Functional Design Employing Miniaturized Electronics with Wireless Signal Provision to a Smartphone for a Strain-Based Measuring System for Ski Poles

The individual monitoring of cross-country skiers’ technique-related parameters is crucial to identifying possible athlete-individual deficits that need to be corrected in order to optimize the athlete’s performance in competition. To be able to record relevant biomechanical parameters during training in the field, the development of measuring systems exploiting the athlete’s full potential is the key. Known mobile monitoring systems for measuring forces on ski poles use comparably heavy uniaxial load cells mounted on the pole with a data logger also attached to the pole or carried by the athlete. Measurements that are more accurate can be acquired using wire-based systems. However, wire-based systems are highly immobile and only usable when the athletes undergo a stationary test, e.g., on a treadmill. This paper focuses on the functional design of a measuring system using specialized, miniaturized electronics for acquiring data from strain sensors. These data are then used to determine the technique-related parameters pole force and angle of bend. The functional design is also capable of transmitting the acquired data wirelessly via Bluetooth to a smartphone that runs a proprietary app. This approach is advantageous regarding mass, dynamic behavior, analyzing functionality, and signal processing compared to the state of the art

Analysis of Performance Instabilities of Hafnia-Based Ferroelectrics Using Modulus Spectroscopy and Thermally Stimulated Depolarization Currents

The discovery of the ferroelectric orthorhombic phase in doped hafnia films has sparked immense research efforts. Presently, a major obstacle for hafnia's use in high-endurance memory applications like nonvolatile random-access memories is its unstable ferroelectric response during field cycling. Different mechanisms are proposed to explain this instability including field-induced phase change, electron trapping, and oxygen vacancy diffusion. However, none of these is able to fully explain the complete behavior and interdependencies of these phenomena. Up to now, no complete root cause for fatigue, wake-up, and imprint effects is presented. In this study, the first evidence for the presence of singly and doubly positively charged oxygen vacancies in hafnia–zirconia films using thermally stimulated currents and impedance spectroscopy is presented. Moreover, it is shown that interaction of these defects with electrons at the interfaces to the electrodes may cause the observed instability of the ferroelectric performance

Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma

Objective: To explore an association with survival of modifying the current standard of care for patients with newly diagnosed glioblastoma of surgery followed by radiotherapy plus concurrent and 6 cycles of maintenance temozolomide chemotherapy (TMZ/RT -> TMZ) by extending TMZ beyond 6 cycles. Methods: The German Glioma Network cohort was screened for patients with newly diagnosed glioblastoma who received TMZ/RT -> TMZ and completed >6 cycles of maintenance chemotherapy without progression. Associations of clinical patient characteristics, molecular markers, and residual tumor determined by magnetic resonance imaging after 6 cycles of TMZ with progression-free survival (PFS) and overall survival (OS) were analyzed with the log-rank test. Multivariate analyses using the Cox proportional hazards model were performed to assess associations of prolonged TMZ use with outcome. Results: Sixty-one of 142 identified patients received at least 7 maintenance TMZ cycles (median 11, range 7-20). Patients with extended maintenance TMZ treatment had better PFS (20.5 months, 95% confidence interval [CI] 17.7-23.3, vs 17.2 months, 95% CI 10.2-24.2, p = 0.035) but not OS (32.6 months, 95% CI 28.9-36.4, vs 33.2 months, 95% CI 25.3-41.0, p = 0.126). However, there was no significant association of prolonged TMZ chemotherapy with PFS (hazard ratio [HR] 5 0.8, 95% CI 0.4-1.6, p = 0.559) or OS (HR 5 1.6, 95% CI 0.8-3.3, p = 0.218) adjusted for age, extent of resection, Karnofsky performance score, presence of residual tumor, O-6-methylguanine DNA methyltransferase (MGMT) promoter methylation status, or isocitrate dehydrogenase (IDH) mutation status. Conclusion: These data may not support the practice of prolonging maintenance TMZ chemotherapy beyond 6 cycles. Classification of evidence: This study provides Class III evidence that in patients with newly diagnosed glioblastoma, prolonged TMZ chemotherapy does not significantly increase PFS or OS

Genome-wide association and functional follow-up reveals new loci for kidney function

Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and stratified for key CKD risk factors. We uncovered 6 new loci in association with estimated glomerular filtration rate (eGFR), the primary clinical measure of CKD, in or near MPPED2, DDX1, SLC47A1, CDK12, CASP9, and INO80. Morpholino knockdown of mpped2 and casp9 in zebrafish embryos revealed podocyte and tubular abnormalities with altered dextran clearance, suggesting a role for these genes in renal function. By providing new insights into genes that regulate renal function, these results could further our understanding of the pathogenesis of CKD

Aktualgenetische Psychophysiologie im Spiegel des post-positivistischen Relevanzparadigmas

Hentschel U. Aktualgenetische Psychophysiologie im Spiegel des post-positivistischen Relevanzparadigmas. Bielefelder Arbeiten zur Sozialpsychologie, 177. Bielefeld: Univ. Bielefeld, Fakultät für Soziologie; 1996

1750-1770 : ein 'goldenes' Zeitalter der deutschen Literatur?

Als Franz Horn, Vorreiter einer modernen Literaturgeschichtsschreibung, 1824 nach einer angemessenen Bezeichnung des Zeitraums zwischen 1750 und 1770 suchte, erinnerte er seine Leser daran, dass diese Jahre unlängst noch als das "goldene Zeitalter der deutschen Literatur" bezeichnet worden waren. Dessen Schriftsteller - so Horn bereits 1805 - hätten einen wichtigen Beitrag zum "Wiederaufblühen und der Reife unserer Literatur" geleistet. Genauso sahen es bis in die zweite Hälfte des 19. Jahrhunderts hinein zahlreiche Literaturhistoriker. Karl Herzog bilanziert 1831 die "Selbständigkeit der National-Literatur" unter der Überschrift "Von der Mitte des 18ten Jahrhunderts bis auf unsere Zeit"; für Christian Georg Friedrich Brederlow beginnt das "classische Zeitalter der deutschen Literatur" in der "Mitte des 18. Jahrhunderts", für Werner Hahn setzt die "Zeit der klassischen Vollendung der deutschen Poesie" mit "Klopstock 1748" ein, Karl Gustav Helbig periodisiert "vom zweiten Viertel des 18. Jahrhundert bis zur Gegenwart", Joseph Hillebrand spricht von einer "nationalliterarischen Reformation unter Lessing", was zugleich "der Anfang ihrer klassischen Wiedergeburt" gewesen sei, und Heinrich Laube sieht mit Lessing gar "diejenige Literatur, welche man die klassische nennt", beginnen. Was hier immer wieder wie eine zusammenhängende Periode erscheint, die ausgehend von der zweiten Hälfte des 18. Jahrhunderts bis zu seinem Ende reicht, sollte schon bald zu einem mehrstufigen Entwicklungsmodell ausdifferenziert werden, an dessen Ende die Weimarer Klassik steht - als mondäner Gipfel, der einen großen Schatten werfen wird auf die vermeintlichen Niederungen der Literaturlandschaft

El uso de los mecanismos de defensacomo herramientas de afrontamientopor veteranos israelíes deprimidos y con TEPT

Objective: to detect the defense mechanisms corresponding to PTSD (Post traumatic stress disorder) and depressed Israeli veterans and control group. Sample: 155 participants: control group (N=55), depressed veterans (N=39). veterans suffering from PTSD (N=61). Instruments: PTSD questionnaire, version for civilians, Hamilton scale. Questionnaire of Depressive Experiences (QDE), Life style index (LSI). Result: different combinations of defense mechanisms were detected in each of the studied groups. The group of the depressed reports greater use of regression, projection and reaction formation than the control group. Accordingly, the diagnosed groups use different defense mechanisms from those of the control group, therefore confirming the hypothesis. The individuals manifesting TEPT use intellectualization more than the depressed ones, so the hypothesis that there are differences between these two groups can be maintained.Objetivo: detectar los mecanismos de defensa correspondientes a veteranos con TEPT (Trastorno por Estrés Post-Traumático), deprimidos y controles. Muestra: 155 participantes: grupo control (N = 55), veteranos deprimidos (N=39), veteranos con TEPT (N=61). Instrumentos: cuestionario de TEPT versión para civiles, escala Hamilton, Cuestionario de Experiencias Depresivas (CED), Índice de Estilo de Vida (LSI). Resultado: se detectaron diferentes combinatorias de mecanismos de defensa en cada uno de los grupos estudiados. El grupo de deprimidos reporta un mayor uso de la regresión y la proyección que el grupo control. Los individuos con TEPT utilizan la proyección, regresión y formación reactiva más que el grupo control. Por consiguiente, los grupos diagnosticados utilizan mecanismos de defensa diferentes de los del grupo control, lo cual confirma la hipótesis. Los individuos con TEPT utilizan la intelectualización más que los deprimidos y, entonces, la hipótesis de que existen diferencias entre estos dos grupos también se sostiene