Recent findings about the deep scattering layer

Sound scattering observations in deep water are reported for the frequency range from 2 to 20 kc. An explosive sound source was employed to give a sound having high acoustic pressures throughout the frequency range. The receiver was directed vertically downward in the water; the recorder allowed simultaneous recording over several frequency bands...

Underwater camera positioning by sonar

Originally issued as Reference No. 60-17A pulse sonar system is described for measuring the height above the bottom of an underwater camera and other equipment in the deep oceans. Using this method, cameras have been positioned for photography at depths to about 2,500 fathoms with a precision of about half a fathom. The measurement is achieved by a sonar "pinger" on the equipment, which sends precise 1 pulse-per- second signals to the surface both directly and by reflection from the bottom.Undersea Warfare Branch, Office of Naval Research Under Contract Nonr-1367(00) (NR-261-102

Narrative of Chain cruise #43 : February - August 1964

Originally issued as Reference No. 65-9, series later renamed WHOI-.On CHAIN Cruise 43, 15 February to 21 August 1964, geophysical and geological observations were made in the North Atlantic Ocean, the Mediterranean and Red Seas, and the Western part of the Indian Ocean, along the track Woods Hole - Ceuta (Spanish Africa) - La Spezia - Port Said - Aden - Victoria (Seychelles Islands) - Port Louis (Mauritius) - Victoria (Seychelles Islands) - Port Said - Beirut - La Spezia - Monaco - Plymouth (England) - Woods Hole. This report contains (1) a narrative of the cruise, (2) a list of stations, (3) statements of the scientific objectives of the cruise, (4) a summary of the geological and geophysical observations, (5) end-of-cruise reports on equipment and some phases of the research program, and (6) a selection of bottom photographs. WHOI Ref. No. 64-51 contains a detailed navigational plot of the entire cruise, including soundings and the locations of other observations.This cruise was supported by the National Science Foundation under Grant GP-2370 and Submitted to the Office of Naval Research under Contract Nonr-4029(00) NR 260-101

An in vivo definition of brain histamine dynamics reveals critical neuromodulatory roles for this elusive messenger

Histamine is well known for mediating peripheral inflammation; however, this amine is also found in high concentrations in the brain where its roles are much less known. In vivo chemical dynamics are difficult to measure, thus fundamental aspects of histamine’s neurochemistry remain undefined. In this work, we undertake the first in-depth characterization of real time in vivo histamine dynamics using fast electrochemical tools. We find that histamine release is sensitive to pharmacological manipulation at the level of synthesis, packaging, autoreceptors and metabolism. We find two breakthrough aspects of histamine modulation. First, differences in H3 receptor regulation between sexes show that histamine release in female mice is much more tightly regulated than in male mice under H3 or inflammatory drug challenge. We hypothesize that this finding may contribute to hormone-mediated neuroprotection mechanisms in female mice. Second, a high dose of a commonly available antihistamine, the H1 receptor inverse agonist diphenhydramine, rapidly decreases serotonin levels. This finding highlights the sheer significance of pharmaceuticals on neuromodulation. Our study opens the path to better understanding and treating histamine related disorders of the brain (such as neuroinflammation), emphasizing that sex and modulation (of serotonin) are critical factors to consider when studying/designing new histamine targeting therapeutics

Seismic refraction measurements in the Atlantic Ocean Basin (Part one)

A reversed seismic refraction measurement was made 120 miles northwest of Bermuda (400 miles east of Cape Hatteras) in 2,800 fathoms of water. A velocity of 24,800 feet per second (7.58 km/sec.) for the second layer was identified with the ultrabasic layer of earthquake seismology. Assuming a velocity of 5,600 feet per second (1.70 km/sec.), clearly indicated by earlier measurements, a thickness of 4,500 feet was obtained for the sedimentary layer. The granitic and intermediate layers were absent

The Importance of Ethics and Ethical Leadership in the Accounting Profession

The emergence of the twenty-first century was plagued with extensive, evasive and disheartening leadership failures. Despite the accounting profession’s standards of professional ethics, it was also tainted with ethical leadership indiscretions during this era. In response to these ethical leadership failings, renewed interest in developing accounting professionals with strong ethical principles and ethical leadership behaviors has emerged. In many firms training and development of ethical behavior is now at the forefront of the firm’s communications and professional development efforts. The question remains however, can the profession instill in its members the importance of ethical conduct? Can ethical leaders be developed that model and monitor ethical behavior? In response to the call for leaders who are ethical and moral, this research examined a model that examines ethical leadership and its impact on leader effectiveness for leaders within the accounting industry. The analysis shows that ethical and transformational leadership make incremental independent contributions in explaining leader effectiveness. The study comments on how the findings that ethically and morally focused leaders may impact the accounting profession and restore an industry tarnished with accusations of unethical behavior to one that regains its original prominence based on consistent, moral, ethical, and effective leaders

ChEMBL: a large-scale bioactivity database for drug discovery

ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on a regular basis, then further curated and standardized to maximize their quality and utility across a wide range of chemical biology and drug-discovery research problems. Currently, the database contains 5.4 million bioactivity measurements for more than 1 million compounds and 5200 protein targets. Access is available through a web-based interface, data downloads and web services at: https://www.ebi.ac.uk/chembldb

What an Agile Leader Does: The Group Dynamics Perspective

When large industrial organizations change to (or start with) an agile approach to operations, managers and some employees are supposed to be “agile leaders” often without being given a clear definition of what that comprises when building agile teams. An inductive thematic analysis was used to investigate what 15 appointed leaders actually do and perceive as challenges regarding group dynamics working with an agile approach. Team maturity, Team design, and Culture and mindset were all categories of challenges related to group dynamics that the practitioners face and manage in their work-life that are not explicitly mentioned in the more process-focused agile transformation frameworks. The results suggest that leader mitigation of these three aspects of group dynamics is essential to the success of an agile transformation