Sensitivity Study for Improved Magnetic Induction Tomography (MIT) Coil System

Abstract-The improved magnetic induction tomography (MIT) coil system which consists of the two-arm Archimedean spiral coil (TAASC) as excitation coil and the solenoid as receiver coil has much better performance in coil system sensitivity than the conventional MIT coil system which uses the solenoids as excitation coil and receiver coil. In this paper the theoretical sensitivity property for improved MIT coil system are studied fully

Ecological Sensitivity Assessment and Spatial Pattern Analysis of Land Resources in Tumen River Basin, China

Ecological sensitivity is one of the important indicators of regional ecological fragility, which can represent the sensitivity of ecosystems to natural environmental conditions and human activity disturbances in the region. In this study, the ecological sensitivity of land resources in the Tumen River Basin of China was quantitatively evaluated by taking 3 ecologically sensitive impact types, including the natural environment, human disturbance, and soil erosion, as evaluation criteria, and 11 ecologically sensitive factors were selected to build an evaluation system using the analytic hierarchy process (AHP) method, to determine the weights of the evaluation factors, combined with geographic information system (GIS) technology. The results show that: (1) Among the three types of ecological sensitivity factors, the influence of human disturbance is the most obvious, and the two factors of land use type and distance from construction land have the highest weights in the comprehensive ecological sensitivity evaluation. (2) There are no extremely sensitive areas or insensitive areas in the Tumen River Basin in China. Highly sensitive areas account for only 0.59% of the total area and are mainly concentrated in the lakes, rivers, and reservoirs in the study area. Moderately sensitive areas account for 54.12%, which are concentrated in the central part of the Tumen River Basin Slightly sensitive areas are mainly located in the mountainous areas in the north and south of the study area. (3) Among the various land resource types, the proportion of slightly sensitive areas and moderately sensitive areas of woodland is close (about 50%), while cultivated land, grassland, construction land, and bare land are mainly moderately sensitive areas (73.95%, 82.07%, 96.59%, and 78.78%), and water bodies are mostly distributed within highly sensitive areas (60.97%), and all wetlands with the smallest area are moderately sensitive. The results of the study can provide data support and a scientific basis for regional ecological protection and development planning

Assessing the impacts of future urban expansion on multiple ecosystem services in the transnational area of Changbai Mountain

Introduction: An assessment of the potential impacts of future urban expansion on multiple ecosystem services (ESs) represents an essential contribution to the sustainable development of the transnational area of Changbai Mountain (TACM). However, the potential ES losses attributed to future urban expansion have been assessed in few studies.Methods: In this study, we evaluated the potential ES losses attributable to urban expansion in the TACM over the period from 2015 to 2050. To achieve this objective, we initially quantified multiple ESs (namely, food production (FP), carbon storage (CS), water retention (WR), and air purification (AP)) based on 1992 data, and subsequently simulated urban expansion from 2015 to 2050 by coupling Shared Socioeconomic Pathways scenarios (SSPs) with the zoned Land Use Scenario Dynamics-urban model. Finally, the potential impacts of future urban expansion on ESs were evaluated on multiple scales.Results: The results indicated that during the period from 2015 to 2050, the extent of urban land will grow by between 157.59 and 517.77 km2, resulting in FP, CS, WR, and AP losses of 193.76–684.39 thousand tons, 1.47–5.24 million tons, 8.74–30.00 million tons, and 0.34–1.18 thousand tons, respectively.Discussion: The subregion falling within the Democratic People’s Republic of Korea (DPRK) will experience the most severe future losses of ESs, with losses of FP, CS, WR, and AP being 1.06–3.77-fold, 1.15–3.46-fold, 1.10–3.54-fold, and 1.08–3.21-fold higher, respectively than those that occurred in this subregion the period of 1992–2015. Specifically, the encroachment of new urban land onto cropland and woodland will be the main contributing factor in these future declines in ESs. Furthermore, the reductions in ESs attributable to urban expansion in this subregion will have serious effects on human wellbeing. By 2050, the loss of FP will affect approximately 9.58%–30.00% of the population. Moreover, among the residents of this subregion, the loss of AP will contribute to the need for additional expenditures of 6.63–19.81 million euros on air purification measures. On the basis of these findings, we suggest that effective policies and regulations should be implemented to promote the sustainable development of the TACM

Dexamethasone ameliorates H₂S-induced acute lung injury by alleviating matrix metalloproteinase-2 and -9 expression.

Acute lung injury (ALI) is one of the fatal outcomes after exposure to high levels of hydrogen sulfide (H2S), and the matrix metalloproteinases (MMPs) especially MMP-2 and MMP-9 are believed to be involved in the development of ALI by degrading the extracellular matrix (ECM) of blood-air barrier. However, the roles of MMP-2 and MMP-9 in H2S-induced ALI and the mechanisms of dexamethasone (DXM) in treating ALI in clinical practice are still largely unknown. The present work was aimed to investigate the roles of MMP-2 and MMP-9 in H2S-induced ALI and the protective effects of DXM. In our study, SD rats were exposed to H2S to establish the ALI model and in parallel, A549 cells were incubated with NaHS (a H2S donor) to establish cell model. The lung HE staining, immunohistochemisty, electron microscope assay and wet/dry ratio were used to identify the ALI induced by H2S, then the MMP-2 and MMP-9 expression in both rats and A549 cells were detected. Our results revealed that MMP-2 and MMP-9 were obviously increased in both mRNA and protein level after H2S exposure, and they could be inhibited by MMP inhibitor doxycycline (DOX) in rat model. Moreover, DXM significantly ameliorated the symptoms of H2S-induced ALI including alveolar edema, infiltration of inflammatory cells and the protein leakage in BAFL via up-regulating glucocorticoid receptor(GR) to mediate the suppression of MMP-2 and MMP-9. Furthermore, the protective effects of DXM in vivo and vitro study could be partially blocked by co-treated with GR antagonist mifepristone (MIF). Our results, taken together, demonstrated that MMP-2 and MMP-9 were involved in the development of H2S-induced ALI and DXM exerted protective effects by alleviating the expression of MMP-2 and MMP-9. Therefore, MMP-2 and MMP-9 might represent novel pharmacological targets for the treatment of H2S and other hazard gases induced ALI

A novel, effective machine learning-based RNA editing profile for predicting the prognosis of lower-grade gliomas

Patients with low-grade glioma (LGG) may survive for long time periods, but their tumors often progress to higher-grade lesions. Currently, no cure for LGG is available. A-to-I RNA editing accounts for nearly 90% of all RNA editing events in humans and plays a role in tumorigenesis in various cancers. However, little is known regarding its prognostic role in LGG. On the basis of The Cancer Genome Atlas (TCGA) data, we used LASSO and univariate Cox regression to construct an RNA editing site signature. The results derived from the TCGA dataset were further validated with Gene Expression Omnibus (GEO) and Chinese Glioma Genome Atlas (CGGA) datasets. Five machine learning algorithms (Decision Trees C5.0, XGboost, GBDT, Lightgbm, and Catboost) were used to confirm the prognosis associated with the RNA editing site signature. Finally, we explored immune function, immunotherapy, and potential therapeutic agents in the high- and low-risk groups by using multiple biological prediction websites. A total of 22,739 RNA editing sites were identified, and a signature model consisting of four RNA editing sites (PRKCSH|chr19:11561032, DSEL|chr18:65174489, UGGT1|chr2:128952084, and SOD2|chr6:160101723) was established. Cox regression analysis indicated that the RNA editing signature was an independent prognostic factor, according to the ROC curve (AUC = 0.823), and the nomogram model had good predictive power (C-index = 0.824). In addition, the predictive ability of the RNA editing signature was confirmed with the machine learning model. The sensitivity of PCI-34051 and Elephantin was significantly higher in the high-risk group than the low-risk group, thus potentially providing a marker to predict the effects of lung cancer drug treatment. RNA editing may serve as a novel survival prediction tool, thus offering hope for developing editing-based therapeutic strategies to combat LGG progression. In addition, this tool may help optimize survival risk assessment and individualized care for patients with low-grade gliomas

Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population

Lead (Pb) is one of the major contaminants in many industries, and imposes hazardous effects on multiple human organs and systems. Studies have shown that lead is able to induce the alteration of microRNA (miRNA) expression in serum and organs. In this study we investigated whether polymorphisms in miRNA-regulating genes were associated with the risk of lead exposure. We genotyped seven single-nucleotide polymorphisms (SNPs) in 113 lead-sensitive and 113 lead-resistant lead-related Chinese workers by Taqman analysis. The lead-sensitive group showed a significantly higher blood lead level (BLL) than the resistant group based on unconditional logistic regression results. One SNP in XPO5 extron (rs2257082) was significantly associated with lead-poisoning (p = 0.022, odds rate (OR) = 1.63, 95% confidence interval (CI) = 1.07–2.47 in the C allele compared to the T allele). There were no significant associations between the other six SNPs and the blood lead levels. Therefore, polymorphism rs2257082 could be used to distinguish lead-resistant and lead-susceptible populations, and to develop more specific and accurate preventions

Notch polymorphisms associated with sensitivity of noise induced hearing loss among Chinese textile factory workers

Abstract Background Noise induced hearing loss (NIHL) is a polygenic disease involving both genetic and environmental factors, and is one of the most important occupational health hazards worldwide. To date, the influence of Notch1 variants on the risk to develop NIHL has not been illuminated. This study was conducted to explore the effects of Notch1 polymorphisms on individual susceptibility to NIHL. Methods A total of 2689 industrial workers from one textile factory in east China were recruited to participate in the current study. Venous blood was collected, basic clinical data was obtained by questionnaires and pure-tone audiometry (PTA) tests were conducted by specialist physicians. Next we performed genotyping of three selected SNPs (rs3124594, rs3124599 and rs3124603) in the Notch1 gene in 535 NIHL patients and 535 controls. Subsequently, the main effects of the genotypes and their interactions were evaluated. Results Our results revealed that individuals with a GG of rs3124594, TT of rs3124603 (OR = 4.70 and 1.59 respectively) and the haplotype AAC (rs3124594-rs3124599-rs3124603) (OR = 14.95) were associated with an increased risk of NIHL in our study cohort. Stratified analysis showed that an increased NIHL risk was found in individuals exposed to work related noise for ≤16 years that also had the rs3124594 GG or rs3124603 CT/TT genotype with an OR of 4.20 and 1.73 respectively. Multifactor dimensionality reduction analysis indicated that rs3124594, rs3124599 and rs3124603 interacted with each other and were related to an increased risk to develop NIHL (OR = 3.60). Conclusions The genetic polymorphisms rs3124594 and rs3124603 within the Notch1 gene are associated with an increased risk of NIHL in a Chinese population and could potentially be used as biomarkers for NIHL in noise exposed workers