3,762 research outputs found
Nano-Pulse Stimulation for the Treatment of Pancreatic Cancer and the Changes in Immune Profile
A Pancreatic cancer is a notorious malignant neoplasm with an extremely poor prognosis. Current standard of care is rarely effective against late-stage pancreatic cancer. In this study, we assessed nanopulse stimulation (NPS) as a local treatment for pancreatic cancer in a syngeneic mouse Pan02 pancreatic cancer model and characterized corresponding changes in the immune profile. A single NPS treatment either achieved complete tumor regression or prolonged overall survival in animals with partial tumor regression. While this is very encouraging, we also explored if this local ablation effect could also result in immune stimulation, as was observed when NPS led to the induction of immune-mediated protection from a second tumor challenge in orthotopic mouse breast and rat liver cancer models. In the Pan02 model, there were insufficient abscopal effects (1/10) and vaccine-like protective effects (1/15) suggesting that NPS-induced immune mechanisms in this model were limited. To evaluate this further, the immune landscape was analyzed. The numbers of both T regulatory cells (Tregs) and myeloid derived suppressor cells (MDSCs) in blood were significantly reduced, but memory (CD44+) T-cells were absent. Furthermore, the numbers of Tregs and MDSCs did not reduce in spleens compared to tumor-bearing mice. Very few T-cells, but large numbers of MDSCs were present in the NPS treated tumor microenvironment (TME). The number of dendritic cells in the TME was increased and multiple activation markers were upregulated following NPS treatment. Overall, NPS treatments used here are effective for pancreatic tumor ablation, but require further optimization for induction of immunity or the need to include effective combinational NPS therapeutic strategy for pancreatic cancer
Inversionless gain in a three-level system driven by a strong field and collisions
Inversionless gain in a three-level system driven by a strong external field
and by collisions with a buffer gas is investigated. The mechanism of
populating of the upper laser level contributed by the collision transfer as
well as by relaxation caused by a buffer gas is discussed in detail. Explicit
formulae for analysis of optimal conditions are derived. The mechanism
developed here for the incoherent pump could be generalized to other systems.Comment: RevTeX, 9 pages, 4 eps figure
Structural correlations in heterogeneous electron transfer at monolayer and multilayer graphene electrodes
As a new form of carbon, graphene is attracting intense interest as an electrode material with widespread applications. In the present study, the heterogeneous electron transfer (ET) activity of graphene is investigated using scanning electrochemical cell microscopy (SECCM), which allows electrochemical currents to be mapped at high spatial resolution across a surface for correlation with the corresponding structure and properties of the graphene surface. We establish that the rate of heterogeneous ET at graphene increases systematically with the number of graphene layers, and show that the stacking in multilayers also has a subtle influence on ET kinetics. © 2012 American Chemical Society
Algebraic Model for scattering in three-s-cluster systems. I. Theoretical Background
A framework to calculate two-particle matrix elements for fully
antisymmetrized three-cluster configurations is presented. The theory is
developed for a scattering situation described in terms of the Algebraic Model.
This means that the nuclear many-particle state and its asymptotic behaviour
are expanded in terms of oscillator states of the intra-cluster coordinates.
The Generating Function technique is used to optimize the calculation of matrix
elements. In order to derive the dynamical equations, a multichannel version of
the Algebraic Model is presented.Comment: 20 pages, 1 postscript figure, submitted to Phys. Rev.
Vibrational Enhancement of the Effective Donor - Acceptor Coupling
The paper deals with a simple three sites model for charge transfer phenomena
in an one-dimensional donor (D) - bridge (B) - acceptor (A) system coupled with
vibrational dynamics of the B site. It is found that in a certain range of
parameters the vibrational coupling leads to an enhancement of the effective
donor - acceptor electronic coupling as a result of the formation of the
polaron on the B site. This enhancement of the charge transfer efficiency is
maximum at the resonance, where the effective energy of the fluctuating B site
coincides with the donor (acceptor) energy.Comment: 5 pages, 3 figure
The Fueling and Evolution of AGN: Internal and External Triggers
In this chapter, I review the fueling and evolution of active galactic nuclei
(AGN) under the influence of internal and external triggers, namely intrinsic
properties of host galaxies (morphological or Hubble type, color, presence of
bars and other non-axisymmetric features, etc) and external factors such as
environment and interactions. The most daunting challenge in fueling AGN is
arguably the angular momentum problem as even matter located at a radius of a
few hundred pc must lose more than 99.99 % of its specific angular momentum
before it is fit for consumption by a BH. I review mass accretion rates,
angular momentum requirements, the effectiveness of different fueling
mechanisms, and the growth and mass density of black BHs at different epochs. I
discuss connections between the nuclear and larger-scale properties of AGN,
both locally and at intermediate redshifts, outlining some recent results from
the GEMS and GOODS HST surveys.Comment: Invited Review Chapter to appear in LNP Volume on "AGN Physics on All
Scales", Chapter 6, in press. 40 pages, 12 figures. Typo in Eq 5 correcte
A dressed bag model study of the final-state interaction in photoproduction processes off the deuteron
The impact of the short-range interaction on the pion
photoproduction processes off the deuteron in the -resonance region is
studied in the framework of recently proposed dressed-bag model. A common
dressing procedure for bare three- and six-quark states is used to describe
both the pion decay widths of baryon resonances and the effective (or
) interaction at short ranges related to the inner dressed-bag
states. It is shown that the effect of short-range interaction for
the forward-angle photoproduction off the deuteron cannot be
neglected. The prospects for further development of the model to describe the
short-range (or ) correlations in the lightest nuclei are
discussed
Spin-orbit induced interference in quantum corrals
Lack of inversion symmetry at a metallic surface can lead to an observable
spin-orbit interaction. For certain metal surfaces, such as the Au(111)
surface, the experimentally observed spin-orbit coupling results in spin
rotation lengths on the order of tens of nanometers, which is the typical
length scale associated with quantum corral structures formed on metal
surfaces. In this work, multiple scattering theory is used to calculate the
local density of states (LDOS) of quantum corral structures comprised of
nonmagnetic adatoms in the presence of spin-orbit coupling. Contrary to
previous theoretical predictions, spin-orbit coupling induced modulations are
observed in the theoretical LDOS, which should be observable using scanning
tunneling microscopy.Comment: 7 pages, 3 figures, accepted to Nano Letter
Deconfining Phase Transition as a Matrix Model of Renormalized Polyakov Loops
We discuss how to extract renormalized from bare Polyakov loops in SU(N)
lattice gauge theories at nonzero temperature in four spacetime dimensions.
Single loops in an irreducible representation are multiplicatively renormalized
without mixing, through a renormalization constant which depends upon both
representation and temperature. The values of renormalized loops in the four
lowest representations of SU(3) were measured numerically on small, coarse
lattices. We find that in magnitude, condensates for the sextet and octet loops
are approximately the square of the triplet loop. This agrees with a large
expansion, where factorization implies that the expectation values of loops in
adjoint and higher representations are just powers of fundamental and
anti-fundamental loops. For three colors, numerically the corrections to the
large relations are greatest for the sextet loop, ; these
represent corrections of for N=3. The values of the renormalized
triplet loop can be described by an SU(3) matrix model, with an effective
action dominated by the triplet loop. In several ways, the deconfining phase
transition for N=3 appears to be like that in the matrix model of
Gross and Witten.Comment: 24 pages, 7 figures; v2, 27 pages, 12 figures, extended discussion
for clarity, results unchange
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