Postseismic viscoelastic-gravitational half space computations: problems and solutions

We consider the problem of surface deformation arising from a fault in a semi-infinite, elastic-gravitational, and/or viscoelastic-gravitational, plane-layered medium, subject to an extemally imposed gravitational acceleration g. Rundle [1981, 1982] presented a calculation in which self-gravitation, represented by terms proportional to G are neglected, and the extemally imposed acceleration due to gravity, g, is considered constant in the medium. Because of the recent strong interest in cornputations of this type, we examine the assumptions involved in these computations. We show that these assumptions are not likely to have serious consequences in the relatively near-field viscoelastic displacements, where the earth's curvature is neglected. We also show that the approximation described by Rundle [1981, 1982], which was technically not regular as z → ∞, can easily be regularized using a new approach without appreciable change in the resulting displacement field.Peer reviewe

Study of heat transfer processes in the flowing part of hypersonic air-ramjet engine

The technique and results of the experimental-theoretical study of gas dynamics, heat transfer and the structure of gas flow in the flowing channel of a model hypersonic air-ramjet engine are presented for Mach numbers M (5; 6)

Identification and validation of potential new biomarkers for prostate cancer diagnosis and prognosis using 2D-DIGE and MS

This study was designed to identify and validate potential new biomarkers for prostate cancer and to distinguish patients with and without biochemical relapse. Prostate tissue samples analyzed by 2D-DIGE (two-dimensional difference in gel electrophoresis) and mass spectrometry (MS) revealed downregulation of secernin-1 (P < 0.044) in prostate cancer, while vinculin showed significant upregulation (P < 0.001). Secernin-1 overexpression in prostate tissue was validated using Western blot and immunohistochemistry while vinculin expression was validated using immunohistochemistry. These findings indicate that secernin-1 and vinculin are potential new tissue biomarkers for prostate cancer diagnosis and prognosis, respectively. For validation, protein levels in urine were also examined by Western blot analysis. Urinary vinculin levels in prostate cancer patients were significantly higher than in urine from nontumor patients (P = 0.006). Using multiple reaction monitoring-MS (MRM-MS) analysis, prostatic acid phosphatase (PAP) showed significant higher levels in the urine of prostate cancer patients compared to controls (P = 0.012), while galectin-3 showed significant lower levels in the urine of prostate cancer patients with biochemical relapse, compared to those without relapse (P = 0.017). Three proteins were successfully differentiated between patients with and without prostate cancer and patients with and without relapse by using MRM. Thus, this technique shows promise for implementation as a noninvasive clinical diagnostic technique

EuPACa: An Opportunity for EuPA to co-ordinate and promote Prostate Cancer Proteomics in Europe as part of Global Initiatives

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