La casa de la edificación en Dax, Francia

This house has two storeys. The lower one includes an ample entrance hall, a reception room, the president's office, and the secretariat's offices. The upper floor has a resting room and the lecture hall. The highly competent design and correct choice and use of materials, with their natural texture and colours, make this small and singular building highly attractive.Se ha organizado en dos plantas de altura. La baja consta de: amplio hall de entrada, sala de recepción, despacho del presidente y oficinas de la secretaría; la planta superior contiene: la sala de descanso y la de conferencias. Su acertado diseño y la adecuada selección y utilización de los materiales empleados, dejados con su textura y colores naturales, imprimen un agradable atractivo a este pequeño y cuidado edificio singular

Direct Thrombin Inhibitor Prevents Delayed Graft Function in a Porcine Model of Renal Transplantation

Chantier qualité GABackground. Kidney transplantations from donors after cardiac arrest (DCA) are characterized by an increase in the occurrence of delayed graft function and primary nonfunction. In this study, Melagatran, a selective reversible direct thrombin inhibitor was used to limit renal injury in a DCA pig kidney transplantation model. Methods. We used a porcine model of DCA to study the effects of treatment with Melagatran in the peri-conservation period. Thromboelastography was used to check Melagatran antithrombin effect on in vitro clot formation. Reverse-transcriptase polymerase chain reaction was used to analyze the peripheral immune cells activation status. Renal function and morphologic study were performed at days 1 and 7. Finally, we analyzed the mechanisms of Melagatran protection on kidney microvasculature primary endothelial cells. Results. Prolongation of coagulation time (Ex-Tem) was observed 10 min after injection; however, Melagatran did not modulate increases of thrombin-antithrombin complexes following reperfusion. Melagatran significant treatment lowered the proinflammatory status of circulating immune cells. Animal's survival was increased in Melagatran-treated groups (9 of 10 in Melagatran groups vs. 4 of 10 in controls at day 7). Renal injury and inflammation were also significantly reduced in treated groups. We also demonstrated a direct protective effect of Melagatran against endothelial cell activation and inflammation in vitro. Conclusion. Direct thrombin inhibitor administration in the periconservation period improved graft outcome and reduced renal injury in a model of DCA