Mean (standard deviation (SD)) baseline, follow-up (FU), and change scores on self-reported pain and function (WOMAC), physical health (PCS), and pain on physical examination (PE) for the total population and sub-groups.

‡<p>: statistically significant; the significance of physical health summary were tested by comparing the study sample with the norm based population (mean = 50, SD = 10).</p

Determinants for clinical progression over 6 years of lower limb osteoarthritis.

<p>^<i>1</i>except for determinants age, sex and BMI themselves, adjustment was made for age, sex and BMI.</p><p>^<i>2</i>multivariate model using a backward selection (R² = 48.6%). The independent variables with univariate associations with a p-value ≤0.10 were included.</p><p>Both models are calculated using approximation formula of Zhang.<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025426#pone.0025426-Zhang1" target="_blank">[19]</a>.</p>‡<p>: statistically significant.</p><p>Abbreviations: WOMAC: Western Ontario and McMaster Universities, JSN: joint space narrowing, na: not applicable.</p

Baseline characteristics of 168 patients with knee and/or hip OA stratified by availability of follow-up.

<p>*Patients may have OA at multiple joints at one time and can have pain in the knee and hip joint simultaneously. Abbreviation: IQR: interquartile range; BMI: Body Mass Index.</p

Determinants of good prognosis of lower limb osteoarthritis over 6 years.

1<p>except for determinants age, sex and BMI themselves, adjustment was made for age, sex and BMI.</p>2<p>multivariate model using a backward selection (R² = 43.3%). The independent variables with univariate associations with a p-value ≤0.10 were included.</p><p>Both models are calculated using approximation formula of Zhang.<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0025426#pone.0025426-Zhang1" target="_blank">[19]</a>.</p>‡<p>: statistically significant.</p><p>Abbreviations: WOMAC: Western Ontario and McMaster Universities, JSN: joint space narrowing, na: not applicable.</p

Cumulative probability plot of Western Ontario and McMaster Universities (WOMAC) scores change of patients without prosthesis during follow-up (n = 81) for WOMAC pain scores change (above) and WOMAC function scores change (below).

<p>The horizontal line above is the line set at minimal perceptible clinical improvement (MPCI) score which is used as the cut-off to define progression and the horizontal line below is the line set to define good prognosis.</p

Improvement in Health-Related Quality of Life and Satisfaction after Hip Replacement: A Comparison Between Patients with Mild to Moderate and Severe Radiographical Pre-Operative Osteoarthritis.

<p>Odds Ratios >1 indicate a higher probability of achieving a Minimal Clinically Important Difference in HRQoL after THR in patients with Kellgren Grade 3+4, compared to Grade 0–2.</p><p>The odds ratios adjusted for age, sex, Charnley Comorbidity Classification and BMI and stratified for quartiles of follow-up.</p

Patient Characteristics.

<p>All values are mean (SD), unless stated otherwise.</p

Patient Inclusion Flow-chart.

<p>Patient Inclusion Flow-chart.</p

Improvement in Health-Related Quality of Life and Satisfaction after Knee Replacement: A Comparison Between Patients with Mild to Moderate and Severe Radiographical Pre-Operative Osteoarthritis.

<p>Positive values indicate a higher mean improvement in HRQoL after THR in patients with Kellgren Grade 3+4, compared to Grade 0–2. The mean differences between radiographic severity are adjusted for age, sex, Charnley Comorbidity Classification and BMI and stratified for quartiles of follow-up.</p

Improvement in Health-Related Quality of Life and Satisfaction after Hip Replacement: A Comparison Between Patients with Mild to Moderate and Severe Radiographical Pre-Operative Osteoarthritis.

<p>Positive values indicate a higher mean improvement in HRQoL after THR in patients with Kellgren Grade 3+4, compared to Grade 0–2.</p><p>The mean differences between radiographic severity are adjusted for age, sex, Charnley Comorbidity Classification and BMI and stratified for quartiles of follow-up.</p