215 research outputs found
Cytochrome oxidase subunit VI of Trypanosoma brucei is imported without a cleaved presequence and is developmentally regulated at both RNA and protein levels
Mitochondrial respiration in the African trypanosome undergoes dramatic developmental stage regulation. This requires co-ordinated control of components encoded by both the nuclear genome and the kinetoplast, the unusual mitochondrial genome of these parasites. As a model for understanding the co-ordination of these genomes, we have examined the regulation and mitochondrial import of a nuclear-encoded component of the cytochrome oxidase complex, cytochrome oxidase subunit VI (COXVI). By generating transgenic trypanosomes expressing intact or mutant forms of this protein, we demonstrate that COXVI is not imported using a conventional cleaved presequence and show that sequences at the N-terminus of the protein are necessary for correct mitochondrial sorting. Analyses of endogenous and transgenic COXVI mRNA and protein expression in parasites undergoing developmental stage differentiation demonstrates a temporal order of control involving regulation in the abundance of, first, mRNA and then protein. This represents the first dissection of the regulation and import of a nuclear-encoded protein into the cytochrome oxidase complex in these organisms, which were among the earliest eukaryotes to possess a mitochondrion
GEMS: The Size Evolution of Disk Galaxies
We combine HST imaging from the GEMS survey with photometric redshifts from
COMBO-17 to explore the evolution of disk-dominated galaxies since z<1.1. The
sample is comprised of all GEMS galaxies with Sersic indices n<2.5, derived
from fits to the galaxy images. We account fully for selection effects through
careful analysis of image simulations; we are limited by the depth of the
redshift and HST data to the study of galaxies with absolute magnitudes
M(V)10. We find strong evolution in
the magnitude-size scaling relation for galaxies with M(V)<-20, corresponding
to a brightening of 1 mag per sqarcsec in rest-frame V-band by z=1. Yet, disks
at a given absolute magnitude are bluer and have lower stellar mass-to-light
ratios at z=1 than at the present day. As a result, our findings indicate weak
or no evolution in the relation between stellar mass and effective disk size
for galaxies with log(M)>10 over the same time interval. This is strongly
inconsistent with the most naive theoretical expectation, in which disk size
scales in proportion to the halo virial radius, which would predict that disks
are a factor of two denser at fixed mass at z=1. The lack of evolution in the
stellar mass-size relation is consistent with an ``inside-out'' growth of
galaxy disks on average (galaxies increasing in size as they grow more
massive), although we cannot rule out more complex evolutionary scenarios.Comment: 22 pages, 16 figures, submitted to Ap
An Explanation for the Observed Weak Size Evolution of Disk Galaxies
Surveys of distant galaxies with the Hubble Space Telescope and from the
ground have shown that there is only mild evolution in the relationship between
radial size and stellar mass for galactic disks from z~1 to the present day.
Using a sample of nearby disk-dominated galaxies from the Sloan Digital Sky
Survey (SDSS), and high redshift data from the GEMS (Galaxy Evolution from
Morphology and SEDs) survey, we investigate whether this result is consistent
with theoretical expectations within the hierarchical paradigm of structure
formation. The relationship between virial radius and mass for dark matter
halos in the LCDM model evolves by about a factor of two over this interval.
However, N-body simulations have shown that halos of a given mass have less
centrally concentrated mass profiles at high redshift. When we compute the
expected disk size-stellar mass distribution, accounting for this evolution in
the internal structure of dark matter halos and the adiabatic contraction of
the dark matter by the self-gravity of the collapsing baryons, we find that the
predicted evolution in the mean size at fixed stellar mass since z~1 is about
15-20 percent, in good agreement with the observational constraints from GEMS.
At redshift z~2, the model predicts that disks at fixed stellar mass were on
average only 60% as large as they are today. Similarly, we predict that the
rotation velocity at a given stellar mass (essentially the zero-point of the
Tully-Fisher relation) is only about 10 percent larger at z~1 (20 percent at
z~2) than at the present day.Comment: 13 pages, 6 figures, accepted for publication in ApJ. Revised in
response to referee's comments to improve clariry. Results are unchange
A Study of the 't Hooft Model with the Overlap Dirac Operator
We present the results of an exploratory numerical study of two dimensional
QCD with overlap fermions. We have performed extensive simulations for U(N_c)
and SU(N_c) color groups with N_c=2, 3, 4 and coupling constants chosen to
satisfy the 't Hooft condition g^2 N_c =const=4/3. We have computed the meson
spectrum and decay constants, the topological susceptibility and the chiral
condensate. For U(N_c) gauge groups, our results indicate that the
Witten-Veneziano relation is satisfied within our statistical errors and that
the chiral condensate for N_f=1 is compatible with a non-zero value. Our
results exhibit universality in N_c and confirm once more the excellent chiral
properties of the overlap-Dirac operator.Comment: 18 pages, 4 figure
Co-ordination between Rashba spin-orbital interaction and space charge effect and enhanced spin injection into semiconductors
We consider the effect of the Rashba spin-orbital interaction and space
charge in a ferromagnet-insulator/semiconductor/insulator-ferromagnet junction
where the spin current is severely affected by the doping, band structure and
charge screening in the semiconductor. In diffusion region, if the the
resistance of the tunneling barriers is comparable to the semiconductor
resistance, the magnetoresistance of this junction can be greatly enhanced
under appropriate doping by the co-ordination between the Rashba effect and
screened Coulomb interaction in the nonequilibrium transport processes within
Hartree approximation.Comment: 4 pages, 3 figure
The Evolution of Early-type Red Galaxies with the GEMS Survey: Luminosity-size and Stellar Mass-size Relations Since z=1
We combine HST/ACS imaging from the GEMS survey with redshifts and rest-frame
quantities from COMBO-17 to study the evolution of morphologically early-type
galaxies with red colors since z=1. We use a new large sample of 728 galaxies
with centrally-concentrated radial profiles (Sersic n>2.5) and rest-frame U-V
colors on the red sequence. By appropriate comparison with the local relations
from SDSS, we find that the luminosity-size (L-R) and stellar mass-size (M-R)
relations evolve in a manner that is consistent with the passive aging of
ancient stars. By itself, this result is consistent with a completely passive
evolution of the red early-type galaxy population. If instead, as demonstrated
by a number of recent surveys, the early-type galaxy population builds up in
mass by a factor of 2 since z=1, our results imply that new additions to the
early-type galaxy population follow similar L-R and M-R correlations, compared
to the older subset of early-type galaxies. Adding early-type galaxies to the
red sequence through disk fading appears to be consistent with the data.
Through comparison with models, the role of dissipationless merging is limited
to <1 major merger on average since z=1 for the most massive galaxies.
Predictions from models of gas-rich mergers are not yet mature enough to allow
a detailed comparison to our observations. We find tentative evidence that the
amount of luminosity evolution depends on galaxy stellar mass, such that the
least massive galaxies show stronger luminosity evolution compared to more
massive early types. This could reflect a different origin of low-mass
early-type galaxies and/or younger stellar populations; the present data is
insufficient to discriminate between these possibilities. (abridged)Comment: Submitted to ApJ, 23 pages, Latex using emulateapj5.sty and
onecolfloat.sty (included), 10 figures, version with full resolution figures
at http://www.astro.umass.edu/~dmac/Papers/ETevol.hires.p
Properties of Graphene: A Theoretical Perspective
In this review, we provide an in-depth description of the physics of
monolayer and bilayer graphene from a theorist's perspective. We discuss the
physical properties of graphene in an external magnetic field, reflecting the
chiral nature of the quasiparticles near the Dirac point with a Landau level at
zero energy. We address the unique integer quantum Hall effects, the role of
electron correlations, and the recent observation of the fractional quantum
Hall effect in the monolayer graphene. The quantum Hall effect in bilayer
graphene is fundamentally different from that of a monolayer, reflecting the
unique band structure of this system. The theory of transport in the absence of
an external magnetic field is discussed in detail, along with the role of
disorder studied in various theoretical models. We highlight the differences
and similarities between monolayer and bilayer graphene, and focus on
thermodynamic properties such as the compressibility, the plasmon spectra, the
weak localization correction, quantum Hall effect, and optical properties.
Confinement of electrons in graphene is nontrivial due to Klein tunneling. We
review various theoretical and experimental studies of quantum confined
structures made from graphene. The band structure of graphene nanoribbons and
the role of the sublattice symmetry, edge geometry and the size of the
nanoribbon on the electronic and magnetic properties are very active areas of
research, and a detailed review of these topics is presented. Also, the effects
of substrate interactions, adsorbed atoms, lattice defects and doping on the
band structure of finite-sized graphene systems are discussed. We also include
a brief description of graphane -- gapped material obtained from graphene by
attaching hydrogen atoms to each carbon atom in the lattice.Comment: 189 pages. submitted in Advances in Physic
Prevalence of Abnormalities in Vestibular Function and Balance among HIV-Seropositive and HIV-Seronegative Women and Men
BACKGROUND: Most HIV-seropositive subjects in western countries receive highly active antiretroviral therapy (HAART). Although many aspects of their health have been studied, little is known about their vestibular and balance function. The goals of this study were to determine the prevalences of vestibular and balance impairments among HIV-seropositive and comparable seronegative men and women and to determine if those groups differed. METHODS: Standard screening tests of vestibular and balance function, including head thrusts, Dix-Hallpike maneuvers, and Romberg balance tests on compliant foam were performed during semiannual study visits of participants who were enrolled in the Baltimore and Washington, D. C. sites of the Multicenter AIDS Cohort Study and the Women's Interagency HIV Study. RESULTS: No significant differences by HIV status were found on most tests, but HIV-seropositive subjects who were using HAART had a lower frequency of abnormal Dix-Hallpike nystagmus than HIV-seronegative subjects. A significant number of nonclassical Dix-Hallpike responses were found. Age was associated with Romberg scores on foam with eyes closed. Sex was not associated with any of the test scores. CONCLUSION: These findings suggest that HAART-treated HIV infection has no harmful association with vestibular function in community-dwelling, ambulatory men and women. The association with age was expected, but the lack of association with sex was unexpected. The presence of nonclassical Dix-Hallpike responses might be consistent with central nervous system lesions
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