9 research outputs found

    Synthesis of novel polyhydroxylated quinolizidines: Ring expanded analogs of glycosidase inhibitory indolizidines

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    Two polyhydroxylated quinolizidines, (1R,2R,3R,9S,9aR)-1,2,3,9-tetrahydroxyquinolizidine 9 and (1R,2R,3R,9R,9aS-1,2,3,9-tetrahydroxyquinolizidine 10, have been synthesized by the reductive double cyclization of 15[alpha] and 15[beta]. Quinolizidine 9 can be viewed either as a ring expanded analog of 6-epicastanospermine or of 8-episwainsonine, while 10 is a ring expanded analog of 1,6,8a-triepicastanospermine or of 8a-episwainsonine.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/30391/1/0000009.pd

    Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

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    This work was supported by a restricted research grant of Bayer AG
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