The Hamburg/ESO R-process Enhanced Star survey (HERES) IV. Detailed abundance analysis and age dating of the strongly r-process enhanced stars CS 29491-069 and HE 1219-0312

We report on a detailed abundance analysis of two strongly r-process enhanced, very metal-poor stars newly discovered in the HERES project, CS 29491-069 ([Fe/H]=-2.51, [r/Fe]=+1.1) and HE 1219-0312 ([Fe/H]=-2.96, [r/Fe]=+1.5). The analysis is based on high-quality VLT/UVES spectra and MARCS model atmospheres. We detect lines of 15 heavy elements in the spectrum of CS 29491-069, and 18 in HE 1219-0312; in both cases including the Th II 4019 {\AA} line. The heavy-element abundance patterns of these two stars are mostly well-matched to scaled solar residual abundances not formed by the s-process. We also compare the observed pattern with recent high-entropy wind (HEW) calculations, which assume core-collapse supernovae of massive stars as the astrophysical environment for the r-process, and find good agreement for most lanthanides. The abundance ratios of the lighter elements strontium, yttrium, and zirconium, which are presumably not formed by the main r-process, are reproduced well by the model. Radioactive dating for CS 29491-069 with the observed thorium and rare-earth element abundance pairs results in an average age of 9.5 Gyr, when based on solar r-process residuals, and 17.6 Gyr, when using HEW model predictions. Chronometry seems to fail in the case of HE 1219-0312, resulting in a negative age due to its high thorium abundance. HE 1219-0312 could therefore exhibit an overabundance of the heaviest elements, which is sometimes called an "actinide boost"

Commensurability and beyond: from Mises and Neurath to the future of the socialist calculation debate

Mises' 'calculation argument' against socialism argues that monetary calculation is indispensable as a commensurable unit for evaluating factors of production. This is not due to his conception of rationality being purely 'algorithmic,' for it accommodates non-monetary, incommensurable values. Commensurability is needed, rather, as an aid in the face of economic complexity. The socialist Neurath's response to Mises is unsatisfactory in rejecting the need to explore possible non-market techniques for achieving a certain degree of commensurability. Yet Neurath's contribution is valuable in emphasizing the need for a balanced, comparative approach to the question of market versus non-market that puts the commensurability question in context. These central issues raised by adversaries in the early socialist calculation debate have continued relevance for the contemporary discussion

The Failure of ECB Monetary Policy from a Mises-Hayek Perspective

The paper analyses the common European monetary policy based on a Mises-Hayek overinvestment framework, which is combined with the theory of optimum currency areas. It shows how since the turn of the millennium a too expansionary monetary policy contributed to unsustainable overinvestment booms in the periphery of the European Monetary Union, and more recently in Germany, dependent on the national fiscal policy stances. It is argued that the ECB´s ultra-loose monetary policy as a crisis therapy puts a drag on long-term growth by conserving distorted economic structures. To preserve political stability a timely exit from the ultra-expansionary monetary policy is postulated

Persistent Unresolved Inflammation in the Mecp2-308 Female Mutated Mouse Model of Rett Syndrome

Rett syndrome (RTT) is a rare neurodevelopmental disorder usually caused by mutations in the X-linked gene methyl-CpG-binding protein 2 (MECP2). Several Mecp2 mutant mouse lines have been developed recapitulating part of the clinical features. In particular, Mecp2-308 female heterozygous mice, bearing a truncating mutation, are a validated model of the disease. While recent data suggest a role for inflammation in RTT, little information on the inflammatory status in murine models of the disease is available. Here, we investigated the inflammatory status by proteomic 2-DE/MALDI-ToF/ToF analyses in symptomatic Mecp2-308 female mice. Ten differentially expressed proteins were evidenced in the Mecp2-308 mutated plasma proteome. In particular, 5 positive acute-phase response (APR) proteins increased (i.e., kininogen-1, alpha-fetoprotein, mannose-binding protein C, alpha-1-antitrypsin, and alpha-2-macroglobulin), and 3 negative APR reactants were decreased (i.e., serotransferrin, albumin, and apolipoprotein A1). CD5 antigen-like and vitamin D-binding protein, two proteins strictly related to inflammation, were also changed. These results indicate for the first time a persistent unresolved inflammation of unknown origin in the Mecp2-308 mouse model

statistics biomedicine and scientific fraud

A consistent fraction of published data on scientific journals is not reproducible mainly due to insufficient knowledge of statistical methods. Here, we discuss on the use of proper statistical tools in biomedical research and statistical pitfalls potentially undermining the scientific validity of published data. Apart from unaware errors, a growing concern exists regarding data fabrication and scientific misconduct. Indeed, the social impact of false scientific data can be largely unpredictable and devastating, as shown by the worldwide dramatic effects on vaccinations coverage following a retracted paper published on a highly authoritative medical journal. Unfortunately, statistics shows a quite limited power in detecting false science, although a few statistical tools, such as the Benford's law, are known. Taken together, statistics in biomedical sciences i) is a powerful tool to interpret experimental data; ii) has limited power in detecting false science; and iii) first and foremost, is not the result of a simple "click of a mouse", but should be the result of accurate research planning by experienced and knowledgeable users

Two views on neutral money: Wieser and Hayek versus Menger and Mises

Neutral money plays a central role in contemporary macroeconomic theory, and is a live issue in recent monetary policy discussions. We challenge the opinion that Hayek’s writings on neutral money have been influenced by, and are similar to, the work of Menger and Mises. We show, first, the significant alternative influence of Friedrich von Wieser on Hayek’s work on the subject. Second, we rehabilitate a neglected method of monetary theorizing specific to Menger and Mises that rejects money neutrality both as a tool for investigating monetary phenomena and as the standard by which monetary regimes, and the market economy itself, should be evaluated. Examining this chapter in the history of economic thought can aid in a deeper reconsideration of the doctrinal foundations of modern monetary theory and policy

Grading hampers cooperative information sharing in group problem solving

We hypothesized that individual grading in group work, a widespread practice, hampers information sharing in cooperative problem solving. Experiment 1 showed that a condition in which members' individual contribution was expected to be visible and graded, as in most graded work, led to less pooling of relevant, unshared information and more pooling of less-relevant, shared information than two control conditions where individual contribution was not graded, but either visible or not. Experiment 2 conceptually replicated this effect: Group members primed with grades pooled less of their unshared information, but more of their shared information, compared to group members primed with neutral concepts. Thus, grading can hinder cooperative work and impair information sharing in groups.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Framing the neoliberal canon: resisting the market myth via literary enquiry

here is widespread recognition that neoliberal rhetoric about ‘free markets’ stands in considerable tension with ‘really existing’ neoliberalizing processes. However, the oft-utilized analytical distinction between ‘pure’ economic and political theory and ‘messy’ empirical developments takes for granted that neoliberalism, at its core, valorizes free markets. In contrast, the paper explores whether neoliberal intellectuals ever made such an argument. Using Friedrich Hayek and Milton Friedman as exemplars, our reading of canonical neoliberal texts focuses on author framing gestures, particular understandings of the term ‘science’, techniques of characterization, and constructions of epistemological legitimacy. This enables us to avoid the trap of assuming that these texts are about free markets and instead enquires into their constitution as literary artefacts. As such, we argue that the remaking of states and households rather than the promotion of free markets is at the core of neoliberalism. Our analysis has significant implications. For example, it means that authoritarian neoliberalism is not a departure from but actually more in line with the ‘pure’ neoliberal canon than in the past. Therefore, neoliberalism ought to be critiqued not for its rhetorical promotion of free markets but instead for seeking to reorganize societies in coercive, non-democratic and unequal ways. This also enables us to acknowledge that households are central to resistance to neoliberalism as well as to the neoliberal worldview itself

Bioderived dyes-mediated vat photopolymerization 3D printing of chitosan hydrogels for tissue engineering

The importance of 3D printable hydrogels is constantly increasing in the field of tissue engineering, due to their characteristic structure and similarity with the human body extracellular matrix (ECM). Herein, Quinizarin-based bioderived photoactive dyes were employed for the 3D printing of methacrylated chitosan by vat pho-topolymerization (VPP). Dyes are commonly needed in VPP to obtain good resolution avoiding the light scattering in the vat, here the bioderived molecules had further utility granting the printability with good resolution while acting both as photosensitizers and fillers/crosslinkers. Defined and detailed architectures in the range of millimetres were obtained with low printing times showing for the first time the possibility to obtain all-chitosan 3D structures with suspended features by Digital Light Processing (DLP), which is a form of vat photopolymerization; such a result is not achievable without the quinizarin-derived dyes. The same structures were achieved with an opti-mized concentration of poly(ethylene glycol) diacrylate, as a comparison, enhancing the resolution. For all the formulations, the important feature to obtain the gel printability (considering reactiveness, viscosity, shear thinning behaviour, mechanical properties and stability) were evaluated. The hydrogels mechanical character-ization and swelling properties were also tested and reported. Lastly, the possible application in tissue engi-neering was also evaluated through cell proliferation analysis over samples, including metabolic activity and DNA contempt assays. The use of such bioderived photoactive molecules that simultaneously act as photosensitizer enhancing the ink reactivity, as dye improving the definition of the final structures and as filler/crosslinker increasing the me-chanical stability, could represent a valuable route for the DLP printing of soft hydrogels