16 research outputs found
An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development
A conserved injury-defense mechanism is present in plants and
animals, in which the production of reactive oxygen species (ROS)
and lipid metabolism are essential to the response. Here, we describe
that in the filamentous fungus Trichoderma atroviride, injury results
in the formation of asexual reproduction structures restricted to
regenerating cells. High-throughput RNA-seq analyses of the response
to injury in T. atroviride suggested an oxidative response
and activation of calcium-signaling pathways, as well as the participation
of lipid metabolism, in this phenomenon. Gene-replacement
experiments demonstrated that injury triggers NADPH oxidase
(Nox)–dependent ROS production and that Nox1 and NoxR are essential
for asexual development in response to damage. We further
provide evidence of Hâ‚‚Oâ‚‚ and oxylipin production that, as in plants
and animals, may act as signal molecules in response to injury in
fungi, suggesting that the three kingdoms share a conserved
defense-response mechanism