Osteonecrosis of the Maxilla and Mandible in Patients with Advanced Cancer Treated with Bisphosphonate Therapy

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139939/1/onco0911.pd

An Update on the Role of Interim Restaging FDG-PET in Patients With Diffuse Large B-Cell Lymphoma and Hodgkin Lymphoma

A significant amount of literature is available on treatment monitoring and response assessment in lymphoma using FDG-PET, yet confusion exists concerning the potential and limitations of FDG-PET for determining the presence of residual disease during chemotherapy (interim FDG-PET). This article reviews the role of interim FDG-PET in 3 important scenarios: untreated diffuse large B-cell lymphoma, untreated Hodgkin lymphoma, and relapsed or refractory aggressive lymphoma in transplant-eligible patients, and provides recommendations on the use of this imaging modality in these settings

Nuclear medicine operations in the times of COVID-19 : strategies, precautions, and experiences

The COVID-19 pandemic has now reached most countries and is straining health-care systems worldwide to their limits. Emergency room and intensive care staff are at increased risk for infection. Nobody knows the exact mortality rates associated with infections. However, given a likely very large number of infected patients, the number of fatalities will be high even if mortality rates are less than 1%. As recent events in Europe indicate, hospitals may simply be overwhelmed by the high number of patients needing care. Strategies to contain the spread of the virus are, therefore, essential. Outpatient hospital-based or free-standing imaging clinics are also exposed to asymptomatic carriers and patients with flulike symptoms. There are different ways to tackle this challenge, and this short article aims to provide you with an overview of different approaches supporting decision making. We briefly summarize strategies, precautions, and experiences from clinics in Europe (Fanti, Herrmann, Hacker, and Meyer), Australia (Hicks, Scott), Asia (Hatazawa, Yun), Africa (Sathekge), and the United States (Allen-Auerbach, Schoder) as implemented by local leadership.http://jnm.snmjournals.orgam2020Nuclear Medicin

TUMOR METABOLISM AND PERFUSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA: PRETREATMENT MULTIMODALITY IMAGING WITH H-1 MAGNETIC RESONANCE SPECTROSCOPY, DYNAMIC CONTRAST-ENHANCED MRI, AND [F-18]FDG-PET

PURPOSE: To correlate proton magnetic resonance spectroscopy ((1)H-MRS), dynamic contrast-enhanced MRI (DCE-MRI) and (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) in nodal metastases of patients with head and neck squamous cell carcinoma (HNSCC) for assessment of tumor biology. Additionally, pretreatment multimodality imaging (MMI) was evaluated for its efficacy in predicting short-term response to treatment. METHODS AND MATERIALS: Metastatic neck nodes were imaged with (1)H-MRS, DCE-MRI and (18)F-FDG PET in 16 patients with newly diagnosed HNSCC before treatment. Short-term radiological response was evaluated at 3–4 months. The correlations between (1)H-MRS (choline concentration, Cho/W), DCE-MRI (volume transfer constant, K(trans); volume fraction of the extravascular extracellular space, v(e); and redistribution rate constant, k(ep)) and (18)F-FDG PET (standard uptake value, SUV; and total lesion glycolysis, TLG) were calculated using non-parametric Spearman rank correlation. To predict the short-term response, logistic regression analysis was performed. RESULTS: A significant positive correlation was found between Cho/W and TLG (ρ = 0.599, p = 0.031). Cho/W correlated negatively with heterogeneity measures std(v(e)) (ρ = −0.691, p = 0.004) and std(k(ep)) (ρ = −0.704, p = 0.003). SUVmax values correlated strongly with MRI tumor volume (ρ = 0.643, p = 0.007). Logistic regression indicated that std(K(trans)) and SUVmean were significant predictors of short-term response (p < 0.07). CONCLUSION: Pretreatment multi-modality imaging using (1)H-MRS, DCE-MRI and (18)F-FDG PET is feasible in HNSCC patients with nodal metastases. Additionally, combined DCE-MRI and (18)F-FDG PET parameters were predictive of short-term response to treatment