Gestión de almacenes para mejorar la productividad en una empresa comercializadora de productos de limpieza, Lima 2021

El presente trabajo de investigación, tuvo como objetivo mejorar la productividad en una empresa comercializadora de productos de limpieza. El estudio es de tipo aplicada, con diseño experimental y cuantitativo. Para realizar las mejoras se ha utilizado tres herramientas: 5´s, ABC y Estandarización de trabajo. Como resultado se logró mejorar la exactitud de inventario de 85% a 96%, lo cual representan un incremento del 11%. En cuanto al costo de unidad almacenado, se redujo de S/.1.95 a S/.1.71 y esta reducción es de S/.0.24. Respecto a los costos logísticos de venta, se redujo de 3.60 % a 3.20%, lo cual representa un 0.40% de reducción y finalmente, se tuvo un incremento de la productividad del 62% a 85%, logrando mejorar en un 12%. Para finalizar, se realizó un análisis del flujo de caja, donde se ha obtenido indicadores de rentabilidad del proyecto, en la misma se logra una Tasa Interna de Retorno del 73% y un Valor Actual Neto de S/. 41,188.11 lo cual demuestra que el proyecto es viable. También, el índice de retorno es de S/.3.5, lo que quiere decir que por cada sol invertido se gana S/. 2.5.This research work aims to improve productivity in a company that markets cleaning products. The applied type studies, with experimental and quantitative design. To carry out the improvements, three tools have been used: 5's, ABC and Work Standardization. As a result, inventory accuracy was improved from 85% to 96%, which is an increase of 11%. Regarding the stored unit cost, it is reduced from S / .1.95 to S / .1.71 and this reduction is S / .0.24. Regarding the logistics cost of sales, it is reduced from 3.60% to 3.20%, which represents a reduction of 0.40% and finally, if I have an increase in productivity from 62% to 85%, achieving an improvement of 12%. Finally, a cash flow analysis was carried out, from which the project's profitability indicators were obtained, in which an Internal Rate of Return of 73% and a Net Current Value of S /. 41,188.11 place that demonstrates that the project is viable. In addition, the return index is S /. 3.5, so you must decide that for each sun invested you earn S /. 2.5

Aplicación de la herramienta ABC en la optimización de inventarios en las empresas productoras, un estudio de la revisión sistemática

El objetivo de este trabajo es conocer los beneficios y las limitaciones del método ABC y su aplicación en la gestión de inventarios, en empresas del rubro de limpieza en los últimos 10 años. En el artículo, se revisaron estudios precedentes de las siguientes bases de datos: google académico, Renati, Scielo, EBSCO y Proquest, tomando en cuenta los años de publicación (2009 a 2019). Las palabras claves que se emplearon para la búsqueda y recopilación correspondiente de los artículos fueron: “Optimización de inventarios”, “herramientas de almacenamientos”, “mejora de inventarios”, “método ABC”. Seguidamente, se logró ubicar 550 artículos, luego de un análisis bajo criterios de inclusión y exclusión se redujo a 30 artículos. Esta revisión sistemática se divide en cuatro partes. La primera, plantea de manera introductoria la urgencia de abordar los conceptos de gestión de inventarios y almacenamiento. La segunda parte, evidencia la metodológica aplicada en la recopilación de documentos académicos relevantes para la revisión propuesta. La tercera parte, exhibe los resultados obtenidos, para luego ser discutidos a detalle. Finalmente, enlista las conclusiones derivadas del apartado anterior

C-cell hyperplasia in thyroid tissue adjacent to follicular cell tumors

An immunohistochemical study was conducted on the number and distribution of C-cells in the nonneoplastic thyroid tissue adjacent to tumors of follicular cell origin. It consisted of 49 cases, of which 25 were papillary carcinomas, 22 were follicular adenomas, and 2 were follicular carcinomas. Twenty normal adult thyroids from the Broward's Medical Examiner's morgue served as controls. In 17 of the 49 cases (34.6%), there was a statistically significant increase in the number of C-cells in the normal-appearing thyroid tissue adjacent to follicular cell tumors, with at least 50 C-cells in one low power field, while only one of 20 normal thyroids had a similar number of cells. ( P=.02; χ 2=5.05). In two tumor cases these were more than 100 C-cells in several low power fields with formation of small C-cell nodules similar to those described in the type II Multiple Endocrine Neoplasia Syndrome (MEN). It was concluded that the nonneoplastic thyroid tissue adjacent to 34.6% of tumors with follicular cell phenotypes contains significantly more C-cells than those present in normal adult thyroids. The possible pathogenesis and clinical significance of these findings are discussed

Spinal Cord Tumors Presenting with Neural Tube Defects

Abstract Two primary lumbosacral tumors arising at the site of neural tube defects are presented. One was a teratoma diagnosed in an infant with myelomeningocele. The other was an ependymoma that developed in an adult with meningocele. It is postulated that these cases represent a neoplastic transformation of heterotopic primordial elements that have been incorporated within the defect, supporting the view that overgrowth of neural tissue may be the result rather than the cause of neural tube deformity. Such rare occurrences may be due to interaction between intrauterine teratogenic factors and familial predisposition in affected patients

Surgical management of perineal masses in patients with anorectal malformations

The aim of this study was to review the outcome of surgical management of various types of perineal masses encountered in patients with anorectal malformations (ARM). Retrospective review from 2 large pediatric anorectal referral centers. Twenty-two patients with a perineal mass were identified in more than 2000 patients treated for an ARM over a 15-year period. The 22 patients (4 men) represented all levels of severity of ARMs. The lesions were of 3 types: lipomas (n = 10), vascular anomalies (n = 4), and hamartomas/ choristomas (n = 8). The lipomas were carefully removed from between the muscle fibers during the posterior sagittal anorectoplasty. The vascular anomalies (3 of 4 were hemangiomas) underwent magnetic resonance imaging preoperatively, but none were found to invade deeply and all were excised at the time of the posterior sagittal anorectoplasty. The hamartomas/choristomas all occurred in women, and 50% arose as a pedunculated mass from the vulva. The lesions contained tissues such as glia, osteoid, nephrogenic rests, and endocervical-type mucosa. One was initially misinterpreted as a teratoma, prompting a wider excision. This and all subsequent patients have been correctly diagnosed pathologically as having either hamartomas or choristomas, which were not widely excised. Follow-up ranges from 5 months to 12 years. Six of the 10 lipoma patients are continent. One vascular anomaly was re-excised and there was minor wound separation in another. None of the hamartoma/choristoma lesions recurred. The presence of unusual perineal masses can add to the complexity of ARMs; however, most of these lesions can be carefully excised with preservation of the muscle complex and ultimate continence. Hamartomatous lesions can be mistaken for teratomas but do not require aggressive excision with clear margins. © 2005 Elsevier Inc. All rights reserved

Taller De Aptitud Vocacional Para Arquitectura-AR206-201601

El Taller de Aptitud Vocacional para Arquitectura es un curso de especialidad en la carrera de Arquitectura de carácter teórico-práctico dirigido a los estudiantes del ciclo 0 que no aprobaron la "Prueba de aptitud Vocacional para Arquitectura"; el curso permite verificar si el perfil de los estudiantes coincide con el necesario para el seguimiento de la Carrera de Arquitectura y busca desarrollar la competencia general de Manejo de la información y la competencia específica de Proyecto Arquitectónico. En este sentido el curso brinda el primer acercamiento a los conceptos arquitectónicos básicos y a la historia del arte y arquitectura con el fin de corroborar y/o reforzar las aptitudes vocacionales para la carrera de Arquitectura y así el estudiante aumente sus probabilidades de un buen desempeño académico y la exitosa culminación de la carrera

An epigenetic clock for gestational age based on human umbilical vein endothelial cells from a diverse population of newborns

Background: Epigenetic clocks are emerging as a useful tool in many areas of research. Many epigenetic clocks have been developed for adults; however, there are fewer clocks focused on newborns and most are trained using blood from European ancestry populations. In this study, we built an epigenetic clock based on primary human umbilical vein endothelial cells from a racially and ethnically diverse population. Results: Using human umbilical vein endothelial cell [HUVEC]-derived DNA, we calculated epigenetic gestational age using 83 CpG sites selected through elastic net regression. In this study with newborns from different racial/ethnic identities, epigenetic gestational age and clinical gestational age were more highly correlated (r = 0.85), than epigenetic clocks built from adult and other pediatric populations. The correlation was also higher than clocks based on blood samples from newborns with European ancestry. We also found that birth weight was positively associated with epigenetic gestational age acceleration (EGAA), while NICU admission was associated with lower EGAA. Newborns self-identified as Hispanic or non-Hispanic Black had lower EGAA than self-identified as non-Hispanic White. Conclusions: Epigenetic gestational age can be used to estimate clinical gestational age and may help index neonatal development. Caution should be exercised when using epigenetic clocks built from adults with children, especially newborns. We highlight the importance of cell type-specific epigenetic clocks and general pan tissue epigenetic clocks derived from a large racially and ethnically diverse population

Potential prognostic determinants for FET::CREB fusion-positive intracranial mesenchymal tumor

Abstract Intracranial mesenchymal tumor (IMT), FET::CREB fusion-positive is a provisional tumor type in the 2021 WHO classification of central nervous system tumors with limited information available. Herein, we describe five new IMT cases from four females and one male with three harboring an EWSR1::CREM fusion and two featuring an EWSR1::ATF1 fusion. Uniform manifold approximation and projection of DNA methylation array data placed two cases to the methylation class “IMT, subclass B”, one to “meningioma-benign” and one to “meningioma-intermediate”. A literature review identified 74 cases of IMTs (current five cases included) with a median age of 23 years (range 4–79 years) and a slight female predominance (female/male ratio = 1.55). Among the confirmed fusions, 25 (33.8%) featured an EWSR1::ATF1 fusion, 24 (32.4%) EWSR1::CREB1, 23 (31.1%) EWSR1::CREM, one (1.4%) FUS::CREM, and one (1.4%) EWSR1::CREB3L3. Among 66 patients with follow-up information available (median: 17 months; range: 1–158 months), 26 (39.4%) experienced progression/recurrences (median 10.5 months; range 0–120 months). Ultimately, three patients died of disease, all of whom underwent a subtotal resection for an EWSR1::ATF1 fusion-positive tumor. Outcome analysis revealed subtotal resection as an independent factor associated with a significantly shorter progression free survival (PFS; median: 12 months) compared with gross total resection (median: 60 months; p < 0.001). A younger age (< 14 years) was associated with a shorter PFS (median: 9 months) compared with an older age (median: 49 months; p < 0.05). Infratentorial location was associated with a shorter overall survival compared with supratentorial (p < 0.05). In addition, the EWSR1::ATF1 fusion appeared to be associated with a shorter overall survival compared with the other fusions (p < 0.05). In conclusion, IMT is a locally aggressive tumor with a high recurrence rate. Potential risk factors include subtotal resection, younger age, infratentorial location, and possibly EWSR1::ATF1 fusion. Larger case series are needed to better define prognostic determinants in these tumors