Smarter Programming of the Female Condom: Increasing Its Impact on HIV Prevention in the Developing World

The purpose of this study was to investigate the relative value of the female condom for HIV prevention within heterosexual relationships in the developing world. In the last ten years, the world has witnessed both historic financial commitments to HIV/AIDS and new prevention options, including biomedical prevention research, male circumcision, and a dramatic scale-up of voluntary counseling and testing. At the same time, where HIV remains at epidemic levels in many countries, there has been a growing commitment to treatment access alongside prevention programs. However, portions of populations, particularly youth and women, remain highly vulnerable to HIV infection. Accordingly, the global health community can benefit from a better understanding of how existing prevention options should be effectively and efficiently delivered to reduce HIV in the developing world. This report provides guidance for the global health community for considering how the female condom fits within the set of prevention interventions currently available

Deformation of Silica Aerogel During Fluid Adsorption

Aerogels are very compliant materials - even small stresses can lead to large deformations. In this paper we present measurements of the linear deformation of high porosity aerogels during adsorption of low surface tension fluids, performed using a Linear Variable Differential Transformer (LVDT). We show that the degree of deformation of the aerogel during capillary condensation scales with the surface tension, and extract the bulk modulus of the gel from the data. Furthermore we suggest limits on safe temperatures for filling and emptying low density aerogels with helium.Comment: 8 pages, 5 figures, submitted to PR

Компетентностный подход к управлению персоналом в нефтегазовой компании: особенности и совершенствование

Объектом исследования является применение компетентностного подхода в управлении персоналом нефтегазовой отрасли. Цель работы - анализ методов компетентностного подхода при оценке компетенций персонала в нефтегазовой отрасли, а также разработка практических рекомендаций по совершенствованию на примере ОАО "ТомскНИПИнефть".The object of the study is the application of a competence approach in the management of oil and gas industry personnel. The purpose of the work is to analyze the methods of the competence approach in assessing the competencies of personnel in the oil and gas industry, as well as developing practical recommendations for improving the example of OAO TomskNIPIneft

Emerging evidence for CHFR as a cancer biomarker : from tumor biology to precision medicine

Novel insights in the biology of cancer have switched the paradigm of a "one-size-fits-all" cancer treatment to an individualized biology-driven treatment approach. In recent years, a diversity of biomarkers and targeted therapies has been discovered. Although these examples accentuate the promise of personalized cancer treatment, for most cancers and cancer subgroups no biomarkers and effective targeted therapy are available. The great majority of patients still receive unselected standard therapies with no use of their individual molecular characteristics. Better knowledge about the underlying tumor biology will lead the way toward personalized cancer treatment. In this review, we summarize the evidence for a promising cancer biomarker: checkpoint with forkhead and ring finger domains (CHFR). CHFR is a mitotic checkpoint and tumor suppressor gene, which is inactivated in a diverse group of solid malignancies, mostly by promoter CpG island methylation. CHFR inactivation has shown to be an indicator of poor prognosis and sensitivity to taxane-based chemotherapy. Here we summarize the current knowledge of altered CHFR expression in cancer, the impact on tumor biology and implications for personalized cancer treatment

ZX-Calculus: Cyclotomic Supplementarity and Incompleteness for Clifford+T quantum mechanics

The ZX-Calculus is a powerful graphical language for quantum mechanics and quantum information processing. The completeness of the language -- i.e. the ability to derive any true equation -- is a crucial question. In the quest of a complete ZX-calculus, supplementarity has been recently proved to be necessary for quantum diagram reasoning (MFCS 2016). Roughly speaking, supplementarity consists in merging two subdiagrams when they are parameterized by antipodal angles. We introduce a generalised supplementarity -- called cyclotomic supplementarity -- which consists in merging n subdiagrams at once, when the n angles divide the circle into equal parts. We show that when n is an odd prime number, the cyclotomic supplementarity cannot be derived, leading to a countable family of new axioms for diagrammatic quantum reasoning.We exhibit another new simple axiom that cannot be derived from the existing rules of the ZX-Calculus, implying in particular the incompleteness of the language for the so-called Clifford+T quantum mechanics. We end up with a new axiomatisation of an extended ZX-Calculus, including an axiom schema for the cyclotomic supplementarity.Comment: Mathematical Foundations of Computer Science, Aug 2017, Aalborg, Denmar

MEMS/ECD Method for Making Bi(2-x)Sb(x)Te3 Thermoelectric Devices

A method of fabricating Bi(2-x)Sb(x)Te3-based thermoelectric microdevices involves a combination of (1) techniques used previously in the fabrication of integrated circuits and of microelectromechanical systems (MEMS) and (2) a relatively inexpensive MEMS-oriented electrochemical-deposition (ECD) technique. The present method overcomes the limitations of prior MEMS fabrication techniques and makes it possible to satisfy requirements

PcG Proteins, DNA Methylation, and Gene Repression by Chromatin Looping

Many DNA hypermethylated and epigenetically silenced genes in adult cancers are Polycomb group (PcG) marked in embryonic stem (ES) cells. We show that a large region upstream (∼30 kb) of and extending ∼60 kb around one such gene, GATA-4, is organized—in Tera-2 undifferentiated embryonic carcinoma (EC) cells—in a topologically complex multi-loop conformation that is formed by multiple internal long-range contact regions near areas enriched for EZH2, other PcG proteins, and the signature PcG histone mark, H3K27me3. Small interfering RNA (siRNA)–mediated depletion of EZH2 in undifferentiated Tera-2 cells leads to a significant reduction in the frequency of long-range associations at the GATA-4 locus, seemingly dependent on affecting the H3K27me3 enrichments around those chromatin regions, accompanied by a modest increase in GATA-4 transcription. The chromatin loops completely dissolve, accompanied by loss of PcG proteins and H3K27me3 marks, when Tera-2 cells receive differentiation signals which induce a ∼60-fold increase in GATA-4 expression. In colon cancer cells, however, the frequency of the long-range interactions are increased in a setting where GATA-4 has no basal transcription and the loops encompass multiple, abnormally DNA hypermethylated CpG islands, and the methyl-cytosine binding protein MBD2 is localized to these CpG islands, including ones near the gene promoter. Removing DNA methylation through genetic disruption of DNA methyltransferases (DKO cells) leads to loss of MBD2 occupancy and to a decrease in the frequency of long-range contacts, such that these now more resemble those in undifferentiated Tera-2 cells. Our findings reveal unexpected similarities in higher order chromatin conformation between stem/precursor cells and adult cancers. We also provide novel insight that PcG-occupied and H3K27me3-enriched regions can form chromatin loops and physically interact in cis around a single gene in mammalian cells. The loops associate with a poised, low transcription state in EC cells and, with the addition of DNA methylation, completely repressed transcription in adult cancer cells