22 research outputs found
Three cases of advanced cutaneous squamous cell carcinoma treated with a combination of carboplatin and epirubicin
A CASE OF CHOLESTEROL EMBOLISM-INDUCED MULTIPLE STENOSIS OF THE SMALL INTESTINE TREATED WITH LAPAROSCOPY-ASSISTED RESECTION AFTER ENTEROSCOPIC TATTOOING
Successful Treatment of Necrotizing Fasciitis after Rectal Surgery with the Application of a Negative-pressure Wound Therapy: A Case Study
Machine Learning Prediction for Supplemental Oxygen Requirement in Patients with COVID-19
journal articl
Objective Assessment of Postoperative Gastrointestinal Motility in Elective Colonic Resection Using a Radiopaque Marker Provides an Evidence for the Abandonment of Preoperative Mechanical Bowel Preparation
Auxin induced carotenoid accumulation in GA and PDJ-treated citrus fruit after harvest
autho
A case of tamoxifen-induced hypertriglyceridemia monitoring the changes in lipoprotein fractions over time
Abstract Background Tamoxifen, which is one of the selective estrogen receptor modulators (SERMs), can bring out life-threatening complication, e.g. hypertriglyceridemia-induced acute pancreatitis, although it is rare. We precisely report changes in lipoprotein metabolism before and after tamoxifen discontinuation because there have been few reports of it. Case presentation 47-year-old premenopausal woman with dyslipidemia, type 2 diabetes, nonalcoholic fatty liver disease and chronic kidney disease was prescribed tamoxifen as adjuvant therapy after operation of breast cancer. She experienced severe tamoxifen-induced hypertriglyceridemia several months after dosing tamoxifen. Before cessation of tamoxifen, lipoprotein fraction test revealed marked stagnation of VLDL and IDL metabolisms, resulting in severe hypertriglyceridemia (serum triglyceride level was 1881 mg/dL). Seven days after tamoxifen withdrawal, lipoprotein fraction test showed that the metabolisms of endogenous lipoproteins were changed drastically. Conclusions From these results, we confirmed that tamoxifen certainly changes lipoprotein metabolism through suppression of post-heparin lipolytic activity. It is very important to evaluate the balance between benefit and risk before dosing tamoxifen and survey lipid profiles constantly during treatment to avoid life-threatening complication when prescription of tamoxifen is planned