Complex and regional-specific changes in the morphological complexity of GFAP+ astrocytes in middle-aged mice.

During aging, alterations in astrocyte phenotype occur in areas associated with age-related cognitive decline, including hippocampus. Previous work also reported subregion-specific changes in surface, volume and soma size of hippocampal astrocytes during physiological aging. Herein we extensively analyzed, by morphometric analysis, fine morphological features of GFAP+ astrocytes in young (6-month-old) and middle-aged (14-month-old) male mice. We observed remarkable heterogeneity in the astrocytic response to aging in distinct subfields and along the dorso-ventral axis of the hippocampus and in the entorhinal cortex (EC). Specifically, in middle-aged mice dorsal granule cell and molecular layers, but not dorsal hilus, astrocytes underwent remarkable increase in their morphological complexity. These changes were absent in ventral Dentate Gyrus (vDG). In addition, in EC, the major input to dorsal DG (dDG), astrocytes underwent remarkable atrophic changes in middle-aged mice. Since dDG, and not vDG, is involved in cognitive functions, these findings appear worth of further evaluation. Our findings also suggest an additional level of complexity in the structural changes associated with brain aging

Salmeterol, a \u3b22 Adrenergic Agonist, Promotes Adult Hippocampal Neurogenesis in a Region-Specific Manner.

Neurogenesis persists in the subgranular zone of the hippocampal formation in the adult mammalian brain. In this area, neural progenitor cells (NPCs) receive both permissive and instructive signals, including neurotransmitters, that allow them to generate adult-born neurons which can be functionally integrated in the preexisting circuit. Deregulation of adult hippocampal neurogenesis (ahNG) occurs in several neuropsychiatric and neurodegenerative diseases, including major depression, and represents a potential therapeutic target. Of interest, several studies suggested that, both in rodents and in humans, ahNG is increased by chronic administration of classical monoaminergic antidepressant drugs, suggesting that modulation of this process may participate to their therapeutic effects. Since the established observation that noradrenergic innervations from locus coeruleus make contact with NPC in the dentate gyrus, we investigated the role of beta adrenergic receptor (\u3b2-AR) on ahNG both in vitro and in vivo. Here we report that, in vitro, activation of \u3b22-AR by norepinephrine and \u3b22-AR agonists promotes the formation of NPC-derived mature neurons, without affecting NPC survival or differentiation toward glial lineages. Additionally, we show that a selective \u3b22-AR agonist able to cross the blood-brain barrier, salmeterol, positively modulates hippocampal neuroplasticity when chronically administered in adult na\uefve mice. Indeed, salmeterol significantly increased number, maturation, and dendritic complexity of DCX+ neuroblasts. The increased number of DCX+ cells was not accompanied by a parallel increase in the percentage of BrdU+/DCX+ cells suggesting a potential prosurvival effect of the drug on neuroblasts. More importantly, compared to vehicle, salmeterol promoted ahNG, as demonstrated by an increase in the actual number of BrdU+/NeuN+ cells and in the percentage of BrdU+/NeuN+ cells over the total number of newly generated cells. Interestingly, salmeterol proneurogenic effects were restricted to the ventral hippocampus, an area related to emotional behavior and mood regulation. Since salmeterol is commonly used for asthma therapy in the clinical setting, its novel pharmacological property deserves to be further exploited with a particular focus on drug potential to counteract stress-induced deregulation of ahNG and depressive-like behavior

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives

Demonstratives in discourse

This volume explores the use of demonstratives in the structuring and management of discourse, and their role as engagement expressions, from a crosslinguistic perspective. It seeks to establish which types of discourse-related functions are commonly encoded by demonstratives, beyond the well-established reference-tracking and deictic uses, and also investigates which members of demonstrative paradigms typically take on certain functions. Moreover, it looks at the roles of non-deictic demonstratives, that is, members of the paradigm which are dedicated e.g. to contrastive, recognitional, or anaphoric functions and do not express deictic distinctions. Several of the studies also focus on manner demonstratives, which have been little studied from a crosslinguistic perspective. The volume thus broadens the scope of investigation of demonstratives to look at how their core functions interact with a wider range of discourse functions in a number of different languages. The volume covers languages from a range of geographical locations and language families, including Cushitic and Mande languages in Africa, Oceanic and Papuan languages in the Pacific region, Algonquian and Guaykuruan in the Americas, and Germanic, Slavic and Finno-Ugric languages in the Eurasian region. It also includes two papers taking a broader typological approach to specific discourse functions of demonstratives