Efficacy and safety of vandetanib in progressive and symptomatic medullary thyroid Cancer: Post hoc analysis from the ZETA trial

PURPOSE We conducted a post hoc analysis of the vandetanib phase III trial involving patients with advanced medullary thyroid cancer (MTC) to assess the efficacy and safety of vandetanib in patients with progressive and symptomatic MTC. The primary objective of the analysis was to determine progression-free survival (PFS) of these patients. PATIENTS AND METHODS Eligible patients from the ZETA trial were divided into 4 disease severity subgroups: progression and symptoms, symptoms only, progression only, and no progression and no symptoms assessed at baseline. PFS, determined from objective tumor measurements performed by the local investigator, overall survival (OS), time to worsening of pain (TWP), and objective response rate (ORR) were evaluated. RESULTS Of the 331 patients in this trial, 184 had symptomatic and progressive disease at baseline. In this subgroup, results were similar in magnitude to those observed in the overall trial for PFS (hazard ratio [HR], 0.43; 95% CI, 0.28 to 0.64; P, .0001), OS (HR, 1.08; 95% CI, 0.72 to 1.61; P 5 .71), and TWP (HR, 0.67; 95% CI, 0.43 to 1.04; P 5 .07), and the observed adverse events were consistent with the known safety profile of vandetanib. In this subgroup, the ORR was 37% in the treatment arm versus 2% in the placebo arm. CONCLUSION Vandetanib demonstrated clinical benefit—specifically, increased PFS—in patients with symptomatic and progressive MTC

Nonlinear lattice model of viscoelastic Mode III fracture

We study the effect of general nonlinear force laws in viscoelastic lattice models of fracture, focusing on the existence and stability of steady-state Mode III cracks. We show that the hysteretic behavior at small driving is very sensitive to the smoothness of the force law. At large driving, we find a Hopf bifurcation to a straight crack whose velocity is periodic in time. The frequency of the unstable bifurcating mode depends on the smoothness of the potential, but is very close to an exact period-doubling instability. Slightly above the onset of the instability, the system settles into a exactly period-doubled state, presumably connected to the aforementioned bifurcation structure. We explicitly solve for this new state and map out its velocity-driving relation

Выбор оптимального метода повышения нефтеотдачи на Новопортовском нефтегазоконденсатном месторождении (ЯНАО)

В работе проведен анализ современных методов увеличения нефтеотдачи. Выполнен анализ применяемых мероприятий, направленных на увеличения нефтеотдачи в рамках Новопортовского месторождения. Предложена технология увеличения нефтеотдачи, показана положительная эффективность применения технологии смешивающихся вытеснений.The analysis of modern methods of enhanced oil recovery is carried out. The analysis of the measures applied to increase oil recovery within the Novoportovskoye field has been carried out. The technology of enhanced oil recovery is proposed, the positive efficiency of the application of the technology of miscible displacement is shown

Energy radiation of moving cracks

The energy radiated by moving cracks in a discrete background is analyzed. The energy flow through a given surface is expressed in terms of a generalized Poynting vector. The velocity of the crack is determined by the radiation by the crack tip. The radiation becomes more isotropic as the crack velocity approaches the instability threshold.Comment: 7 pages, embedded figure

Development of a three-phase mathematical model of the catalytic cracking feedstock hydrotreating

Integration of mathematical models to the oil refining industry allows predicting the product composition and properties, as well as optimizing the process technological parameters without significant material and time costs. This paper describes an improved mathematical model of the vacuum distillate hydrotreating, taking into account presence of three phases in the system

Разработка технологии изготовления детали «Втулка подшипника»

Цели и задачи исследования: создание эффективного маршрута технологического процесса изготовления детали "Втулка подшипника". В работе изложено обоснование выполнение ВКР, выполнен анализ чертежа детали и её технологичности, определен тип производства, описан принцип выбора заготовки в соответствие с её материалом и серийностью производства, выполнен чертёж заготовки, разработан маршрут обработки детали с представлением операционных эскизов и описанием переходов по каждой операции, рассчитаны припуски на обработку и технологические размеры, выполнен размерный анализ техпроцесса с уточнением технологических размеров, рассчитаны режимы резания и требуемая мощность оборудования для каждой операции, назначена модель станка, рассчитано время выполнения каждой операции.The paper presents the rationale for the implementation of Diploma Thesis, the analysis of the drawing of the part and its technology, the type of production, the principle of selection of procurement in accordance with its material and serial production, carried out a drawing of the initial workpiece, the route processing of detail with operational sketches and descriptions of transitions for each operation, calculated allowances for processing and technological dimensions, is made dimensional analysis of the process with the specification of the technological dimensions, the cutting modes for each technological transition and the required power of the equipment for each operation are calculated, the machine model is assigned, and the execution time for each operation is calculated

Автоматизация построения геолого-технического наряда на строительство скважин

Tunnel junctions of Co(10 nm)/AlOx (nominally 2 nm)/Co(20 nm) have been prepared by molecular beam epitaxy applying a shadow mask technique in conjunction with an UV light-assisted oxidation process of the AlOx barrier. The quality of the AlOx barrier has been proven by x-ray photoelectron spectroscopy and temperature dependent tunneling magnetoresistance (TMR) measurements. Optimum-oxidized tunnel junctions show a TMR of 20% at 285 K and up to 36% at 100 K. At 285 K the TMR values as a function of oxidation time are not symmetric about the optimum time. For underoxidized junctions the TMR is reduced more strongly than for overoxidized junctions. The temperature dependence of the junction s resistance is a clear and reliable indicator whether pinholes (or imperfections)contribute to the conduction across the barrier