41 research outputs found
Effect of Anti-mu Antisera On Collagen Arthritis - Evidence That Antibody Is Required for the Induction of Disease
Propylthiouracil induced C-ANCA positive agranulocytosis complicating Gravesâ thyrotoxicosis in pregnancy
Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis
CD4+ T cells are central mediators of autoimmune pathology; however, the definition of their key effector functions in specific autoimmune diseases remains limited. Pathogenic CD4+ T cells within affected tissues may be identified by expression of markers of recent activation1. We applied this approach to joint tissue in rheumatoid arthritis (RA), a chronic immune7ediated arthritis that affects up to 1% of the population2. Utilizing mass cytometry to detect activated T cells in RA synovial tissue revealed a strikingly expanded population of PD-1hi CXCR5- CD4+ T cells. These cells are not exhausted, Rather, multidimensional cytometry, transcriptomics, and functional assays define a population of PD-1hi CXCR5- âperipheral helperâ T (Tph) cells that express factors enabling B cell help, including IL-21, CXCL13, ICOS, and MAF. Like PD-1hi CXCR5+ T âfollicular helperâ (Tfh) cells, Tph cells induce plasma cell differentiation in vitro via IL-21 and SLAMF5-interactions3,4. However, global transcriptomics robustly separate Tph cells from Tfh cells, with altered expression of Bcl6 and Blimp-1 and unique expression of chemokine receptors that direct migration to inflamed sites, such as CCR2, CX3CR1, and CCR5, in Tph cells. Tph cells appear uniquely poised to promote B cell responses and antibody production within pathologically inflamed non-lymphoid tissues