4,331 research outputs found
Eliminating the Performance Anomaly of 802.11b
Abstract. In this paper, we propose a mechanism to eliminate the per-formance anomaly of IEEE 802.11b. Performance anomaly happens when nodes that have different transmission rates are in the same wireless cell. All the nodes in the cell might experience the same throughput even though their transmission rates are different because DCF of WLAN provides equal probability of channel access, but it does not guarantee the equal utilization of the wireless channel among the nodes. To reduce such a performance anomaly, we adjust the frame size proportionally depending on the bit rate. Additionally, our scheme eliminates the per-formance anomaly in multi-hop case. Simulation study shows that our scheme achieves an improvement in the aggregate throughput and the fairness.
Susceptibility to Oxidative Stress is Greater in Korean Patients with Coronary Artery Disease than Healthy Subjects
There are some evidences that the increased oxidative stress and thus increased oxidizability of lipoproteins and DNA can contribute to the development of certain human diseases, such as cardiovascular disease. To confirm the association of DNA damage with cardiovascular disease, we investigated susceptibility of DNA to oxidation in lymphocytes and oxidative stress related parameters in blood of patients with coronary artery disease (CAD). Subjects were consisted of 42 patients (27 men, 15 women) with documented CAD and 49 apparently healthy subjects (33 men, 16 women) as controls. Cellular DNA damage induced by 100 ”M H2O2 was measured using Comet assay and quantified by TL. There were no differences in age (61.4 ± 1.7 years vs 62.0 ± 2.2 years) between the two groups. All the findings were shown to be independent of either sex or smoking habit. The patients showed significantly higher TL (87.3 ± 1.6 ”m) compared to the control (79.3 ± 1.7 ”m, p<0.01). Plasma TRAP, vitamin C, γ-tocopherol, and α-carotene levels in patients group were lower than those of control groups, while erythrocytic catalase activity increased in patients group. In conclusion, we observed that reduced overall antioxidant status was closely connected to higher susceptibility of DNA damage in CAD patients
Chronic intermittent form of isovaleric aciduria in a 2-year-old boy
Isovaleric aciduria (IVA) is caused by an autosomal recessive deficiency of isovaleryl-CoA dehydrogenase (IVD). IVA presents either in the neonatal period as an acute episode of fulminant metabolic acidosis, which may lead to coma or death, or later as a "chronic intermittent form" that is associated with developmental delays, with or without recurrent acidotic episodes during periods of stress, such as infections. Here, we report the case of a 2-year old boy with IVA who presented with the chronic intermittent form. He was admitted to Asan Medical Center Children's Hospital with recurrent vomiting. Metabolic acidosis, hyperammonemia, elevated serum lactate and isovalerylcarnitine levels, and markedly increased urine isovalerylglycine concentration were noted. Sequence analysis of the IVD gene in the patient revealed the novel compound mutations-a missense mutation, c.986T>C (p.Met329Thr) and a frameshift mutation, c.1083del (p.Ile361fs*11). Following stabilization during the acute phase, the patient has remained in a stable condition on a low-leucine diet
Kaempferol inhibits ILâ1ÎČâinduced proliferation of rheumatoid arthritis synovial fibroblasts and the production of COXâ2, PGE2 and MMPs
Inflammatory cytokines, matrix metalloproteinases (MMPs) and cyclooxygenase (COX)â2 released from rheumatoid arthritis synovial fibroblasts (RASFs) are involved in the destruction of both articular bone and cartilage. Kaempferol has been reported to act as an antioxidant and antiâinflammatory agent by inhibiting nitric oxide synthase and COX enzymes. The aim of the present study was to determine the effects of kaempferol on the interleukinâ1ÎČ (ILâ1ÎČ)âinduced proliferation of RASFs and the production of MMPs, COX and prostaglandin E2 (PGE2) by RASFs. The proliferation of the RASFs stimulated with ILâ1ÎČ and treated with/without kaempferol was evaluated by CCKâ8 assay. The expression of MMPs, TIMP metallopeptidase inhibitorâ1 (TIMPâ1), COXs, PGE2 and that of intracellular MAPK signaling molecules, including pâERK, pâp38, pâJNK and nuclear factorâÎșB (NFâÎșB) was examined by immunoblotting or semiâquantitative reverse transcriptionâpolymerase chain reaction (RTâPCR) and ELISA under the conditions described above. Kaempferol inhibited the proliferation of both unstimulated and ILâ1ÎČâstimulated RASFs, as well as the mRNA and protein expression of MMPâ1, MMP-3, COXâ2 and PGE2 induced by ILâ1ÎČ. Kaempferol also inhibited the phosphorylation of ERKâ1/2, p38 and JNK, as well as the activation of NFâÎșB induced by ILâ1ÎČ. These results indicate that kaempferol inhibits synovial fibroblast proliferation, as well as the production of and MMPs, COXâ2 and PGE2, which is involved in articular inflammation and destruction in rheumatoid arthritis (RA). Our data suggest that kaempferol may be a novel therapeutic agent for the treatment of RA
Associations between maternal stress during pregnancy and offspring internalizing and externalizing problems in childhood
BACKGROUND: Maternal psychological health during pregnancy has been associated with offspring psychopathology. However, it is uncertain whether these associations are mediated by the postpartum depression and related child-rearing factors. Therefore, we examined the associations between prenatal and postnatal factors and internalizing and externalizing behavioral problems in childhood, focusing on maternal psychological health in school-aged children in Korea. FINDINGS: The current study included 1,003 children (580 boys, 423 girls, mean age 9.05â±â0.70 years, age range 8â11 years) recruited from schools in five Korean cities. Childrenâs internalizing and externalizing problems were assessed by the Child Behavior Checklist (CBCL). The parents of the children completed structured questionnaires on perinatal factors. Among 1,003 children, 44 had internalizing problems (IP) and 30 had externalizing problems (EP). When comparing children with IP (nâ=â44) and without IP (nâ=â959), severe maternal stress during pregnancy (OR3.36, 95% CI 1.80-6.25) and postpartum depression (OR3.19, 95% CI 1.36-7.53) showed a significant association with the IP. When comparing children with EP (nâ=â30) and without EP (nâ=â973), low family income (OR2.19, 95% CI 1.05-4.56), unwanted pregnancy (OR2.76, 95% CI 1.28-5.95) and severe maternal stress during pregnancy (OR2.69, 95% CI 1.29-5.61) with the EP. Only maternal stress during pregnancy was significantly associated with the IP after controlling for postpartum depression and with the EP after controlling for family income and unwanted pregnancy. CONCLUSION: This study suggests the importance of maternal psychological health during perinatal period on childrenâs mental health. Further prospective studies in a larger sample are required to confirm our findings
- âŠ