficient to detect suspicious or otherwise new email viruses that may be undetected by standard signature-based scanners. Therefore, relatively few MET installations would be necessary to gather sufficient data in order to provide broad protection services. Small scale simulations are presented to demonstrate MET in operation and suggests how detection of new virus propagations via flow statistics can be automated

Email Archive Analysis Through Graphical Visualization

The analysis of the vast storehouse of email content accumulated or produced by individual users has received relatively little attention other than for specific tasks such as spam and virus filtering. Current email analysis in standard client applications consists of keyword based matching techniques for filtering and expert driven manual exploration of email files. We have implemented a tool, called the Email Mining Toolkit (EMT) for analyzing email archives which includes a graphical display to explore relationships between users and groups of email users. The chronological flow of an email message can be analyzed by EMT. Our design goal is to embed the technology into standard email clients, such as Outlook, revealing far more information about a user's own email history than is otherwise now possible. In this paper we detail the visualization techniques implemented in EMT. We show the utility of these tools and underlying models for detecting email misuse such as viral propagation, and spam spread as examples

Modeling User Search-Behavior for Masquerade Detection

Masquerade attacks are a common security problem that is a consequence of identity theft. Prior work has focused on user command modeling to identify abnormal behavior indicative of impersonation. This paper extends prior work by modeling user search behavior to detect deviations indicating a masquerade attack. We hypothesize that each individual user knows their own file system well enough to search in a limited, targeted and unique fashion in order to find information germane to their current task. Masqueraders, on the other hand, will likely not know the file system and layout of another user's desktop, and would likely search more extensively and broadly in a manner that is different than the victim user being impersonated. We extend prior research by devising taxonomies of UNIX commands and Windows applications that are used to abstract sequences of user commands and actions. The experimental results show that modeling search behavior reliably detects all masqueraders with a very low false positive rate of 0.13%, far better than prior published results. The limited set of features used for search behavior modeling also results in large performance gains over the same modeling techniques that use larger sets of features

Post-Patch Retraining for Host-Based Anomaly Detection

Applying patches, although a disruptive activity, remains a vital part of software maintenance and defense. When host-based anomaly detection (AD) sensors monitor an application, patching the application requires a corresponding update of the sensor's behavioral model. Otherwise, the sensor may incorrectly classify new behavior as malicious (a false positive) or assert that old, incorrect behavior is normal (a false negative). Although the problem of "model drift" is an almost universally acknowledged hazard for AD sensors, relatively little work has been done to understand the process of re-training a "live" AD model --- especially in response to legal behavioral updates like vendor patches or repairs produced by a self-healing system. We investigate the feasibility of automatically deriving and applying a "model patch" that describes the changes necessary to update a "reasonable" host-based AD behavioral model ({\it i.e.,} a model whose structure follows the core design principles of existing host--based anomaly models). We aim to avoid extensive retraining and regeneration of the entire AD model when only parts may have changed --- a task that seems especially undesirable after the exhaustive testing necessary to deploy a patch

Automated Social Hierarchy Detection through Email Network Analysis

We present our work on automatically extracting social hierarchies from electronic communication data. Data mining based on user behavior can be leveraged to analyze and catalog patterns of communications between entities to rank relationships. The advantage is that the analysis can be done in an automatic fashion and can adopt itself to organizational changes over time. We illustrate the algorithms over real world data using the Enron corporation's email archive. The results show great promise when compared to the corporations work chart and judicial proceeding analyzing the major players

Behavior Profiling of Email

This paper describes the forensic and intelligence analysis capabilities of the Email Mining Toolkit (EMT) under development at the Columbia Intrusion Detection (IDS) Lab. EMT provides the means of loading, parsing and analyzing email logs, including content, in a wide range of formats. Many tools and techniques have been available from the fields of Information Retrieval (IR) and Natural Language Processing (NLP) for analyzing documents of various sorts, including emails. EMT, however, extends these kinds of analyses with an entirely new set of analyses that model "user behavior." EMT thus models the behavior of individual user email accounts, or groups of accounts, including the "social cliques" revealed by a user's email behavior

Designing Host and Network Sensors to Mitigate the Insider Threat

We propose a design for insider threat detection that combines an array of complementary techniques that aims to detect evasive adversaries. We are motivated by real world incidents and our experience with building isolated detectors: such standalone mechanisms are often easily identified and avoided by malefactors. Our work-in-progress combines host-based user-event monitoring sensors with trap-based decoys and remote network detectors to track and correlate insider activity. We identify several challenges in scaling up, deploying, and validating our architecture in real environments

Behavior-Based Modeling and Its Application to Email Analysis

The Email Mining Toolkit (EMT) is a data mining system that computes behavior profiles or models of user email accounts. These models may be used for a multitude of tasks including forensic analyses and detection tasks of value to law enforcement and intelligence agencies, as well for as other typical tasks such as virus and spam detection. To demonstrate the power of the methods, we focus on the application of these models to detect the early onset of a viral propagation without "content-base" (or signature-based) analysis in common use in virus scanners. We present several experiments using real email from 15 users with injected simulated viral emails and describe how the combination of different behavior models improves overall detection rates. The performance results vary depending upon parameter settings, approaching 99% true positive (TP) (percentage of viral emails caught) in general cases and with 0.38% false positive (FP) (percentage of emails with attachments that are mislabeled as viral). The models used for this study are based upon volume and velocity statistics of a user's email rate and an analysis of the user's (social) cliques revealed in the person's email behavior. We show by way of simulation that virus propagations are detectable since viruses may emit emails at rates different than human behavior suggests is normal, and email is directed to groups of recipients in ways that violate the users' typical communications with their social groups

Human biallelic MFN2 mutations induce mitochondrial dysfunction, upper body adipose hyperplasia, and suppression of leptin expression

MFN2 encodes mitofusin 2, a membrane-bound mediator of mitochondrial membrane fusion and inter-organelle communication. MFN2 mutations cause axonal neuropathy, with associated lipodystrophy only occasionally noted, however homozygosity for the p.Arg707Trp mutation was recently associated with upper body adipose overgrowth. We describe similar massive adipose overgrowth with suppressed leptin expression in four further patients with biallelic MFN2 mutations and at least one p.Arg707Trp allele. Overgrown tissue was composed of normal-sized, UCP1-negative unilocular adipocytes, with mitochondrial network fragmentation, disorganised cristae, and increased autophagosomes. There was strong transcriptional evidence of mitochondrial stress signalling, increased protein synthesis, and suppression of signatures of cell death in affected tissue, whereas mitochondrial morphology and gene expression were normal in skin fibroblasts. These findings suggest that specific MFN2 mutations cause tissue-selective mitochondrial dysfunction with increased adipocyte proliferation and survival, confirm a novel form of excess adiposity with paradoxical suppression of leptin expression, and suggest potential targeted therapies