Pulsed ultrasound-modulated optical tomography using spectral hole-burning

We present a novel optical quantum sensor using spectral hole-burning for detecting signals in ultrasound-modulated optical tomography. In this technique, we utilize the capability of sub-MHz spectral filtering afforded by a spectral hole burning crystal to select the desired spectral component from the ultrasound-modulated diffuse light. This technique is capable of providing a large etendue, processing a large number of speckles in parallel, tolerating speckle decorrelation, and imaging in real-time. Experimental results are presented

High-sensitivity spin-based electrometry with an ensemble of nitrogen-vacancy centers in diamond

We demonstrate a spin-based, all-dielectric electrometer based on an ensemble of nitrogen-vacancy (NV[superscript −]) defects in diamond. An applied electric field causes energy-level shifts symmetrically away from the NV[superscript −]'s degenerate triplet states via the Stark effect; this symmetry provides immunity to temperature fluctuations allowing for shot-noise-limited detection. Using an ensemble of NV[superscript −]s, we demonstrate shot-noise-limited sensitivities approaching 1 (V/cm)/√Hz under ambient conditions, at low frequencies (<10 Hz), and over a large dynamic range (20 dB). A theoretical model for the ensemble of NV[superscript −]s fits well with measurements of the ground-state electric susceptibility parameter 〈k[subscript ⊥]〉. Implications of spin-based, dielectric sensors for micron-scale electric-field sensing are discussed.United States. National Aeronautics and Space Administration. Office of Chief Technologist (Space Technology Research Fellowship)United States. Air Force Office of Scientific Research. Presidential Early Career Award in Science and Engineerin

Quantum Optics and Photonics

Contains reports on nine research projects.National Science Foundation (Grant PHY82-10369)Joint Services Electronics Program (Contract DAAG29-83-K-0003)U.S. Air Force - Office of Scientific Research (Contract F49620-82-C-0091)Litton Guidance and Control SystemNational Science Foundation (Grant PHY82-10369

Pulsed ultrasound-modulated optical tomography using spectral hole-burning

We present a novel optical quantum sensor using spectral hole-burning for detecting signals in ultrasound-modulated optical tomography. In this technique, we utilize the capability of sub-MHz spectral filtering afforded by a spectral hole burning crystal to select the desired spectral component from the ultrasound-modulated diffuse light. This technique is capable of providing a large etendue, processing a large number of speckles in parallel, tolerating speckle decorrelation, and imaging in real-time. Experimental results are presented

Innovations in Surface Modification Techniques: Advancing Hydrophilic \textit{LiYF4_{4}:Yb, Er, Tm} Upconversion Nanoparticles and Their Applications

The development and application of upconversion nanoparticles (UCNPs) have garnered significant attention due to their unique optical properties and potential uses in bioimaging, drug delivery, and solar cells. However, the hydrophobic nature of UCNPs presents challenges in their synthesis and application, particularly in aqueous environments. We provide an overview of UCNPs, their synthesis challenges, and the importance of surface modification. Furthermore, we discuss the properties of \textit{LiYF_{4}:Yb, Er, Tm} UCNPs synthesized using novel 2,2-[ethylenebis(oxy)] bisacetic acid (EBAA) method and their versatile applications. Notably, the first Dynamic Light Scattering measurement on 05/22/2022 showed a size of 11.39 nm, and after 348 days on 04/05/2023, the same batch maintained a size of 13.8 nm, indicating excellent stability and no particle agglomeration over this extended period. This remarkable stability underscores the potential of UCNPs synthesized with the EBAA method for long-term applications. Finally, we compare the EBAA method with other surface modification techniques, exploring challenges and future perspectives for the use of hydrophilic UCNPs in various applications. This review aims to emphasize the significance of the EBAA method in advancing the field of upconversion nanoparticles and broadening their potential integration into diverse applications.Comment: 21 Pages, 1 table, 13 figure

Quantum Optics and Photonics

Contains reports on seven research projects.U.S. Air Force Geophysics Laboratory (Contract F19628-70-C-0082)Joint Services Electronics Program (Contract DAAG29-83-K-0003)National Science Foundation (Grant PHY82-10369)U.S. Air Force - Rome Air Development Center (in collaboration with C.C. Leiby, Jr.)U.S. Air Force - Rome Air Development Center (Contract F19628-80-C-0077)U.S. Air Force - Office of Scientific Research (Contract F49620-82-C-0091

Quantum Optics and Photonics

Contains reports on nine research projects.U.S. Air Force - Office of Scientific Research (Contract F49620-82-C-0091)Joint Services Electronics Program (Contract DAAG29-83-K-0003)National Science Foundation (Grant PHY82-10369)Litton Guidance and Control Syste

Development of a prediction model for recurrence in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

INTRODUCTION: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival outcomes for selected patients with colorectal peritoneal metastases (PM), but recurrence rates are high. The aim of this study was to develop a tool to predict recurrence in patients with colorectal PM that undergo CRS-HIPEC.MATERIALS AND METHODS: For this retrospective cohort study, data of patients that underwent CRS-HIPEC for colorectal PM from four Dutch HIPEC centers were used. Exclusion criteria were perioperative systemic therapy and peritoneal cancer index (PCI) ≥20. Nine previously identified factors were considered as predictors: gender, age, primary tumor characteristics (location, nodal stage, differentiation, and mutation status), synchronous liver metastases, preoperative Carcino-Embryonal Antigen (CEA), and peritoneal cancer index (PCI). The prediction model was developed using multivariable Cox regression and validated internally using bootstrapping. The performance of the model was evaluated by discrimination and calibration.RESULTS: In total, 408 patients were included. During the follow-up, recurrence of disease occurred in 318 patients (78%). Significant predictors of recurrence were PCI (HR 1.075, 95% CI 1.044-1.108) and primary tumor location (left sided HR 0.719, 95% CI 0.550-0.939). The prediction model for recurrence showed fair discrimination with a C-index of 0.64 (95% CI 0.62, 0.66) after internal validation. The model was well-calibrated with good agreement between the predicted and observed probabilities.CONCLUSION: We developed a prediction tool that could aid in the prediction of recurrence in patients with colorectal PM who undergo CRS-HIPEC.</p

Development of a prediction model for recurrence in patients with colorectal peritoneal metastases undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy

INTRODUCTION: Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) improves survival outcomes for selected patients with colorectal peritoneal metastases (PM), but recurrence rates are high. The aim of this study was to develop a tool to predict recurrence in patients with colorectal PM that undergo CRS-HIPEC.MATERIALS AND METHODS: For this retrospective cohort study, data of patients that underwent CRS-HIPEC for colorectal PM from four Dutch HIPEC centers were used. Exclusion criteria were perioperative systemic therapy and peritoneal cancer index (PCI) ≥20. Nine previously identified factors were considered as predictors: gender, age, primary tumor characteristics (location, nodal stage, differentiation, and mutation status), synchronous liver metastases, preoperative Carcino-Embryonal Antigen (CEA), and peritoneal cancer index (PCI). The prediction model was developed using multivariable Cox regression and validated internally using bootstrapping. The performance of the model was evaluated by discrimination and calibration.RESULTS: In total, 408 patients were included. During the follow-up, recurrence of disease occurred in 318 patients (78%). Significant predictors of recurrence were PCI (HR 1.075, 95% CI 1.044-1.108) and primary tumor location (left sided HR 0.719, 95% CI 0.550-0.939). The prediction model for recurrence showed fair discrimination with a C-index of 0.64 (95% CI 0.62, 0.66) after internal validation. The model was well-calibrated with good agreement between the predicted and observed probabilities.CONCLUSION: We developed a prediction tool that could aid in the prediction of recurrence in patients with colorectal PM who undergo CRS-HIPEC.</p

Quantum Electronics

Contains thirteen research projects split into three sections.U.S. Air Force - Rome Air Development Center (Contract F19628-80-C-0077)National Science Foundation (Grant PHY79-09739)Joint Services Electronics Program (Contract DAAG29-78-C-0020)Joint Services Electronics Program (Contract DAAG29-80-C-0104)U.S. Air Force Geophysics Laboratory (AFSC) (Contract F19628-79-C-0082)National Science Foundation (Grant ECS79-19475)National Science Foundation (Grant DAR80-08752)National Science Foundation (Grant ENG79-09980