Biomechanical signaling within the developing zebrafish heart attunes endocardial growth to myocardial chamber dimensions

Intra-organ communication guides morphogenetic processes that are essential for an organ to carry out complex physiological functions. In the heart, the growth of the myocardium is tightly coupled to that of the endocardium, a specialized endothelial tissue that lines its interior. Several molecular pathways have been implicated in the communication between these tissues including secreted factors, components of the extracellular matrix, or proteins involved in cell-cell communication. Yet, it is unknown how the growth of the endocardium is coordinated with that of the myocardium. Here, we show that an increased expansion of the myocardial atrial chamber volume generates higher junctional forces within endocardial cells. This leads to biomechanical signaling involving VE-cadherin, triggering nuclear localization of the Hippo pathway transcriptional regulator Yap1 and endocardial proliferation. Our work suggests that the growth of the endocardium results from myocardial chamber volume expansion and ends when the tension on the tissue is relaxed

The Mark Of The Bonds Bank: Germany's Role in European Monetary Cooperation

With the bundesbank now a dominant german actor in international moneteryb cooperations, germany's partner states have begun to consider the requirement of the bank-rather than the goverment-as paramount

The mark of the bundesbank: Germany role in European monetary cooperation/ Heisenberg

ix, 194 hal.; 23 cm

The mark of the bundesbank: Germany role in European monetary cooperation/ Heisenberg

ix, 194 hal.; 23 cm

The mark of the bundesbank: Germany role in European monetary cooperation/ Heisenberg

ix, 194 hal.; 23 cm

The mark of the bundesbank: Germany role in European monetary cooperation/ Heisenberg

ix, 194 hal.; 23 cm

The mark of the bundesbank: Germany role in European monetary cooperation/ Heisenberg

ix, 194 hal.; 23 cm

The mark of the bundesbank: Germany role in European monetary cooperation/ Heisenberg

ix, 194 hal.; 23 cm