14 research outputs found
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Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates
Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5′-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation.The authors would like to thank the Wellcome Trust (grant number 094252/Z/10/Z) for funding this research. LM was supported by an EPSRC PhD studentship
Recommended from our members
Dissecting how modular polyketide synthase ketoreductases interact with acyl carrier protein-attached substrates
Interaction studies using fragments excised from the modular mycolactone polyketide synthase show that ketoreductase domains possess a generic binding site for acyl carrier protein domains and provide evidence that the pendant 5’-phosphopantetheine prosthetic group plays a key role in delivering acyl substrates to the active site in the correct orientation.The authors would like to thank the Wellcome Trust (grant number 094252/Z/10/Z) for funding this research. LM was supported by an EPSRC PhD studentship
Examination on Philosophy-Based Management of Contemporary Japanese Corporations: Philosophy, Value Orientation and Performance
corporate management philosophy, corporate value orientation, corporate performance,
Bullying in the U.S. Workplace: Normative and Process-Oriented Ethical Approaches
A-B-C-model, human resource management, legal, moral principles, workplace bullying,