Occurrence of a cardiac heteroside in Bersama yangambiensis

SCOPUS: le.jFLWNAinfo:eu-repo/semantics/publishe

Comparison of the analgesic effects: Of p-cyclodextrin-piroxicam, sodium naproxen, and potassium diclofenac utilizing the dental pain model henri bauduin jean-pierre famaey

The nociceptive threshold of the six upper front teeth (left and right central and lateral incisors, and canines) of twelve volunteers was determined by an electrical stimulus delivered by a pulp tester. A single dose of 20 mg p-cyclodextrin-piroxicam, 50 mg potassium diclofenac or 275 mg sodium naproxen was given orally according to a double-blind randomized design with a one week interval between each drug. The nociceptive threshold was recorded every 15 min for 4 h. The analgesic profile was similar for the three drugs. Significant effect was observed after 30 minutes, peak action was reached between 45 and 60 minutes and lasted up to 120 minutes and disappearance of the effect below the level of significance after 150 minutes. The rapid onset of analgesia is consistent with the rapid absorption of these three drugs characterized with a short tmax of about 1 hour or less. The dental pain model explores essentially the central action of drugs on pain. It probably does not evaluate the effect of nonsteroidal antiinflammatory drugs on peripheral antiinflammatory and analgesic activities which account for their more protracted action in relevant clinical situations such as rheumatic, post-traumatic or post-surgical pain and inflammation. The central effect of these drugs on pain is of limited duration, [Article copies available from The Haworth Document Delivery Service: 1-800-342-9678,]. © 1995, Informa UK Ltd. All rights reserved.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

[Photographie de 4 poilus en pause : "Rassemblement au pinard : photographie / Bauduin, Henri]

Mentions manuscrites : nom des poilus présentsNumérisé par le partenaireAppartient à l’ensemble documentaire : GG14189GCAppartient à l’ensemble documentaire : GCGen1Numérisé par le partenair

Investigation on the metabolism of L leucine in the rat exocrine pancreas

SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe

Further chemical and pharmacological characterization of bersama yangambiensis toussaint (melianthaceae)

Bufadienolide glycoside was isolated and purified from Bersama yangambiensis. Partial characterization was accomplished by spectrometric data, and these data suggest that the bufadienolide is a new compound. Preliminary pharmacologic investigations confirmed the cardiotonic properties of this compound and showed an antitumor action in vitro. Copyright © 1972 Wiley‐Liss, Inc. A Wiley CompanySCOPUS: ar.jinfo:eu-repo/semantics/publishe

BREVE REVUE DU MODE D'ACTION DE LA STIMULATION ACUPUNCTURALE DANS SON EFFET ANALGESIQUE

SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Energy sources for protein synthesis and enzymatic secretion in rat pancreas in vitro

The main characteristics of rat pancreas energy metabolism in vitro have been established, and the relations between protein synthesis and this metabolism have been studied with the use of well-known inhibitors (oligomycin, antimycin, dinitrophenol, oxamate, fluoride, anaerobiosis). Krebs-Ringer Tris-HCl-buffered medium, supplemented with glucose and amino acid mixture, afforded the optimal conditions for incubation of rat pancreas pieces. Under these conditions a metabolic steady state was maintained for more than 2 h. Carbamylcholine and pancreozymine stimulated chymotrypsinogen and amylase secretion and oxygen uptake, and depressed leucine incorporation into proteins of the rat pancreatic pieces. Mitochondria supplied more than 90% of the energy of the pancreas; the ATP pool of the gland was renewed at least every 23 sec, and the respiratory control had a minimal value of 3.8. Glycolysis, which accounted for less than 10% of the energy output under normal conditions, supplied as much as 30% of control value in anaerobiosis. The effects of inhibitors of respiration and of glycolysis on amino acid incorporation into proteins suggest that protein synthesis depends on a common pool of ATP supplied by glycolysis and oxidative phosphorylation and that it is very sensitive to reduction of this pool. Oligomycin and oxamate did not inhibit the carbamylcholine-induced secretion, but anaerobiosis and the combination of oligomycin and oxamate did. These data suggest that stimulated secretion requires an ATP supply, if not an increase of the ATP generation. Strong reduction of ATP output by antimycin, oxamate with anaerobiosis or the combination of oligomycin and oxamate increased the spontaneous release of chymotrypsinogen, suggesting that retention of the enzymes in the cell is also dependent on a minimal energy supply. © 1969.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Non-dependence of secretion on protein synthesis

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Secretion and protein metabolism in the rat pancreas in vitro.

In VitroJournal Articleinfo:eu-repo/semantics/publishe

Role of cyclic 3′,5t́-AMP in the action of physiological secretagogues on the metabolism of rat pancreas in vitro

SCOPUS: ar.jinfo:eu-repo/semantics/publishe