3 research outputs found
Euglycemic Diabetic Ketoacidosis Due to SGLT2 Inhibitor in a Patient with Gitelman Syndrome: A Therapeutic Dilemma
Euglycemic diabetic ketoacidosis (DKA) is a rarely reported side effect of sodium-glucose cotransporter-2 inhibitor (SGLT2i) empagliflozin. A 51-year-old female with Gitelman syndrome and type 2 diabetes mellitus (DM) presented with abdominal pain after a recent hospitalization for acute pancreatitis. Her diabetes medications included metformin, pioglitazone, and empagliflozin. Diabetic ketoacidosis was suspected; however, glucose levels were below the cutoff for DKA; therefore, she was diagnosed with euglycemic DKA. Her pancreatitis workup was insignificant. Severe symptomatic hypokalemia despite aggressive repletion limited the management of DKA with insulin infusion therapy. As her ketonemia resolved, she was initiated on subcutaneous insulin with a small but acceptable decrease in potassium. The therapeutic dilemma of managing euglycemic DKA due to SGLT2i in a patient with Gitelman syndrome has not been previously described
Online Estimation and Optimization of Utility-Based Shortfall Risk
Utility-Based Shortfall Risk (UBSR) is a risk metric that is increasingly
popular in financial applications, owing to certain desirable properties that
it enjoys. We consider the problem of estimating UBSR in a recursive setting,
where samples from the underlying loss distribution are available
one-at-a-time. We cast the UBSR estimation problem as a root finding problem,
and propose stochastic approximation-based estimations schemes. We derive
non-asymptotic bounds on the estimation error in the number of samples. We also
consider the problem of UBSR optimization within a parameterized class of
random variables. We propose a stochastic gradient descent based algorithm for
UBSR optimization, and derive non-asymptotic bounds on its convergence
Pregabalin-Induced Myopathy in a Double Lung Transplant Recipient
Pregabalin is a gamma-aminobutyric acid (GABA) derivative that was commercially approved by the Food and Drug Administration (FDA) in 2004. It is commonly used in the treatment of diabetic neuropathy, peripheral neuropathy, and spinal cord injury. We present the case of a 36-year-old Caucasian male double lung transplant recipient who presented with an 18-month history of fatigue and muscle weakness. He had elevated creatinine kinase level and his muscle biopsy showed evidence of drug-induced myopathy that improved after the cessation of pregabalin. We present a case of drug-induced myopathy as a rare complication of pregabalin therapy in a double lung transplant recipient