IL-4 inhibits LPS-, IL-1β- and TNFα-induced expression of tissue factor in endothelial cells and monocytes

AbstractInflammatory mediators such as endotoxin, interleukin-1β(IL-1β) and tumor necrosis factors-α (TNF-α) dose-dependently increased the expression of tissue factor on the surface of cultured bovine aortic endothelial cells (ABAE), human umbilical vein endothelial cells (HUVEC) and human monocytes. In ABAE, endotoxin-, IL-1β- and TNFα-induced tissue factor expression was suppressed by interleukin-4 (IL-4) which also neutralized the pyrogenic effect of endotoxin in HUVEC and monocytes. IL-4 did not alter TNF-α-induced procoagulant changes in HUVEC and monocytes but strongly protected the monocyte surface against IL-1β-induced procoagulant changes

Infinite N phase transitions in continuum Wilson loop operators

We define smoothed Wilson loop operators on a four dimensional lattice and check numerically that they have a finite and nontrivial continuum limit. The continuum operators maintain their character as unitary matrices and undergo a phase transition at infinite N reflected by the eigenvalue distribution closing a gap in its spectrum when the defining smooth loop is dilated from a small size to a large one. If this large N phase transition belongs to a solvable universality class one might be able to calculate analytically the string tension in terms of the perturbative Lambda-parameter. This would be achieved by matching instanton results for small loops to the relevant large-N-universal function which, in turn, would be matched for large loops to an effective string theory. Similarities between our findings and known analytical results in two dimensional space-time indicate that the phase transitions we found only affect the eigenvalue distribution, but the traces of finite powers of the Wilson loop operators stay smooth under scaling.Comment: 31 pages, 9 figures, typos and references corrected, minor clarifications adde

Stabilization of Hydrodynamic Flows by Small Viscosity Variations

Motivated by the large effect of turbulent drag reduction by minute concentrations of polymers we study the effects of a weakly space-dependent viscosity on the stability of hydrodynamic flows. In a recent Letter [Phys. Rev. Lett. {\bf 87}, 174501, (2001)] we exposed the crucial role played by a localized region where the energy of fluctuations is produced by interactions with the mean flow (the "critical layer"). We showed that a layer of weakly space-dependent viscosity placed near the critical layer can have a very large stabilizing effect on hydrodynamic fluctuations, retarding significantly the onset of turbulence. In this paper we extend these observation in two directions: first we show that the strong stabilization of the primary instability is also obtained when the viscosity profile is realistic (inferred from simulations of turbulent flows with a small concentration of polymers). Second, we analyze the secondary instability (around the time-dependent primary instability) and find similar strong stabilization. Since the secondary instability develops around a time-dependent solution and is three-dimensional, this brings us closer to the turbulent case. We reiterate that the large effect is {\em not} due to a modified dissipation (as is assumed in some theories of drag reduction), but due to reduced energy intake from the mean flow to the fluctuations. We propose that similar physics act in turbulent drag reduction.Comment: 10 pages, 17 figs., REVTeX4, PRE, submitte

On the consistent solution of the gap--equation for spontaneously broken λΦ4\lambda \Phi^4-theory

We present a self--consistent solution of the finite temperature gap--equation for $\lambda \Phi^4$ theory beyond the Hartree-Fock approximation using a composite operator effective action. We find that in a spontaneously broken theory not only the so--called daisy and superdaisy graphs contribute to the resummed mass, but also resummed non--local diagrams are of the same order, thus altering the effective mass for small values of the latter.Comment: 15 pages of revtex + 3 uuencoded postscript figures, ENSLAPP A-488/9

Superdiffusivity of the 1D lattice Kardar-Parisi-Zhang equation

The continuum Kardar-Parisi-Zhang equation in one dimension is lattice discretized in such a way that the drift part is divergence free. This allows to determine explicitly the stationary measures. We map the lattice KPZ equation to a bosonic field theory which has a cubic anti-hermitian nonlinearity. Thereby it is established that the stationary two-point function spreads superdiffusively.Comment: 21 page

Strong Tunneling in Double-Island Structures

We study the electron transport through a system of two low-capacitance metal islands connected in series between two electrodes. The work is motivated in part by experiments on semiconducting double-dots, which show intriguing effects arising from coherent tunneling of electrons and mixing of the single-electron states across tunneling barriers. In this article, we show how coherent tunneling affects metallic systems and leads to a mixing of the macroscopic charge states across the barriers. We apply a recently formulated RG approach to examine the linear response of the system with high tunnel conductances (up to 8e^2/h). In addition we calculate the (second order) cotunneling contributions to the non-linear conductance. Our main results are that the peaks in the linear and nonlinear conductance as a function of the gate voltage are reduced and broadened in an asymmetric way, as well as shifted in their positions. In the limit where the two islands are coupled weakly to the electrodes, we compare to theoretical results obtained by Golden and Halperin and Matveev et al. In the opposite case when the two islands are coupled more strongly to the leads than to each other, the peaks are found to shift, in qualitative agreement with the recent prediction of Andrei et al. for a similar double-dot system which exhibits a phase transition.Comment: 12 page