A decade of DNA-hybrid catalysis: from innovation to comprehension

crosscheck: This document is CrossCheck deposited identifier: Michael Smietana (ORCID) identifier: Stellios Arseniyadis (ORCID) identifier: Stellios Arseniyadis (ResearcherID) copyright_licence: The Royal Society of Chemistry has an exclusive publication licence for this journal history: Received 22 January 2017; Accepted 23 April 2017; Accepted Manuscript published 25 April 2017; Advance Article published 9 May 2017We would like to thank the Agence Nationale de la Recherche for funding – the NCiS project (ANR-2010-JCJC-715-1) and the D-CYSIV project (ANR-2015-CE29-0021-01

Assessment of healthcare delivery in the early management of bacterial meningitis in UK young infants: an observational study.

OBJECTIVE: To define early presenting features of bacterial meningitis in young infants in England and to review the adequacy of individual case management as compared with relevant national guidelines and an expert panel review. DESIGN: Retrospective medical case note review and parental recall using standardised questionnaires. SETTING: England and Wales. PARTICIPANTS: Infants aged <90 days with bacterial meningitis diagnosed between July 2010 and July 2013. RESULTS: Of the 97 cases recruited across England and Wales, 66 (68%) were admitted from home and 31 (32%) were in hospital prior to disease onset. Almost all symptoms reported by parents appeared at the onset of the illness, with very few new symptoms appearing subsequently. Overall, 20/66 (30%) infants were assessed to have received inappropriate prehospital management. The median time from onset of first symptoms to first help was 5 hours (IQR: 2-12) and from triage to receipt of first antibiotic dose was 2.0 hours (IQR: 1.0-3.3), significantly shorter in infants with fever or seizures at presentation compared with those without (1.7 (IQR: 1.0-3.0) vs 4.2 (IQR: 1.8-6.3) hours, p=0.02). Overall, 26 (39%) infants had a poor outcome in terms of death or neurological complication; seizures at presentation was the only significant independent risk factor (OR, 7.9; 95% CI 2.3 to 207.0). For cases in hospital already, the median time from onset to first dose of antibiotics was 2.6 (IQR: 1.3-9.8) hours, and 12/31 (39%) of infants had serious neurological sequelae at hospital discharge. Hearing test was not performed in 23% and when performed delayed by ≥4 weeks in 41%. CONCLUSIONS: In young infants, the non-specific features associated with bacterial meningitis appear to show no progression from onset to admission, whereas there were small but significant differences in the proportion of infants with more specific symptoms at hospital admission compared with at the onset of the illness, highlighting the difficulties in early recognition by parents and healthcare professionals alike. A substantial proportion of infants received inappropriate prehospital and posthospital management. We propose a targeted campaign for education and harmonisation of practice with evidence-based management algorithms

Can a galaxy redshift survey measure dark energy clustering?

(abridged) A wide-field galaxy redshift survey allows one to probe galaxy clustering at largest spatial scales, which carries an invaluable information on horizon-scale physics complementarily to the cosmic microwave background (CMB). Assuming the planned survey consisting of z~1 and z~3 surveys with areas of 2000 and 300 square degrees, respectively, we study the prospects for probing dark energy clustering from the measured galaxy power spectrum, assuming the dynamical properties of dark energy are specified in terms of the equation of state and the effective sound speed c_e in the context of an adiabatic cold dark matter dominated model. The dark energy clustering adds a power to the galaxy power spectrum amplitude at spatial scales greater than the sound horizon, and the enhancement is sensitive to redshift evolution of the net dark energy density, i.e. the equation of state. We find that the galaxy survey, when combined with Planck, can distinguish dark energy clustering from a smooth dark energy model such as the quintessence model (c_e=1), when c_e<0.04 (0.02) in the case of the constant equation of state w_0=-0.9 (-0.95). An ultimate full-sky survey of z~1 galaxies allows the detection when c_e<0.08 (0.04) for w_0=0.9 (-0.95). We also investigate a degeneracy between the dark energy clustering and the non-relativistic neutrinos implied from the neutrino oscillation experiments, because the two effects both induce a scale-dependent modification in the galaxy power spectrum shape at largest spatial scales accessible from the galaxy survey. It is shown that a wider redshift coverage can efficiently separate the two effects by utilizing the different redshift dependences, where dark energy clustering is apparent only at low redshifts z<1.Comment: 14 pages, 7 figures; minor changes to match the published versio

Quadratic BSDEs driven by a continuous martingale and application to utility maximization problem

In this paper, we study a class of quadratic Backward Stochastic Differential Equations (BSDEs) which arises naturally when studying the problem of utility maximization with portfolio constraints. We first establish existence and uniqueness results for such BSDEs and then, we give an application to the utility maximization problem. Three cases of utility functions will be discussed: the exponential, power and logarithmic ones

Smart casual: Towards excellence in sessional teaching in law

The Smart Casual project was designed to create and disseminate resources to address a demonstrated national need for discipline-specific professional development for sessional law teachers. Sessional staff deliver half of Australian tertiary teaching. The quality of that teaching is crucial to student learning, retention and progress. Yet national research, as well as a needs analysis conducted as part of the Smart Casual seed project, suggests that support and training for sessional teachers remain inadequate. Law confronts specific barriers in responding to this challenge. Discipline-specific skills and content form substantial components of law curricula, which must meet nationally mandated threshold learning outcomes and professional admission requirements. Sessional law teachers are often time-poor legal practitioners or postgraduate researchers who bring vital experience, commitment to quality teaching and professional networks to the students they teach and the law schools in which they work. However, many are only weakly connected to the tertiary sector, and levels of teaching experience and teaching qualifications vary widely. This distinctive context demands discipline-specific sessional staff training, but our needs analysis shows that individual law schools lack the expertise and capacity to provide discipline-specific professional development

Integrated Joule switches for the control of current dynamics in parallel superconducting strips

Understanding and harnessing the physics of the dynamic current distribution in parallel superconducting strips holds the key to creating next generation sensors for single molecule and single photon detection. Non-uniformity in the current distribution in parallel superconducting strips leads to low detection efficiency and unstable operation, preventing the scale up to large area sensors. Recent studies indicate that non-uniform current distributions occurring in parallel strips can be understood and modeled in the framework of the generalized London model. Here we build on this important physical insight, investigating an innovative design with integrated superconducting-to-resistive Joule switches to break the superconducting loops between the strips and thus control the current dynamics. Employing precision low temperature nano-optical techniques, we map the uniformity of the current distribution before- and after the resistive strip switching event, confirming the effectiveness of our design. These results provide important insights for the development of next generation large area superconducting strip-based sensors

Rapid Cytotoxic T Lymphocyte Activation Occurs in the Draining Lymph Nodes After Cutaneous Herpes Simplex Virus Infection as a Result of Early Antigen Presentation and Not the Presence of Virus

Localized cutaneous herpes simplex virus type 1 (HSV-1) infection leads to arming and initial expansion of cytotoxic T lymphocytes (CTLs) in the draining popliteal lymph nodes (PLNs) followed by migration and further proliferation in the spleen. To accurately characterize the sequence of events involved in the activation and generation of anti-HSV CTLs, we used T cell receptor (TCR) transgenic mice specific for the immunodominant epitope from HSV glycoprotein B (gB498–505). We describe the detection of the initiation of antigen presentation in the draining lymph nodes by 4–6 h after infection with HSV-1. Analysis of CD69 up-regulation revealed activation of gB-specific CD8+ T cells by 6–8 h after infection. Furthermore, we show that T cell proliferation begins no sooner than 24 h after activation and is marked by the concurrent appearance of CTL activity in the PLNs. These events are not dependent on the presence of virus in the draining lymph nodes, and suggest a requirement for recruitment of professional antigen-presenting cells to the site of T cell activation. Consequently, we have defined the initiation of the CD8+ T cell–mediated response to cutaneous HSV-1 infection, demonstrating that the immune response to localized viral infection depends only on the appearance of cells presenting virus-derived antigen and commences with remarkable swiftness

’Team GB’ and London 2012: The Paradox of National and Global Identities

This article explores the problems associated with ’national identity’ in the UK and examines the tensions arising between the international and local dimensions of the games through examples of domestic (UK) and international (Brazil, Chicago) media coverage of the key debates relating to London’s period of preparation. The chapter proposes a conception of London 2012 as exemplar of an event poised to generate insights and experiences connected to a new politics of ’cosmopolitan’ identity; insights central to grasping the cultural politics of contemporary urban development-and the paradoxes of national identity in current discourses of Olympism. Properly speaking, cosmopolitanism suits those people who have no country, while internationalism should be the state of mind of those who love their country above all, who seek to draw to it the friendship of foreigners by professing for the countries of those foreigners an intelligent and enlightened sympathy. © 2010 Taylor & Francis