30 research outputs found

    Nicotinamide and alpha-tocopherol combination partially protects t-butyl hydroperoxide-induced neurotoxicity: Implication for neurodegenerative disease

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    In light of evidences of impaired energy metabolism and oxidative damage in neurodegenerative disorders, we have investigated the potential role of compounds which may improve the mitochondrial metabolism and can ameliorate the toxic effects of free radicals, and thus compensate for disease-related defects. Treatments with three doses of t-butyl hydroperoxide (t-BuOOH) resulted in increased lipid peroxidation in corpus striatum. The superoxide dismutase (SOD, EC 1.15.1.1) activity increased while reduced gluthathione content reclined. Supplementation with alpha-tocopherol and nicotinamide and their combination resulted in decline in LPO and showed the tendency towards normalization of SOD activity and GSH content. The results showed that supplementation of a combination of alpha-tocopherol and nicotinamide provides protection against t-BuOOH-induced neurotoxicity
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