3 research outputs found
Philippi public transport interchange
Abstract To overcome limitations of diversity measures applied to livestock breeds marker based estimations of kinship within and between populations were proposed. This concept was extended from the single locus consideration to chromosomal segments of a given length in Morgan. Algorithms for the derivation of haplotype kinship were suggested and the behaviour of marker based haplotype kinship was investigated theoretically. In the present study the results of the first practical application of this concept are presented. Full sib pairs of three sub-populations of the Goettingen minipig were genotyped for six chromosome segments. After haplotype reconstruction the haplotypes were compared and mean haplotype kinships were estimated within and between populations. Based on haplotype kinships a distance measure is proposed which is approximatively linear with the number of generations since fission. The haplotype kinship distances, the respective standard errors and the pedigree-based expected values are presented and are shown to reflect the true population history better than distances based on single-locus kinships. However the marker estimated haplotype kinship reveals variable among segments. This leads to high standard errors of the respective distances. Possible reasons for this phenomenon are discussed and a pedigree-based approach to correct for identical haplotypes which are not identical by descent is proposed.</p
Haplotype kinship for three populations of the Goettingen minipig
To overcome limitations of diversity measures applied to livestock breeds
marker based estimations of kinship within and between populations were
proposed. This concept was extended from the single locus consideration to
chromosomal segments of a given length in Morgan. Algorithms for the
derivation of haplotype kinship were suggested and the behaviour of marker
based haplotype kinship was investigated theoretically. In the present study
the results of the first practical application of this concept are
presented. Full sib pairs of three sub-populations of the Goettingen minipig
were genotyped for six chromosome segments. After haplotype reconstruction
the haplotypes were compared and mean haplotype kinships were estimated
within and between populations. Based on haplotype kinships a distance
measure is proposed which is approximatively linear with the number of
generations since fission. The haplotype kinship distances, the respective
standard errors and the pedigree-based expected values are presented and are
shown to reflect the true population history better than distances based on
single-locus kinships. However the marker estimated haplotype kinship
reveals variable among segments. This leads to high standard errors of the
respective distances. Possible reasons for this phenomenon are discussed and
a pedigree-based approach to correct for identical haplotypes which are not
identical by descent is proposed