REVERSIBILITE DES ALTERATIONS PULMONAIRES FONCTIONNELLES DANS LES AFFECTIONS VALVULAIRES MITRALES APRES CORRECTION CHIRURGICALE

In 44 patients undergoing operation for mitral disease, the pulmonary volumes, the pulmonary mechanics and the alveolocapillary transfer of CO were examined prior to the operation and 3 times postoperatively: in the 3rd or 4th wk, between the 3rd and 5th mth and between the 10th and 14th mth. During the immediate postoperative period an episode of considerable aggravation of functional impairment was observed which was not due exclusively to the surgical trauma of the chest wall but also to specific affection of the alveolocapillary membrane. One year postoperatively, the preoperative functional alterations were found to have only partially returned. In particular, the transfer of CO and the resistance of the respiratory tract remained abnormal even in cases running a favorable clinical course. The possible causes of these phenomena are discussed. (11 references).SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Liver-function studies in heart-transplant recipients treated with cyclosporin A

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Neuropeptides, New Ligands of SARS-CoV-2 Nucleoprotein, a Potential Link between Replication, Inflammation and Neurotransmission

This work identifies new ligands of the nucleoprotein N of SARS-CoV-2 by in silico screening, which used a new model of N, built from an Alphafold model refined by molecular dynamic simulations. The ligands were neuropeptides, such as substance P (1-7) and enkephalin, bound at a large site of the C-terminal or associated with the N-terminal β−sheet. The BA4 and BA5 Omicron variants of N also exhibited a large site as in wt N, and an increased flexibility of the BA5 variant, enabling substance P binding. The binding sites of some ligands deduced from modeling in wt N were assessed by mutation studies in surface plasmon resonance experiments. Dynamic light scattering showed that the ligands impeded RNA binding to N, which likely inhibited replication. We suggest that the physiological role of these neuropeptides in neurotransmission, pain and vasodilation for cholecystokinin and substance P could be altered by binding to N. We speculate that N may link between viral replication and multiple pathways leading to long COVID-19 symptoms. Therefore, N may constitute a “danger hub” that needs to be inhibited, even at high cost for the host. Antivirals targeted to N may therefore reduce the risk of brain fog and stroke, and improve patients’ health

Il y a 70 ans, Auschwitz. Retour sur Primo Levi

27 janvier 1945. Il y a 70 ans les premiers soldats de l’Armée rouge pénétraient dans le camp d’Auschwitz marquant définitivement ce que l’on pourrait appeler sa « libération », bien qu’Auschwitz n’ait été, pas plus qu’aucun autre camp nazi, un objectif prioritaire pour aucune des forces alliées. Primo Levi faisait partie des quelques rescapés qui, échappant aux évacuations forcées, étaient restés cachés à Auschwitz. Juif, déporté, chimiste, témoin, écrivain, retour sur cette personnalité complexe, sur son ascension vers ce qu’il a appelé le « rescapé professionnel », sur son œuvre. Sur ce que les mots « résistance », « engagement » ont signifié pour lui. 27 januari 1945. Zeventig jaar geleden wandelden de eerste soldaten van het Rode Leger Auschwitz binnen. Men zou kunnen zeggen dat het kamp toen werd ‘bevrijd’, hoewel Auschwitz, en geen enkel ander nazikamp, ooit een prioriteit vormden voor de Geallieerden. Primo Levi was een van de weinige overlevenden die zich wisten te verbergen en zo ontsnapten aan de gedwongen evacuaties. Jood, gedeporteerde, chemicus, getuige, schrijver: we blikken terug op deze complexe figuur, op zijn evolutie tot wat hij zelf een ‘professionele overlevende’ noemde, op zijn oeuvre. En op de betekenis die hij aan de woorden ‘verzet’ en ‘engagement’ gaf. 27 January 1945. Seventy years ago the first soldiers of the Red Army marched into Auschwitz. One might argue that the camp was “liberated” then, but the truth is that neither Auschwitz, nor any of the other Nazi camps, was ever a priority to the Allied Powers. Primo Levi was one of the few survivors who knew how to hide and escape the enforced evacuation of the camps. With this dossier, we want to cast light on the complex figure that Levi was: a Jew, a deportee, a chemists, a witness, and a writer. It sets out to study his oeuvre and his interpretation of the notions of “resistance” and “engagement”, in order to understand how he eventually became a “professional survivor”, as he once described himself