2,003 research outputs found
Non-linear rheology of active particle suspensions: Insights from an analytical approach
We consider active suspensions in the isotropic phase subjected to a shear
flow. Using a set of extended hydrodynamic equations we derive a variety of
{\em analytical} expressions for rheological quantities such as shear viscosity
and normal stress differences. In agreement to full-blown numerical
calculations and experiments we find a shear thickening or -thinning behaviour
depending on whether the particles are contractile or extensile. Moreover, our
analytical approach predicts that the normal stress differences can change
their sign in contrast to passive suspensions.Comment: 11 pages, 10 figures, appear in PR
Structure and Strength of Dislocation Junctions: An Atomic Level Analysis
The quasicontinuum method is used to simulate three-dimensional
Lomer-Cottrell junctions both in the absence and in the presence of an applied
stress. The simulations show that this type of junction is destroyed by an
unzipping mechanism in which the dislocations that form the junction are
gradually pulled apart along the junction segment. The calculated critical
stress needed for breaking the junction is comparable to that predicted by line
tension models. The simulations also demonstrate a strong influence of the
initial dislocation line directions on the breaking mechanism, an effect that
is neglected in the macroscopic treatment of the hardening effect of junctions.Comment: 4 pages, 3 figure
Anti-de Sitter Supersymmetry
We give a pedagogical introduction to certain aspects of supersymmetric field
theories in anti-de Sitter space. Among them are the presence of masslike terms
in massless wave equations, irreducible unitary representations and the
phenomenon of multiplet shortening.Comment: Lectures presented by B. de Wit at the Winter School of Theoretical
Physics, Polanica, Poland, February 1999. 23 pp., LateX file, requires
packages latexsym, amsfonts, cl2emult.cl
Fatigue Equivalent Stress State Approach Validation in Non-conservative Criteria: a Comparative Study
Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21
Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of childhood precursor B-cell acute lymphoblastic leukemia. There are no cell lines with iAMP21 and these abnormalities are too complex to faithfully engineer in animal models. As a resource for future functional and pre-clinical studies, we have created xenografts from intrachromosomal amplification of chromosome 21 leukemia patient blasts and characterised them by in-vivo and ex-vivo luminescent imaging, FLOW immunophenotyping, and histological and ultrastructural analysis of bone marrow and the central nervous system. Investigation of up to three generations of xenografts revealed phenotypic evolution, branching genomic architecture and, compared with other B-cell acute lymphoblastic leukemia genetic subtypes, greater clonal diversity of leukemia initiating cells. In support of intrachromosomal amplification of chromosome 21 as a primary genetic abnormality, it was always retained through generations of xenografts, although we also observed the first example of structural evolution of this rearrangement. Clonal segregation in xenografts revealed convergent evolution of different secondary genomic abnormalities implicating several known tumour suppressor genes and a region, containing the B-cell adaptor, PIK3AP1, and nuclear receptor co-repressor, LCOR, in the progression of B-ALL. Tracking of mutations in patients and derived xenografts provided evidence for co-operation between abnormalities activating the RAS pathway in B-ALL and for their aggressive clonal expansion in the xeno-environment. Bi-allelic loss of the CDKN2A/B locus was recurrently maintained or emergent in xenografts and also strongly selected as RNA sequencing demonstrated a complete absence of reads for genes associated with the deletions
Measurement of the electron electric dipole moment using GdIG
A new method for the detection of the electron edm using a solid is
described. The method involves the measurement of a voltage induced across the
solid by the alignment of the samples magnetic dipoles in an applied magnetic
field, H. A first application of the method to GdIG has resulted in a limit on
the electron edm of 5E-24 e-cm, which is a factor of 40 below the limit
obtained from the only previous solid-state edm experiment. The result is
limited by the imperfect discrimination of an unexpectedly large voltage that
is even upon the reversal of the sample magnetization.Comment: 10 pages, 5 figures, v2:references corrected, submitted to PRL,
v3:added labels to figure
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