24 research outputs found

    Upper Nasopharyngeal Corridor for Transclival Endoscopic-Assisted Access to the Petrous Apex in Patients with Conchal Sphenoidal Anatomy: Application in Cholesterol Granulomas

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    Background: Cholesterol granulomas are benign cystic lesions arising in the petroclival region. Petroclival cholesterol granulomas (PCCGs) can be treated via traditional approaches such as infralabyrinthine, transcanal infracochlear, translabyrinthine, middle cranial fossa, and retrosigmoid routes or through less invasive endoscopic-assisted endonasal transphenoidal approaches. The latter approach requires access to the sphenoid sinus, visualization of the clival recess and bony landmarks to access the petrous apex (PA). However, in patients with poorly pneumatized (choncal) sphenoid sinus, access to the sphenoid sinus using the endoscopic endonasal transphenoidal approach is technically difficult and may not be feasible, necessitating an alternative approach. Methods: In this report, we present a case of a low-lying petroclival cholesterol granuloma in a patient with a conchal sphenoid and describe an alternative access corridor via an upper nasopharyngeal exposure that facilitated an endoscopic-assisted fenestration and drainage of the lesion. Presentation: A 55-year-old woman presented with hearing loss and tinnitus. CT showed a conchal sphenoid and a large lytic expansile mass with soft tissue density centered in the right PA with osseous remodeling. (Fig. 1鈥揅) MRI showed a nonenhancing right PA mass that measured 22 脳18 脳19鈥塵m with increased T1 and T2 signal, consistent with PCCG. (Fig. 1 D鈥揊). A transclival endoscopic-assisted approach was planned. Operative Technique: A standard image-guided approach including a right maxillary antrostomy, uncinectomy, and middle turbinectomy was performed. The upper nasopharyngeal mucosa and adenoid bed were then completely removed using coblation. A pedicled nasoseptal flap was harvested and mobilized toward the right maxillary sinus. A transclival exposure was performed with a high-speed diamond drill located inferior and medial to the vidian nerve. Intraoperative ultrasound and neuronavigation confirmed the course of the petroclival internal carotid arteries. Dissection of paraclival structures proceeded in a standard fashion until the cyst contents were reached. Following cyst evacuation, extensive drilling was performed medially, superiorly, and inferiorly to enlarge the size of the outflow tract and facilitate placement of the nasoseptal flap. Successful resection was verified by postoperative CT and MRI. (Fig. 2) Postoperative nasal endoscopy verified mucosalization of the drainage tract. Conclusion: In patients with a conchal sphenoid, an upper nasopharyngeal corridor provides adequate visualization for an endoscopic-assisted transclival approach, which was successfully used to treat a PCCG. Fig. 1 Preoperative CT showing lytic expansile soft tissue mass (A鈥揅) and preoperative MRI (D鈥揊) showing T1鈥揟2 hyperintensity consistent with cholesterol granuloma. Fig. 2 Postoperative CT and MR imaging showing postsurgical changes and resection cavity

    Endoscopic Sinus Surgery in Adults With Cystic Fibrosis Effect on Lung Function, Intravenous Antibiotic Use, and Hospitalization

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    Objective: To ascertain the effect of endoscopic sinus surgery (ESS) on lung function, intravenous (IV) antibiotic use, and hospitalization in adults with cystic fibrosis (CF). Design: Retrospective analysis. Settings: Tertiary care center. Patients: Fifteen adults with a diagnosis of CF undergoing ESS between March 1, 2006, and June 31, 2008. Main Outcome Measures: Twelve-month preoperative and 12-month postoperative pulmonary function testing ( forced vital capacity [FVC] and forced expired volume in 1 second [FEV1]), number of IV antibiotic courses, total number of days of intravenous antibiotic use, and number of inpatient hospital days (IHDs) were assessed. Results: Twenty-two adults with CF underwent ESS; 15 patients had adequate data for evaluation. No significant differences were found between mean preoperative and postoperative FEV1 (61.3% vs 59.5%; P =. 41) or FVC (76.4% vs 76.1%; P =. 97) or between best preoperative and postoperative FEV1 (67.4% vs 67.0%; P =. 95) or FVC (84.2% vs 83.0%; P =. 86) (paired samples t test). The number of IV antibiotic courses and the total number of days of IV antibiotic use did not differ between the preoperative and postoperative periods (Wilcoxon signed rank test P =. 61 and P =. 10, respectively). However, the number of IHDs was significantly lower in the 1-year postoperative period (36.7 days) vs the 1-year preoperative period (59.1 days) (Wilcoxon signed rank test, z =-2.20, P =. 03). Conclusions: This preliminary study of ESS in adult CF patients indicates significant reduction in the number of IHDs in the postoperative period. However, there is no evidence that ESS improved lung function or the need for IV antibiotics. Arch Otolaryngol Head Neck Surg. 2012;138(12):1167-117

    Review of Orbital Fractures in an Urban Level I Trauma Center

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    Objective: To perform a comprehensive review and analysis of surgically treated orbital fractures. Study Design: Retrospective cohort chart review study for surgically treated orbital fractures during 5 years. Results: A total of 173 patients (average age 41.6 years) were diagnosed with orbital fractures. Most were male with a ratio of 3.3:1. Most fractures were caused by assault (39.3%); 22.5% of the cases were bilateral. The left orbit (40.5%) was fractured more than the right. The orbital floor (97.1%) was the most common anatomic location and the maxilla (65.3%) was the most commonly involved bone. The average time from trauma to surgical intervention was 8.7 +/- 14.6 days and the average time from surgical intervention to discharge was 5.1 +/- 9.0 days. The transconjunctival incision (63%) was the most commonly used incision, and nonresorbable implant (92.7%) was the most commonly used implant. Finally, the length of stay for the repair of a simple orbital fracture was less than for complex orbital fracture (1.5 days and 5.9 days, respectively). Conclusion: Understanding the patterns and mechanisms of injury associated with orbital fractures can assist in developing standardized treatment protocols across all surgical specialties. This would ultimately allow for a uniform high quality of surgical care for patients with maxillofacial fractures

    Characterization of B-cell subpopulations in patients with chronic rhinosinusitis

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    Background: Recent research suggest that B and plasma cells may play an important role in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). The purpose of this study was to subcharacterize the B cell response in the sinus mucosa of control and CRS patients. Methods: Representative tissue samples and peripheral blood samples were obtained from controls, CRS without nasal polyps (CRSsNP) and CRSwNP. Using single-cell suspension flow cytometry these samples were analyzed for overall and stage-specific B and plasma cell percentages. Results: Both atopic and nonatopic CRSwNP patients showed an increase in local numbers of naive, active, and memory B cells compared to controls. CRSsNP patients only showed local elevations of naive B cells. Plasma cells were only significantly elevated in the sinus tissue of atopic CRSwNP patients. These local tissue increases did not correlate with increased numbers of circulating B cells. Conclusion: This study provides further evidence of an important role of B cells in CRSwNP patients. The local increase appears to be independent of a systemic response. (C) 2013 ARS-AAOA, LLC
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