Effects of intravenous theophylline on exercise-induced myocardial ischemia: II. A concentration-dependent phenomenon

AbstractObjectives. The effects of varying concentrations of theophylline on exercise-induced myocardial ischemia were evaluated in patients with stable coronary artery disease.Background. Theophylline is a competitive antagonist of adenosine and may have potential as an anti-ischemic medication. It is not known whether these effects on myocardial ischemia are concentration dependent.Methods. In a double-blind, randomized, crossover manner, 11 patients received, at 1-week intervals, placebo and each of three theophylline doses by intravenous infusion for 45 min. Graded exercise testing was performed before randomization and immediately after each infusion. Concurrent anti-ischemic medications were withheld for 24 h before each exercise test. Serum theophylline concentrations achieved were 3.9 ± 1.0 mg/liter (low), 8.2 ± 1.8 mg/liter (medium) and 13.2 ± 2.3 mg/liter (high).Results. Compared with placebo, none of the three theophylline infusions produced a significant alteration in rest heart rate, blood pressure, mean frequency or severity of ventricular ectopic activity or noncardiac symptoms. The time to onset of ischemia was progressively increased, with medium and high concentrations achieving statistical significance. Similar patterns were observed for oxygen uptake and the heart rate-systolic blood pressure product at the onset of ischemia. Total exercise duration was significantly prolonged with the medium and high concentrations.Conclusions. It is concluded that administration of varying doses of theophylline before exercise produces a clinically significant and concentration-dependent improvement in the indicators of myocardial ischemia in patients with chronic stable coronary artery disease

Prospectus, April 14, 1975

CIA INFORMANT AT P.C.?; Angela Davis At PC; Pfaab Should Resign: McMullen; Biology Students Replant Trees As Part Of Park -land Master Plan; Next Prospectus\u27 New Column; The Kaleidoscope; Photography 35: A Focus on Lenses; The Short Circuit; Skylines; Special Feature: Earth Week 1975; Environmental Educators Hold Role Seminar; CU Observes Earth Week April, 12: Lincoln Square Exhibits, Individual Exhibits; Want To Know More?; How Many Clean Lungs At PC?; Grad Petitions; Instructors Participate; Deadline For Southwest Tour Is April 15; Walk For The Eagles; EPA Seminar On Pollution Held On Campus; Classified Ads; Sports Views; Sportscape; Vet\u27s Corner; Parkland Sports Car Club; Parkland Events; Arts And Crafts For The Aged; Meeting For All STU-GO Candidates Set For May 1; Spring Carnival Topic Of Meeting; Top Hot Fifteenhttps://spark.parkland.edu/prospectus_1975/1013/thumbnail.jp

Prospectus, April 28, 1975

SPRING CARNIVAL ACTIVITIES SET FOR MAY 1; Speech No. 1; StuGo Election May 7-8; PC News....In Brief: President\u27s Report, 11% Salary Hike Approved, Davis Confirmed As Security Head, Trustee\u27s Board Summary; editorials; opinion; The Short Circuit; The Kaleidoscope; letters; Photography 35: Tips On Using An Exposure Meter; \u27We want to please the people,\u27 Garrett; Skylines; The Hot Fifteen; Magic Bus Heads List Of Foreign Films; StuGo Minutes; L.T.D.s Corner; Wanted: Ace Reporters; Classified Ads; Boy Watching?; Lost In The Darkness; Sports Views; Girl\u27s Softball Starts 2-1 Season; Parkland Place At Kansas Relays; Art Exhibit To Be Held May 9th; The Parable, May 8 In C118; Girl\u27s Volleyball Tournament May 5; Parkland Events; Parkland Jazz Group Performs; Women\u27s Program Holds Film Fest; Theta Epsilon Fair May 5; Candian Canoe Trip Group To Me Meet Friday; Final Examination Schedule; Blood Donor Turnout \u27Fair\u27; Veterans Plan A Lake Of The Woods Cook-Out; Yoga To Meet At 11 Tuesday; Polish Sausage Sale To Be Held April 29https://spark.parkland.edu/prospectus_1975/1011/thumbnail.jp

Prospectus, April 7, 1975

SPEECH, DEBATE TO NATIONALS; Five Elected To PC\u27s Student Government; 82% Of Parents Surveyed Here Want Parkland Day Care Center; 25% Profit On Bookstore Buy Back Policy ; Marchetti Will Speak Tuesday On CIA Secrecy; Bicentennial Planned; editorials; letters; The Short Circuit; The Kaleidoscope; Skylines; Students Earn Spot On Winter Honors List; Eight Candidates For Parkland Board; Photography 35; Music Students To Make Own Instruments; The Top Hot Rock Hits Of The Week; Cats Were Not Always Vain; Earth Interview; Pendragon Enjoys Unique Music Style; To The Son Of God; Autumn Feeling; Classified Ads; L.T.D.\u27s Corner; Workshop On Instruction; Miss C Amvet Contest Set; PC Republicans To Meet Wednesday; Camera Buffs!; Loans For Vets; Heavy Scene At 404 East Green; Records Becoming Expensive To Buy; Cindy Nolin, David Wiechman Student Achievement Winners; Bland Wins Mayor; New Program; Summer Class To Tour The US Southwest; Knaus And Holaday Win Grain And Feed Assn. Scholarshiphttps://spark.parkland.edu/prospectus_1975/1014/thumbnail.jp

The pacing stress test: Thallium-201 myocardial imaging after atrial pacing. Diagnostic value in detecting coronary artery disease compared with exercise testing

Many patients suspected of having coronary artery disease are unable to undergo adequate exercise testing. An alternate stress, pacing tachycardia, has been shown to produce electrocardiographic changes that are as sensitive and specific as those observed during exercise testing. To compare thallium-201 imaging after atrial pacing stress with thallium imaging after exercise stress, 22 patients undergoing cardiac catheterization were studied with both standard exercise thallium imaging and pacing thallium imaging.Positive ischemic electrocardiographic changes (> 1 mm ST segment depression) were noted in 11 of 16 patients with coronary artery disease during exercise, and in 15 of the 16 patients during atrial pacing. One of six patients with normal or trivial coronary artery disease had a positive electrocardiogram with each test. Exercise thallium imaging was positive in 13 of 16 patients with coronary artery disease compared with 15 of 16 patients during atrial pacing. Three of six patients without coronary artery disease had a positive scan with exercise testing, and two of these same patients developed a positive scan with atrial pacing. Of those patients with coronary artery disease and an abnormal scan, 85% showed redistribution with exercise testing compared with 87% during atrial pacing. Segment by segment comparison of thallium imaging after either atrial pacing or exercise showed that there was a good correlation of the location and severity of the thallium defects (r = 0.83, p = 0.0001, Spearman rank correlation).It is concluded that the location and presence of both fixed and transient thallium defects after atrial pacing are closely correlated with the findings after exercise testing. Thus, atrial pacing may be used as a stress for myocardial perfusion scintigraphy in patients unable to complete a satisfactory exercise test

Prospectus, April 21, 1975

ORGANIZED STRUGGLE,\u27 DAVIS; Bomb Scare????; StuGo: Wegner Made Secretary Get Budget; Hot Meals; Albin, Barnes, Hood Win Trustee Election; StuGo Elections May 7-8; editorials; letters; The Short Circuit; The Kaleidoscope; Special Feature: Women In Art; Women Work Of Art; Who\u27s Afraid Of ERA??; The Poison Pen Tongue; Chess Talk; EIU At PC; Photography 35; L.T.D.s Corner: Pure Music: by Chase; Skylines; This And That; Sports Views; Cobras Drop Twin Bill; E. St. Louis Track Meet; Bio-Field Course; Walk For The Bald Eagles Week; Track To Kansas; Classified Ads; Moon Lake; Cat Ballou; L.R.C. Hires New Staff Member; Parkland Events; Suggestion Box; New PC Staffhttps://spark.parkland.edu/prospectus_1975/1012/thumbnail.jp