Prediction of far-field acoustic emissions from cavitation clouds during shock wave lithotripsy for development of a clinical device

This study presents the key simulation and decision stage of a multi-disciplinary project to develop a hospital device for monitoring the effectiveness of kidney stone fragmentation by shock wave lithotripsy (SWL). The device analyses, in real time, the pressure fields detected by sensors placed on the patient's torso, fields generated by the interaction of the incident shock wave, cavitation, kidney stone and soft tissue. Earlier free-Lagrange simulations of those interactions were restricted (by limited computational resources) to computational domains within a few centimetres of the stone. Later studies estimated the far-field pressures generated when those interactions involved only single bubbles. This study extends the free-Lagrange method to quantify the bubble–bubble interaction as a function of their separation. This, in turn, allowed identification of the validity of using a model of non-interacting bubbles to obtain estimations of the far-field pressures from 1000 bubbles distributed within the focus of the SWL field. Up to this point in the multi-disciplinary project, the design of the clinical device had been led by the simulations. This study records the decision point when the project's direction had to be led by far more costly clinical trials instead of the relatively inexpensive simulations. <br/

Visual Earth observation performance in the space environment. Human performance measurement 4: Flight experiments

A wide variety of secondary payloads have flown on the Space Transportation System (STS) since its first flight in the 1980's. These experiments have typically addressed specific issues unique to the zero-gravity environment. Additionally, the experiments use the experience and skills of the mission and payload specialist crew members to facilitate data collection and ensure successful completion. This paper presents the results of the Terra Scout experiment, which flew aboard STS-44 in November 1991. This unique Earth Observation experiment specifically required a career imagery analyst to operate the Spaceborne Direct-View Optical System (SpaDVOS), a folded optical path telescope system designed to mount inside the shuttle on the overhead aft flight deck windows. Binoculars and a small telescope were used as backup optics. Using his imagery background, coupled with extensive target and equipment training, the payload specialist was tasked with documenting the following: (1) the utility of the equipment; (2) his ability to acquire and track ground targets; (3) the level of detail he could discern; (4) the atmospheric conditions; and (5) other in-situ elements which contributed to or detracted from his ability to analyze targets. Special emphasis was placed on the utility of a manned platform for research and development of future spaceborne sensors. The results and lessons learned from Terra Scout will be addressed including human performance and equipment design issues

Testing the Meson Cloud Model in Inclusive Meson Production

We have applied the Meson Cloud Model to calculate inclusive momentum spectra of pions and kaons produced in high energy proton-proton and proton-nucleus collisions. For the first time these data are used to constrain the cloud cut-off parameters. We show that it is possible to obtain a reasonable description of data, especially the large $x_F$ ($x_F \geq 0.2$) part of the spectrum and at the same time describe (partially) the E866 data on $\bar d - \bar u$ and $\bar d / \bar u$. We also discuss the relative strength of the $\pi N$ and $\pi \Delta$ vertices. We find out that the corresponding cut-off parameters should be both soft and should not differ by more than 200 MeV from each other. An additional source (other than the meson cloud) of sea antiquark asymmetry, seems to be necessary to completely explain the data. A first extension of the MCM to proton nucleus collisions is discussed.Comment: 14 pages, Latex, 6 ps figures. Submitted to Phys. Rev.

Folding of a donor–acceptor polyrotaxane by using noncovalent bonding interactions

Mechanically interlocked compounds, such as bistable catenanes and bistable rotaxanes, have been used to bring about actuation in nanoelectromechanical systems (NEMS) and molecular electronic devices (MEDs). The elaboration of the structural features of such rotaxanes into macromolecular materials might allow the utilization of molecular motion to impact their bulk properties. We report here the synthesis and characterization of polymers that contain π electron-donating 1,5-dioxynaphthalene (DNP) units encircled by cyclobis(paraquat-p-phenylene) (CBPQT4+), a π electron-accepting tetracationic cyclophane, synthesized by using the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC). The polyrotaxanes adopt a well defined “folded” secondary structure by virtue of the judicious design of two DNP-containing monomers with different binding affinities for CBPQT4+. This efficient approach to the preparation of polyrotaxanes, taken alongside the initial investigations of their chemical properties, sets the stage for the preparation of a previously undescribed class of macromolecular architectures

Resolving X-Ray Photoelectron Spectra of Ionic Liquids with Difference Spectroscopy

X-ray photoelectron spectroscopy (XPS) is a powerful element-specific technique to determine the composition and chemical state of all elements in an involatile sample. However, for elements such as carbon, the wide variety of chemical states produce complex spectra that are difficult to interpret, consequently concealing important information due to the uncertainty in signal identity. Here we report a process whereby chemical modification of carbon structures with electron withdrawing groups can reveal this information, providing accurate, highly refined fitting models far more complex than previously possible. This method is demonstrated with functionalised ionic liquids bearing chlorine or trifluoromethane groups that shift electron density from targeted locations. By comparing the C 1s spectra of non-functional ionic liquids to their functional analogues, a series of difference spectra can be produced to identify exact binding energies of carbon photoemissions, which can be used to improve the C 1s peak fitting of both samples. Importantly, ionic liquids possess ideal chemical and physical properties, which enhance this methodology to enable significant progress in XPS peak fitting and data interpretation

High-density information storage in an absolutely defined aperiodic sequence of monodisperse copolyester

Synthesis of a polymer composed of a large discrete number of chemically distinct monomers in an absolutely defined aperiodic sequence remains a challenge in polymer chemistry. The synthesis has largely been limited to oligomers having a limited number of repeating units due to the difficulties associated with the step-by-step addition of individual monomers to achieve high molecular weights. Here we report the copolymers of ??-hydroxy acids, poly(phenyllactic-co-lactic acid) (PcL) built via the cross-convergent method from four dyads of monomers as constituent units. Our proposed method allows scalable synthesis of sequence-defined PcL in a minimal number of coupling steps from reagents in stoichiometric amounts. Digital information can be stored in an aperiodic sequence of PcL, which can be fully retrieved as binary code by mass spectrometry sequencing. The information storage density (bit/Da) of PcL is 50% higher than DNA, and the storage capacity of PcL can also be increased by adjusting the molecular weight (~38???kDa)

Compressible bubble dynamic simulations with central-upwind schemes

This paper discusses the implementation of an explicit density-based solver, based on the central-upwind schemes originally suggested by Kurganov, for the simulation of cavitating bubble dynamic flows. Explicit density based solvers are suited for highly dynamic, violent flows, involving large density ratios, as is rather common in cavitating flows. Moreover, the central-upwind schemes have the advantage of avoiding direct evaluation of the Jacobian matrix or estimation of the wave pattern emerging from Euler equations. Second order accuracy can be achieved with TVD MUSCL schemes. Basic comparison with the predicted wave pattern of the central-upwind schemes is performed with the exact solution of the Riemann problem showing an excellent agreement. Then several different bubble configurations were tested, similar to the work of Lauer et al. (2012). The central-upwind schemes prove to be able to handle the large pressure and density ratios appearing in cavitating flows, giving similar predictions in the evolution of the bubble shape

Flavor and Charge Symmetry in the Parton Distributions of the Nucleon

Recent calculations of charge symmetry violation(CSV) in the valence quark distributions of the nucleon have revealed that the dominant symmetry breaking contribution comes from the mass associated with the spectator quark system.Assuming that the change in the spectator mass can be treated perturbatively, we derive a model independent expression for the shift in the parton distributions of the nucleon. This result is used to derive a relation between the charge and flavor asymmetric contributions to the valence quark distributions in the proton, and to calculate CSV contributions to the nucleon sea. The CSV contribution to the Gottfried sum rule is also estimated, and found to be small