Cancer therapeutic potential of combinatorial immuno- and vaso-modulatory interventions

Currently, most of the basic mechanisms governing tumor-immune system interactions, in combination with modulations of tumor-associated vasculature, are far from being completely understood. Here, we propose a mathematical model of vascularized tumor growth, where the main novelty is the modeling of the interplay between functional tumor vasculature and effector cell recruitment dynamics. Parameters are calibrated on the basis of different in vivo immunocompromised Rag1-/- and wild-type (WT) BALB/c murine tumor growth experiments. The model analysis supports that tumor vasculature normalization can be a plausible and effective strategy to treat cancer when combined with appropriate immuno-stimulations. We find that improved levels of functional tumor vasculature, potentially mediated by normalization or stress alleviation strategies, can provide beneficial outcomes in terms of tumor burden reduction and growth control. Normalization of tumor blood vessels opens a therapeutic window of opportunity to augment the antitumor immune responses, as well as to reduce the intratumoral immunosuppression and induced-hypoxia due to vascular abnormalities. The potential success of normalizing tumor-associated vasculature closely depends on the effector cell recruitment dynamics and tumor sizes. Furthermore, an arbitrary increase of initial effector cell concentration does not necessarily imply a better tumor control. We evidence the existence of an optimal concentration range of effector cells for tumor shrinkage. Based on these findings, we suggest a theory-driven therapeutic proposal that optimally combines immuno- and vaso-modulatory interventions

Possible mechanism for achieving glass-like thermal conductivities in crystals with off-center atoms

In the filled Ga/Ge clathrate, Eu and Sr are off-center in site 2 but Ba is on-center. All three filler atoms (Ba,Eu,Sr) have low temperature Einstein modes; yet only for the Eu and Sr systems is there a large dip in the thermal conductivity, attributed to the Einstein modes. No dip is observed for Ba. Here we argue that it is the off-center displacement that is crucial for understanding this unexplained difference in behavior. It enhances the coupling between the "rattler" motion and the lattice phonons for the Eu and Sr systems, and turns on/off another scattering mechanism (for 1K < T < 20K) produced by the presence/absence of off-center sites. The random occupation of different off-center sites produces a high density of symmetry-breaking defects which scatters phonons. It may also be important for improving our understanding of other glassy systems.Comment: 4 pages, 1 figure (2 parts) -- v2: intro broadened; strengthened arguments regarding need for additional phonon scattering mechanis

Coulomb Blockade of Tunneling between Disordered Conductors

We determine the zero-bias anomaly of the conductance of tunnel junctions by an approach unifying the conventional Coulomb blockade theory for ultrasmall junctions with the diffusive anomalies in disordered conductors. Both, electron-electron interactions within the electrodes and electron-hole interactions between the electrodes are taken into account nonperturbatively. Explicit results are given for one- and two-dimensional junctions, and the crossover to ultrasmall junctions is discussed.Comment: 4 pages, 1 figure. Final version published in Phys. Rev. Let

Scanning-gate microscopy of semiconductor nanostructures: an overview

This paper presents an overview of scanning-gate microscopy applied to the imaging of electron transport through buried semiconductor nanostructures. After a brief description of the technique and of its possible artifacts, we give a summary of some of its most instructive achievements found in the literature and we present an updated review of our own research. It focuses on the imaging of GaInAs-based quantum rings both in the low magnetic field Aharonov-Bohm regime and in the high-field quantum Hall regime. In all of the given examples, we emphasize how a local-probe approach is able to shed new, or complementary, light on transport phenomena which are usually studied by means of macroscopic conductance measurements.Comment: Invited talk by SH at 39th "Jaszowiec" International School and Conference on the Physics of Semiconductors, Krynica-Zdroj, Poland, June 201

Charge order, dynamics, and magneto-structural transition in multiferroic LuFe2_2O4_4

We investigated the series of temperature and field-driven transitions in LuFe$_2$O$_4$ by optical and M\"{o}ssbauer spectroscopies, magnetization, and x-ray scattering in order to understand the interplay between charge, structure, and magnetism in this multiferroic material. We demonstrate that charge fluctuation has an onset well below the charge ordering transition, supporting the "order by fluctuation" mechanism for the development of charge order superstructure. Bragg splitting and large magneto optical contrast suggest a low temperature monoclinic distortion that can be driven by both temperature and magnetic field.Comment: 4 pages, 3 figures, PRL in prin

Centerscope

Centerscope, formerly Scope, was published by the Boston University Medical Center "to communicate the concern of the Medical Center for the development and maintenance of improved health care in contemporary society.

Thermodynamics of phantom black holes in Einstein-Maxwell-Dilaton theory

A thermodynamic analysis of the black hole solutions coming from the Einstein-Maxwell-Dilaton theory (EMD) in 4D is done. By consider the canonical and grand-canonical ensemble, we apply standard method as well as a recent method known as Geometrothermodynamics (GTD). We are particularly interested in the characteristics of the so called phantom black hole solutions. We will analyze the thermodynamics of these solutions, the points of phase transition and their extremal limit. Also the thermodynamic stability is analyzed. We obtain a mismatch of the between the results of the GTD method when compared with the ones obtained by the specific heat, revealing a weakness of the method, as well as possible limitations of its applicability to very pathological thermodynamic systems. We also found that normal and phantom solutions are locally and globally unstable, unless for certain values of the coupled constant of the EMD action. We also shown that the anti-Reissner-Nordstrom solution does not posses extremal limit nor phase transition points, contrary to the Reissner-Nordstrom case.Comment: 23 pages, version accepted for publication in Physical Review

On the Theory of Killing Orbits in Space-Time

This paper gives a theoretical discussion of the orbits and isotropies which arise in a space-time which admits a Lie algebra of Killing vector fields. The submanifold structure of the orbits is explored together with their induced Killing vector structure. A general decomposition of a space-time in terms of the nature and dimension of its orbits is given and the concept of stability and instability for orbits introduced. A general relation is shown linking the dimensions of the Killing algebra, the orbits and the isotropies. The well-behaved nature of "stable" orbits and the possible miss-behaviour of the "unstable" ones is pointed out and, in particular, the fact that independent Killing vector fields in space-time may not induce independent such vector fields on unstable orbits. Several examples are presented to exhibit these features. Finally, an appendix is given which revisits and attempts to clarify the well-known theorem of Fubini on the dimension of Killing orbits.Comment: Latex, 19 pages, no figur

Scattering theory for lattice operators in dimension d≥3d\geq 3

This paper analyzes the scattering theory for periodic tight-binding Hamiltonians perturbed by a finite range impurity. The classical energy gradient flow is used to construct a conjugate (or dilation) operator to the unperturbed Hamiltonian. For dimension $d\geq 3$ the wave operator is given by an explicit formula in terms of this dilation operator, the free resolvent and the perturbation. From this formula the scattering and time delay operators can be read off. Using the index theorem approach, a Levinson theorem is proved which also holds in presence of embedded eigenvalues and threshold singularities.Comment: Minor errors and misprints corrected; new result on absense of embedded eigenvalues for potential scattering; to appear in RM