12 research outputs found

    Viral nanomotors for packaging of dsDNA and dsRNA

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    While capsid proteins are assembled around single-stranded genomic DNA or RNA in rod-shaped viruses, the lengthy double-stranded genome of other viruses is packaged forcefully within a preformed protein shell. This entropically unfavourable DNA or RNA packaging is accomplished by an ATP-driven viral nanomotor, which is mainly composed of two components, the oligomerized channel and the packaging enzymes. This intriguing DNA or RNA packaging process has provoked interest among virologists, bacteriologists, biochemists, biophysicists, chemists, structural biologists and computational scientists alike, especially those interested in nanotechnology, nanomedicine, AAA+ family proteins, energy conversion, cell membrane transport, DNA or RNA replication and antiviral therapy. This review mainly focuses on the motors of double-stranded DNA viruses, but double-stranded RNA viral motors are also discussed due to interesting similarities. The novel and ingenious configuration of these nanomotors has inspired the development of biomimetics for nanodevices. Advances in structural and functional studies have increased our understanding of the molecular basis of biological movement to the point where we can begin thinking about possible applications of the viral DNA packaging motor in nanotechnology and medical applications

    Labor and energy impacts of energy conservation measures. First quarterly progress report

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    Work has progressed along two lines: obtaining of detailed occupation, industry, wage, and skill information; and obtaining of detailed materials and labor requirements (so-called direct requirements) for conservation and solar options. The latter is currently focused upon thermally tight single-family residences (vs. as-built). Both of these inputs will be used in conjunction with our input-output employment-energy model

    Sustainability Assessment Tools – State of Research and Gap Analysis

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    This paper investigates the current tools and frameworks for sustainability development assessments in industrial sectors and aims to find out the gaps between theory and practice toward sustainability assessments. An analysis of existing literature in the area of sustainability assessment tools has been complemented by interviews with experts in the area of sustainability and energy efficiency. Based on the body of knowledge and the practitioner feedback, time required and specificity are key challenges in sustainability development analysis. The paper opens the room for ideas concerning future research initiatives to overcome those drawbacks and challenge
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