Objective measurement of cough frequency during COPD exacerbation convalescence

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Cough and sputum production are associated with adverse outcomes in COPD and are common during COPD exacerbation (AE-COPD). This study of objective cough monitoring using the Hull Automated Cough Counter and Leicester Cough Monitor software confirms that this system has the ability to detect a significant decrease in cough frequency during AE-COPD convalescence. The ability to detect clinically meaningful change indicates a potential role in home monitoring of COPD patients

A Check-list of the Land Mammals of the Tanganyika territory and the Zanzibar protectorate

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Continuous cough monitoring using ambient sound recording during convalescence from a COPD exacerbation

Purpose Cough is common in chronic obstructive pulmonary disease (COPD) and is associated with frequent exacerbations and increased mortality. Cough increases during acute exacerbations (AE-COPD), representing a possible metric of clinical deterioration. Conventional cough monitors accurately report cough counts over short time periods. We describe a novel monitoring system which we used to record cough continuously for up to 45 days during AE-COPD convalescence. Methods This is a longitudinal, observational study of cough monitoring in AE-COPD patients discharged from a single teaching-hospital. Ambient sound was recorded from two sites in the domestic environment and analysed using novel cough classifier software. For comparison, the validated hybrid HACC/LCM cough monitoring system was used on days 1, 5, 20 and 45. Patients were asked to record symptoms daily using diaries. Results Cough monitoring data were available for 16 subjects with a total of 568 monitored days. Daily cough count fell significantly from mean±SEM 272.7±54.5 on day 1 to 110.9±26.3 on day 9 (p<0.01) before plateauing. The absolute cough count detected by the continuous monitoring system was significantly lower than detected by the hybrid HACC/LCM system but normalised counts strongly correlated (r=0.88, p<0.01) demonstrating an ability to detect trends. Objective cough count and subjective cough scores modestly correlated (r=0.46). Conclusions Cough frequency declines significantly following AE-COPD and the reducing trend can be detected using continuous ambient sound recording and novel cough classifier software. Objective measurement of cough frequency has the potential to enhance our ability to monitor the clinical state in patients with COPD

Metagenomic study of the viruses of African straw-coloured fruit bats: detection of a chiropteran poxvirus and isolation of a novel adenovirus

Viral emergence as a result of zoonotic transmission constitutes a continuous public health threat. Emerging viruses such as SARS coronavirus, hantaviruses and henipaviruses have wildlife reservoirs. Characterising the viruses of candidate reservoir species in geographical hot spots for viral emergence is a sensible approach to develop tools to predict, prevent, or contain emergence events. Here, we explore the viruses of Eidolon helvum, an Old World fruit bat species widely distributed in Africa that lives in close proximity to humans. We identified a great abundance and diversity of novel herpes and papillomaviruses, described the isolation of a novel adenovirus, and detected, for the first time, sequences of a chiropteran poxvirus closely related with Molluscum contagiosum. In sum, E. helvum display a wide variety of mammalian viruses, some of them genetically similar to known human pathogens, highlighting the possibility of zoonotic transmission

Lipid laden macrophages in respiratory disease

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Optimization of Naval propulsion machinery

This thesis document was issued under the authority of another institution, not NPS. At the time it was written, a copy was added to the NPS Library Collection for reasons not now known. It has been included in the digital archive for its historical value to NPS. Not believed to be a CIVINS (Civilian Institutions) title.The optimum naval propulsion plant is considered to be the one with the least total weight of machinery plus fuel. Perturbations of a modern destroyer propulsion cycle, with standard equipment components, are considered. Boiler pressure, condenser pressure , low pressure turbine exhaust annulus area, condenser surface, and leaving loss are considered variable. Equations are derived which express the variations in weight of important components. Availability balance methods are .applied in order to relate component efficiencies to fuel weight. Theoretical and numerical proof is given that leaving loss can be optimized on the basis of minimum turbine and condenser weight, independent of the rest of the cycle. This reduces the computations necessary in "brute force" analysis by an order of magnitude . As an example of the method, an availability balance is made for DLG-6 at cruising condition. Using 1050 F steam, boiler pressures from 800 psia to 1600 psia, and a broad range of condenser-L.P. turbine combinations, best parameters are found for ranges of 3*000, 5 $000, 7^000, and 10,000 miles „ Optimum condenser pressure is found to be fairly constant at 1.35" Hg. Abs., for the cruising condition and 75 F cooling water. The example studied indicates that standardization of naval propulsion plants at 1200 psia is on the high side of the optimum.http://www.archive.org/details/optimizationofna00hay

Permutable entire functions satisfying algebraic differential equations

It is shown that if two transcendental entire functions permute, and if one of them satisfies an algebraic differential equation, then so does the other one.Comment: 5 page

How to address health misinformation? Using focus groups to understand the experience and needs of Interprofessional undergraduate health professionals

The Problem of Health Misinformation Students from six different health professions share ideashttps://knowledgeconnection.mainehealth.org/lambrew-retreat-2023/1020/thumbnail.jp

Meromorphic traveling wave solutions of the complex cubic-quintic Ginzburg-Landau equation

We look for singlevalued solutions of the squared modulus M of the traveling wave reduction of the complex cubic-quintic Ginzburg-Landau equation. Using Clunie's lemma, we first prove that any meromorphic solution M is necessarily elliptic or degenerate elliptic. We then give the two canonical decompositions of the new elliptic solution recently obtained by the subequation method.Comment: 14 pages, no figure, to appear, Acta Applicandae Mathematica