Attitudes Toward Persons With Disabilities Among Japanese Social Work Students

The Modified Issues in Disability Scale (MIDS) was implemented on 194 social work students in Japan in order to assess their attitudes toward people with disabilities. Findings indicate that students do not hold strong prejudicial attitudes. Results also show gender differences and a lack of knowledge and experiences regarding disability issues among students

消費者の市販薬及び健康食品の購買行動に影響を及ぼす情報提供

学位の種別: 課程博士審査委員会委員 : （主査）東京大学准教授 小野 俊介, 東京大学特任准教授 堀 里子, 東京大学特任准教授 五十嵐 中, 東京大学講師 前田 和哉, 東京大学特任講師 桝田 祥子, 東京大学客員教授 木村 廣道, 帝京大学教授 関水 和久, 順天堂大学特任教授 入村 達郎University of Tokyo(東京大学

The Postsynaptic Density Proteins Homer and Shank Form a Polymeric Network Structure

The postsynaptic density (PSD) is crucial for synaptic functions, but the molecular architecture retaining its structure and components remains elusive. Homer and Shank are among the most abundant scaffolding proteins in the PSD, working synergistically for maturation of dendritic spines. Here, we demonstrate that Homer and Shank, together, form a mesh-like matrix structure. Crystallographic analysis of this region revealed a pair of parallel dimeric coiled coils intercalated in a tail-to-tail fashion to form a tetramer, giving rise to the unique configuration of a pair of N-terminal EVH1 domains at each end of the coiled coil. In neurons, the tetramerization is required for structural integrity of the dendritic spines and recruitment of proteins to synapses. We propose that the Homer-Shank complex serves as a structural framework and as an assembly platform for other PSD proteins.Massachusetts Institute of Technology. Biophysical Instrumentation FacilityRIKEN Brain Science InstituteNational Institutes of Health (U.S.) (Grant R01DA17310)Japan. Ministry of Education, Culture, Sports, Science and Technology (Grant-in-Aid for Scientific Research

Risk of higher dose methotrexate for renal impairment in patients with rheumatoid arthritis

Renal impairment is a major concern in patients taking high-dose methotrexate (MTX) for malignancy, but it has not been fully explored in rheumatoid arthritis (RA) patients taking low-dose MTX. This study aimed to elucidate the dose-dependent effects of MTX on the renal function of patients with RA. We retrospectively reviewed 502 consecutive RA patients who were prescribed MTX for >= 1 year at Okayama University Hospital between 2006 and 2018. The primary outcome was the change in estimated glomerular filtration rate (eGFR) over 1 year. The association between MTX dosage (= 12 mg/week) and the change in eGFR was evaluated using multiple linear regression analysis with adjustment for possible confounding factors including age, sex, disease duration, body weight, comorbidity, baseline eGFR, concomitant treatment, and disease activity. Mean patient age was 63 years; 394 (78%) were female. Median disease duration was 77 months, while mean MTX dosage was 8.6 mg/week. The last 1-year change of eGFR (mean +/- SD) in patients treated with MTX= 12 mg/week (n=97) decreased by 0.2 +/- 7.3, 0.6 +/- 8.6, and 4.5 +/- 7.9 mL/min/1.73 m(2)/year, respectively (p= 12 mg/week was still correlated with a decrease in 1-year eGFR (beta-coefficient:-2.5; 95% confidence interval,-4.3 to-0.6; p=0.0089) in contrast to MTX 8-12 mg/week. Careful monitoring of renal function is required in patients with MTX >= 12 mg/week over the course of RA treatment regardless of disease duration

UK agriculture and care visas: worker exploitation and obstacles to redress

This is a summary of research conducted by five academics (led by Primary Investigator Dr Inga Thiemann) in partnership with four non-governmental organisations (NGOs): Focus on Labour Exploitation (FLEX), Joint Council for the Welfare of Immigrants (JCWI), Southeast and East Asian Centre (SEEAC) and Kanlungan Filipino Consortium (Kanlungan), with support from UNISON. The project was funded through an open call for proposals by the Modern Slavery and Human Rights Policy and Evidence Centre (Modern Slavery PEC), which in turn is funded and supported by the UK Arts and Humanities Research Council (AHRC). The Modern Slavery PEC has actively supported the production of this Research Summary. However, the views expressed in this summary and the full report are those of the authors and not necessarily of the funders

Extracts of citrus Sudachi peel attenuate body weight gain in C57BL/6 mice fed a high-fat diet

Citrus Sudachi is the special local product of Tokushima Prefecture, and over 98% of Sudachi consumed in Japan every year is produced in Tokushima Prefecture. In this study, we evaluated the function of sudachi peel extract (SPE) using an animal model of obesity. C57BL/6 mice were fed a high-fat diet containing 1% SPE powder. Treatment with SPE significantly decreased body weight compared to that of mice fed a high-fat diet. A significant difference in body weight was observed between the control and SPE groups from 7 weeks after the start of the experiment, the significant difference continued until the end of the 14-week experiment. Reduction of blood glucose levels following insulin administration in SPE-treated mice was grater than that in control mice. Determination of mRNA expression in adipose tissue showed that the expression level of TNF-α in the SPE group was significantly decreased compared to that on the control group. These results suggest that SPE potentially has the ability to attenuate body weight gain