The mechanism of realization of antiseizure effects of cerebellar electrical stimulation

We have reported that electrical stimulations of cerebellar structures resulted in the heightened antiseizure effectiveness of diazepam against pentylenetetrazol (PTZ)-kindled seizures. Such effects might be explained by the increased antioxidant mechanisms in the brain tissue, which counterparts oxidative stress, as a fundamental pathogenetic mechanism of chronic epileptic activity. The work aimed to investigate the state of antioxidant defense in the cerebral cortex of PTZ-kindled rats under electrical stimulations (100 Hz, 0,25 ms, 50-100 mcA, 2,5 s) of the paleocerebellar cortex (V-VII lobules)

Pentylenetetrazole-induced kindling as a model metabolic syndrome

Data on the relationship between epilepsy and metabolic syndrome justified the evaluation of MS markers expression in PTZ-kindled rats. PTZ kindling was induced in four months aged male Wistar rats with three weeks epileptogen (35.0 mg/kg, i.p.) administration. Those animals with fully developed generalized seizures were used for investigations. The glucose tolerance test (GTT) was followed by a significant rising in blood glucose level 30 min after glucose i.p. administration (2.0 g/kg) up to 395.7+47.2 mg/dl), which exceeded the control data by 1.74 times (P<0.001). Insulin tolerance test (0.75 U of insulin/kg) revealed in 15 min after glucose i.p. administration (2.0 g/kg) up to 114.3+15.7 mg/dl), which exceed the control data by 31.3% (P<0.001)